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Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection
Jeong-Hoon Lim, Byung Ha Chung, Sang-Ho Lee, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
Korean J Intern Med. 2022;37(3):520-533. Published online April 15, 2022
Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft rejection. However, it is invasive and reactive, and continuous monitoring is unreal..
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Nephrology
Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients
Hyunjoo Bae, Do Hyun Na, Ji-Yeun Chang, Ki Hyun Park, Ji Won Min, Eun Jeong Ko, Hyeyoung Lee, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
Korean J Intern Med. 2021;36(1):164-174. Published online April 3, 2020
Background/Aims: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods: We included 68 KTRs with different viremia status (no virem..
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Characteristics of kidney transplantation recipients over time in South Korea
Sehoon Park, Myoungsuk Kim, Ji Eun Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2020;35(6):1457-1467. Published online March 30, 2020
Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 t..
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Infectious diseases
Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant
Taeeun Kim, Hyun-Jeong Lee, Sun-Mi Kim, Joo Hee Jung, Sung Shin, Young-Hoon Kim, Heungsup Sung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Duck Jong Han
Korean J Intern Med. 2020;35(2):438-448. Published online June 7, 2018
Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections.
Methods: All adult recipients admitted for living-donor KT between March 20..
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Nephrology
Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy
Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2019;34(2):375-382. Published online December 15, 2017
Background/Aims: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV infection after ATG administration as anti-rejection therapy.
Methods..
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Clinical significance of Th17 cells in kidney transplantation
Byung Ha Chung, Chul Woo Yang, Mi-La Cho
Korean J Intern Med. 2018;33(5):860-866. Published online May 31, 2018
Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and..
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Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
Korean J Intern Med. 2018;33(2):356-366. Published online August 21, 2017
Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes ..
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Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody
in kidney transplant recipients with allograft dysfunction
Byung Ha Chung, Jeong Ho Kim, Bum Soon Choi, Cheol Whee Park, Ji-Il Kim, In Sung Moon, Yong-Soo Kim, Yeong Jin Choi, Eun-Jee Oh, Chul Woo Yang
Korean J Intern Med. 2018;33(1):157-167. Published online October 20, 2016
Background/Aims: This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction.
Methods: We analyzed the presence of HLA-DSA in 210 KTRs ..
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Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient
Young Jae Park, Hyun Jin Bae, Ji-Yeun Chang, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2017;32(4):750-752. Published online February 4, 2016
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Nephrology
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
Korean J Intern Med. 2017;32(3):505-513. Published online March 25, 2016
Background/Aims: There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vi..
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Infectious diseases
Differences of cytomegalovirus diseases between kidney and hematopoietic stem cell transplant recipients during preemptive therapy
Tark Kim, Yu-Mi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Heungsup Sung, Joo Hee Jung, Sung Shin, Young Hoon Kim, Young-Ah Kang, Young-Shin Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Su-Kil Park, Duck Jong Han, Sung-Han Kim
Korean J Intern Med. 2016;31(5):961-970. Published online April 8, 2016
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and..
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Nephrology
Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors
Ji Hyun Yu, Kyoung Woon Kim, Bo-Mi Kim, Byung Ha Chung, Mi-La Cho, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
Korean J Intern Med. 2016;31(3):552-559. Published online March 11, 2016
Background/Aims: Sirolimus (SRL) is a promising immunosuppressant replacingcalcineurin inhibitors (CNIs). This study was performed to evaluate the safetyand immunologic benefits of conversion to SRL in stable kidney transplant (KT)recipients exposed to CNIs for long periods.
Methods: Fourteen CNI-t..
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Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients
Hae Min Lee, In-Ae Jang, Dongjae Lee, Eun Jin Kang, Bum Soon Choi, Cheol Whee Park, Yeong Jin Choi, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(6):865-872. Published online October 30, 2015
Background/Aims: BK virus-associated nephropathy (BKVAN) is an important cause of allograft dysfunction in kidney transplant recipients. It has an unfavorable clinical course, and no definite treatment guidelines have yet been established. Here, we report our center’s experience with biopsy-proven ..
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Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation
Sun Woo Lim, Ji Zhe Jin, Long Jin, Jian Jin, Can Li
Korean J Intern Med. 2015;30(6):759-770. Published online October 30, 2015
Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall..
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Limited immune tolerance induced by transient mixed chimerism
Ji Hyun Yu, Byung Ha Chung, Eun Ji Oh, Ji-Il Kim, Hee-Je Kim, In Sung Moon, Chul Woo Yang
Korean J Intern Med. 2015;30(5):735-738. Published online August 27, 2015
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Nephrology
Immunologic and non-immunologic complications of a third kidney transplantation
Hyun Seon Kim, Jae Young Kim, Eun Jin Kang, Yoon Seok Choi, Ji-Il Kim, In Sung Moon, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(5):657-664. Published online August 27, 2015
Background/Aims: Patients who undergo repeat kidney transplantations (KTs) are considered at high risk for experiencing immunologic and non-immunologic complications. In this study, we investigated the clinical outcomes, including medical and surgical complications, of patients who underwent a third..
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Recurrent neutropenia induced by rifabutin in a renal transplant recipient
Ji Yeun Chang, Eun Gyo Jeong, Ji Hyun Yu, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2014;29(4):532-534. Published online June 27, 2014
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Nephrology
Effects of pretransplant plasmapheresis and rituximab on recurrence of focal segmental glomerulosclerosis in adult renal transplant recipients
Hoon Suk Park, Yuah Hong, In O Sun, Byung Ha Chung, Hyung Wook Kim, Bum Soon Choi, Cheol Whee Park, Dong Chan Jin, Yong Soo Kim, Chul Woo Yang
Korean J Intern Med. 2014;29(4):482-488. Published online June 27, 2014
Background/Aims: Recurrent focal segmental glomerulosclerosis (FSGS) following renal transplantation is relatively common. However, the risk factors and optimal pretransplant treatment preventing recurrence of FSGS remain controversial.
Methods: We retrospectively reviewed 27 adult renal transplan..
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Clinical characteristics and outcomes in renal transplant recipients with renal cell carcinoma in the native kidney
In O Sun, Yu Mi Ko, Eun Young Kim, Kyung Seon Park, Hong Soon Jung, Sun Hye Ko, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yong Soo Kim, Chul Woo Yang
Korean J Intern Med. 2013;28(3):347-351. Published online May 1, 2013
Background/AimsWe investigated the incidence and clinical characteristics of renal cell carcinoma (RCC) in the native kidney of renal transplant recipients. MethodsBetween 1991 and 2010, 1,425 patients underwent kidney transplantation at our ins..
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