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Clinicopathologic Significance of Gastric and Intestinal Phenotypic Marker Expression in Gastric Carcinomas
Gwang Ha Kim, Geun Am Song, Do Youn Park, Dong Hyun Lee, Tae Oh Kim, Seong Hun Lee, Jeong Heo, Dae Hwan Kang, Mong Cho
Korean J Intern Med. 2005;20(3):191-197. Published online September 30, 2005
BackgroundIt is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal phenotypic marker expression patterns of tumors and the clinicopathologic ..
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Expression of Cyclooxygenase-2 and Bcl-2 in Human Gastric Adenomas
Jee Hyun Park, Kyung Hee Kang, Se Hwan Kim, Jong Hyup Lee, Chang Min Cho, Young Oh Kweon, Sung Kook Kim, Yong Hwan Choi, Han Ik Bae, Mi Sung Kim
Korean J Intern Med. 2005;20(3):198-204. Published online September 30, 2005
BackgroundCyclooxygenase (COX)-2 is the rate-limiting enzyme in prostaglandin synthesis. An increased expression has been implicated in the development and progression of human gastric cancers and colorectal adenomas and cancers. This study aimed to determine the involvement a..
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Irinotecan, Continuous 5-Fluorouracil, and Low dose of Leucovorin (modified FOLFIRI) as First Line of Therapy in Recurrent or Metastatic Colorectal Cancer
Myung-Ah Lee, Jae-Ho Byun, Byoung-Young Shim, In-Sook Woo, Jin-Hyung Kang, Young Seon Hong, Kyung Shik Lee, Myung Gyu Choi, Suk Kyun Chang, Seong Taek Oh, Sung Il Choi, Doo Suk Lee
Korean J Intern Med. 2005;20(3):205-209. Published online September 30, 2005
BackgroundIrinotecan, in combination with 5-fluorouracil (5-FU) and a high dose of leucovorin (LV), known as FOLFIRI regimen, has shown activity in recurrent or metastatic colorectal cancer. Therefore, we evaluated the efficacy and safety of irinotecan, 5-FU and a low dose of ..
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The Inverse Association Between the Presence of Antibody to Hepatitis B Surface Antigen and Atopy in Young Adults
Youngil I. Koh, Inseon S. Choi, Chang-Hwan Park, Jae-Sook Ahn, Seung-Gyu Ji
Korean J Intern Med. 2005;20(3):210-216. Published online September 30, 2005
BackgroundSome bacterial and viral infections may reduce the risk of atopy, and this is based on the concept of their ability to divert the immune system towards the Th1 responses. Most of the hepatitis B virus (HBV) infections occur in the developing countries and this is whe..
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Effect of High-Dose Intravenous N-acetylcysteine on the Concentration of Plasma Sulfur-Containing Amino Acids
Sae-Yong Hong, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Hyung-Kee Kim, Soo-Hyun Kim, Young-Ho Chung, Eun-Mi Lee, Soo-Kyung Hwang
Korean J Intern Med. 2005;20(3):217-223. Published online September 30, 2005
BackgroundThe purpose of this study was to determine the adequate loading and maintenance doses of N-acetylcyseteine (NAC) for patients suffering from acute ROS-induced injury. MethodsConcentrations of extra cellular NAC, cysteine (Cys), cystine..
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High-dose Versus Low-dose Cyclophosphamide in Combination with G-CSF for Peripheral Blood Progenitor Cell Mobilization
Jin Seok Ahn, Seonyang Park, Seock-Ah Im, Sung-Soo Yoon, Jong-Seok Lee, Byoung Kook Kim, Soo-Mee Bang, Eun Kyung Cho, Jae Hoon Lee, Chul Won Jung, Hugh Chul Kim, Chu Myung Seong, Moon Hee Lee, Chul Soo Kim, Keun Seok Lee, Jung Ae Lee, Myung-Ju Ahn
Korean J Intern Med. 2005;20(3):224-231. Published online September 30, 2005
BackgroundTo compare the mobilizing effects and toxicities of two different doses of cyclophosphamide (CY) plus lenograstim (glycosylated G-CSF), we performed a prospective randomized study by enrolling patients suffering with either high-risk Non-Hodgkin's lymphoma (NHL) or b..
