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Gastroenterology
Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Yeo Rae Moon, Yun Jeong Lim
Korean J Intern Med. 2024;39(2):261-271. Published online December 14, 2023
Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper ..
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Association between eupatilin and reduction in small bowel bleeding in aspirin users and aspirin plus acid suppressant users
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Hyun Jung Ahn, Yun Jeong Lim
Korean J Intern Med. 2023;38(4):484-492. Published online May 19, 2023
Background/Aims: Capsule endoscopy (CE) has shown that low-dose aspirin occasionally causes small bowel (SB) bleeding. We herein evaluated the protective effects of mucoprotective agents (MPAs) on SB bleeding in aspirin users using the nationwide database of claims data from the National Health Insu..
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Nephrology
Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients
AJin Cho, Myung Jin Choi, Young-Ki Lee, Han Chae Hoon, Ja-Ryong Koo, Jong-Woo Yoon, Jung-Woo Noh
Korean J Intern Med. 2019;34(6):1304-1312. Published online July 23, 2018
Background/Aims: Maintaining the patency of vascular access (VA) in hemodialysis (HD) patients is important and can be life-saving. We investigated the effects of aspirin resistance and mean platelet volume (MPV) on VA failure in HD patients.
Methods: We enrolled 163 patients on maintenance HD. VA ..
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Gastroenterology
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis
Ki-Nam Shim, Jin Il Kim, Nayoung Kim, Sang Gyun Kim, Yun Ju Jo, Su Jin Hong, Jeong Eun Shin, Gwang Ha Kim, Kyung Sik Park, Suck Chei Choi, Joong Goo Kwon, Jie-Hyun Kim, Hyun Jin Kim, Ji Won Kim
Korean J Intern Med. 2019;34(5):1008-1021. Published online June 1, 2018
Background/Aims: Irsogladine maleate, an enhancer of gastric mucosal protective factors, has demonstrated its efficacy for various gastric mucosal injuries. The aim of this study was to evaluate the efficacy and safety of irsogladine for prevention of nonsteroidal anti-inflammatory drugs (NSAIDs) or..
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Cardiology
Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Korean J Intern Med. 2018;33(3):522-531. Published online October 19, 2017
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated.
Methods: Blood sam..
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Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation
Yun-Kyeong Cho, Chang-Wook Nam, Hyoung-Seob Park, Hyuck-Jun Yoon, Hyungseop Kim, Seung-Ho Hur, Yoon-Nyun Kim, Jang-Hoon Lee, Dong-Heon Yang, Bong-Ryeol Lee, Byung-Chun Jung, Woong Kim, Jong-Seon Park, Jin-Bae Lee, Kee-Sik Kim, Kwon-Bae Kim
Korean J Intern Med. 2014;29(2):210-216. Published online February 27, 2014
Background/Aims: Combination single-pill therapy can improve cost-effectiveness in a typical medical therapy. However, there is a little evidence about the efficacy and tolerability of combination single-pill antiplatelet therapy after percutaneous coronary intervention (PCI) with drug-eluting stent..
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Airway Responsiveness to Inhaled Aspirin is Influenced by Airway Hyperresponsiveness in Asthmatic Patients
Sungsoo Kim, Inseon S. Choi, Yeon-Joo Kim, Chang-Seong Kim, Eui-Ryoung Han, Dong-Jin Park, Dae-Eun Kim
Korean J Intern Med. 2010;25(3):309-316. Published online August 31, 2010
Background/AimsMany patients with aspirin-induced asthma have severe methacholine airway hyperresponsiveness (AHR), suggesting a relationship between aspirin and methacholine in airway response. This study was performed to determine whether methacholine AHR affects the respons..
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Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma
Jung-Mi Oh, Seung-Hyun Kim, Chang-Hee Suh, Dong-Ho Nahm, Hae-Sim Park, Young-Mok Lee, June-Hyuk Lee, Choon-Sik Park, Hyung-Doo Shin
Korean J Intern Med. 2005;20(3):232-236. Published online September 30, 2005
BackgroundGlutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be asso..
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