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New targets for type 2-low asthma
Quang Luu Quoc, Youngwoo Choi, Gyu-Young Hur, Hae-Sim Park
Korean J Intern Med. 2024;39(2):215-227. Published online February 6, 2024
Asthma is characterized by airway obstruction and inflammation, and presents significant diagnostic and treatment challenges. The concept of endotypes has improved understanding of the mechanisms of asthma and has stimulated the development of effective treatment strategies. Sputum profiles may be u..
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Pulmonology
Short-acting β2-agonist prescriptions in patients with asthma: findings from the South Korean cohort of SABINA III
Kwang-Ha Yoo, Sang-Ha Kim, Sang-Heon Kim, Ji-Yong Moon, Heung-Woo Park, Yoon-Seok Chang, Maarten J.H.I Beekman
Korean J Intern Med. 2024;39(1):123-136. Published online December 7, 2023
Background/Aims: Despite short-acting β2-agonist (SABA) overuse being associated with poor asthma outcomes, data on SABA use in South Korea is scarce. Herein, we describe prescription patterns of SABA and other asthma medications in patients from the South Korean cohort of the SABA use IN Asthma (SAB..
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Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases
Junghyun Kim, Soo Jie Chung, Woo Jin Kim
Korean J Intern Med. 2024;39(1):25-33. Published online January 1, 2024
A high level of particulate matter (PM) in air is correlated with the onset and development of chronic respiratory diseases. We conducted a systematic literature review, searching the MEDLINE, EMBASE, and Cochrane databases for studies of biomarkers of the effect of PM exposure on chronic respirator..
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Pulmonology
Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
Heemoon Park, Jaeyoung Cho, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sun Mi Choi
Korean J Intern Med. 2022;37(2):387-397. Published online December 7, 2021
Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evalu..
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The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma
Sang-Heon Kim, Hyun Lee, So-Young Park, So Young Park, Woo-Jung Song, Joo-Hee Kim, Heung-Woo Park, You Sook Cho, Ho Joo Yoon; on behalf of the KoSAR investigators
Korean J Intern Med. 2022;37(2):249-260. Published online February 28, 2022
Severe asthma constitutes a serious health burden with significant morbidity and socioeconomic costs. The development and introduction of new biologics targeting type 2 inflammation changed the paradigm for management of severe asthma and initiated a biological era. These changes impose a challenge ..
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Pulmonology
Patterns of medical care utilization according to environmental factors in asthma and chronic obstructive pulmonary disease patients
Eun-Jung Jo, Min-Hyeok Choi, Chang-Hoon Kim, Kyung-Mi Won, Yoo-Keun Kim, Ju-Hee Jeong, Hye Yeon An, Mi-Kyoung Hwang, Hye-Kyung Park
Korean J Intern Med. 2021;36(5):1146-1156. Published online February 10, 2021
Background/Aims: Weather and air pollution are associated with the exacerbation of respiratory diseases. We investigated patterns of medical care use according to meteorological factors and air pollution in patients with asthma or chronic obstructive pulmonary disease (COPD).
Methods: We analyzed t..
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Allergy
Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma
[corrected-article]
Jae-Woo Jung, Hae-Sim Park, Choon-Sik Park, Sang-Heon Cho, Inseon S. Choi, Hee-Bom Moon, Soon Seog Kwon, Ho Joo Yoon, Jung Won Park, Jong-Myung Lee, Dong-Chull Choi, Byoung Whui Choi
Korean J Intern Med. 2021;36(4):1001-1013. Published online June 1, 2021
Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma.
Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement in the quality of life with the additional administration of omalizumab for 24 w..
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MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway
Jung Hur, Chin Kook Rhee, Sook Young Lee, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2021;36(3):706-720. Published online February 18, 2021
Background/Aims: Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling are not completely understood. We investigated the effects of in..
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Pulmonology
Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies
Mi-Kyeong Kim, Hae-Sim Park, Choon-Sik Park, Soung-Jun Min, Frank C. Albers, Steven W. Yancey, Bhabita Mayer, Namhee Kwon
Korean J Intern Med. 2021;36(2):362-370. Published online May 26, 2020
Background/Aims: The efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in a global clinical trial programme. This post hoc analysis assesses the efficacy and safety of mepolizumab in Korean patients.
Methods: Data from Korean patients in the Ph..
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Allergy
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression
Pureun-Haneul Lee, Jisu Hong, An-Soo Jang
Korean J Intern Med. 2020;35(5):1229-1237. Published online February 28, 2020
Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism for tight junctional protein claudin (CLDN) 18 is regulate..
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Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics
Gyu-Young Hur, Young-Min Ye, Eunmi Yang, Hae-Sim Park
Korean J Intern Med. 2020;35(4):988-997. Published online November 15, 2019
Background/Aims: Asthma is not a single disease but, rather, a heterogeneous inf lammatory disorder with various pathogenic mechanisms. We analyzed the associations between the cellular profile of sputum and the serum levels of inflammatory mediators/cytokines in a cohort of adult asthmatics.
Metho..
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Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Pulmonology
Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2020;35(3):619-629. Published online March 19, 2020
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the exp..
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Allergy
Association between primary immunodeficiency and asthma exacerbation in adult asthmatics
So-Hee Lee, Ga-Young Ban, Su-Chin Kim, Chang-Gyu Chung, Hyun-Young Lee, Ji-Ho Lee, Hae-Sim Park
Korean J Intern Med. 2020;35(2):449-456. Published online June 14, 2019
Background/Aims: Primary immunodef iciency (PID) is a serious comorbid condition in adult asthmatics that have frequent exacerbations, which requires monthly replacement of intravenous immunoglobulin (IVIG). However, the prevalence and clinical significance of PID in adult asthmatics in Korea have n..
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Chronic cough, not asthma, is associated with depression in the elderly: a community-based population analysis in South Korea
Kyoung-Hee Sohn, Woo-Jung Song, Sae-Hoon Kim, Hak-Chul Jang, Ki Woong Kim, Yoon-Seok Chang
Korean J Intern Med. 2019;34(6):1363-1371. Published online October 16, 2019
Background/Aims: Depression and allergic diseases, including asthma, are frequently reported as comorbid conditions. However, their associations have been rarely examined in community-based elderly populations.
Methods: The analyses were performed using the baseline data set of the Korean Longitudi..
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Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2018;33(6):1210-1223. Published online April 19, 2018
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in o..
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Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Korean J Intern Med. 2018;33(4):807-814. Published online January 17, 2018
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsi..
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The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Korean J Intern Med. 2018;33(3):604-611. Published online July 21, 2017
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We e..
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Pulmonology
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Allergy
Relationship between serum IgA level and allergy/asthma
Woo-Jin Kim, Inseon S. Choi, Chang Seong Kim, Jeong-Hyeon Lee, Hyeon-Wook Kang
Korean J Intern Med. 2017;32(1):137-145. Published online September 2, 2016
Background/Aims: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR). Methods: The clinical records of 1,136 adul..
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