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Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma
Jung-Mi Oh, Seung-Hyun Kim, Chang-Hee Suh, Dong-Ho Nahm, Hae-Sim Park, Young-Mok Lee, June-Hyuk Lee, Choon-Sik Park, Hyung-Doo Shin
Korean J Intern Med. 2005;20(3):232-236. Published online September 30, 2005
BackgroundGlutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be asso..
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Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study
Ock Bae Ko, Shin Kim, Hyeok Shim, Jung-Hun Lee, Jung-Min Ahn, Soon-Man Yoon, Min-Hyok Jeon, Il-No Do, So-young Lee, Yong Gil Kim, Sang We Kim, Sung-Bae Kim, Sang-Hee Kim, Jung Shin Lee, Wookun Kim, Chan-Jung Park, Hyun-sook Chi, Cheolwon Suh
Korean J Intern Med. 2005;20(3):237-242. Published online September 30, 2005
BackgroundAlthough high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially in the area of double ASCT. We present the results of an inst..
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| Case Reports |
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Delayed Ventricular Septal Rupture after Percutaneous Coronary Intervention in Acute Myocardial Infarction
Ji Young Park, Seong Hoon Park, Ji Young Oh, In Je Kim, Yu Hyun Lee, Si Hoon Park, Ki Hwan Kwon
Korean J Intern Med. 2005;20(3):243-246. Published online September 30, 2005
In the era before reperfusion therapy, ventricular septal rupture complicated 1~3% of acute myocardial infarctions (AMI) usually 3-5 days after onset. Studies have reported a positive correlation between the incidence of septal perforation and total occlusion of the coronary arteries. A 70-year o..
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A Case of Uterine Cervical Cancer Presenting with Granulocytosis
Heui June Ahn, Yeon Hee Park, Yoon Hwan Chang, Sun Hoo Park, Min-Suk Kim, Baek Yeol Ryoo, Sung Hyun Yang
Korean J Intern Med. 2005;20(3):247-250. Published online September 30, 2005
Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine c..
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Congenital Double-Orifice Mitral Valve with Mitral Regurgitation due to Flail Leaflet in an Elderly Patient
Shin-Jae Kim, Eun-Seok Shin, Sang-Gon Lee
Korean J Intern Med. 2005;20(3):251-254. Published online September 30, 2005
We report here on a case of double-orifice mitral valve with mitral regurgitation in a 75-year-old female who had complaints of mild dyspnea. Transthoracic and transesophageal echocardiography showed two orifices that were supplied by their own chordae from a different papillary muscle. Color Dop..
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A Case of Avascular Necrosis of the Femoral Head as Initial Presentation of Chronic Myelogenous Leukemia
Ji Yong Moon, Byung Su Kim, Hye Ryeon Yun, Jung Hye Choi, Young Yul Lee, In Soon Kim, Myung Ju Ahn
Korean J Intern Med. 2005;20(3):255-259. Published online September 30, 2005
Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hemopoietic stem cells characterized by abnormal proliferation and accumulation of immature granulocyte. Leukostasis is one of the complications of CML and is characterized by partial or total occlusion of microcirculation by ag..
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Cutaneous Metastases of Pancreatic Carcinoma as a First Clinical Manifestation
Dae Won Jun, Oh Young Lee, Chan Kum Park, Ho Soon Choi, Byung Chul Yoon, Min Ho Lee, Dong Hoo Lee
Korean J Intern Med. 2005;20(3):260-263. Published online September 30, 2005
Cutaneous metastases from pancreatic adenocarcinomas are rare lesions. The most common site of cutaneous metastasis is the umbilicus, and this is also known as the 'Sister Mary Joseph' nodule. A 68-year-old Korean male, who was previously healthy and asymptomatic, was seen in the dermatology depa..
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Adult Onset Still's Disease as a Cause of Acute Severe Mitral and Aortic Regurgitation
Jae Seung Lee, Il No Do, Deok Hyun Kang, Seok Jung Joo, Bin Yoo, Hee Bom Moon, Chang-Keun Lee
Korean J Intern Med. 2005;20(3):264-267. Published online September 30, 2005
Adult onset Still's disease (AOSD) is an uncommon acute systemic inflammatory disease of unknown origin. The clinical features include high spiking fever, arthralgia or arthritis, transient maculopapular rash, lymphadenopathy, hepatosplenomegaly, and serositis. Pericarditis is the most common car..
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Clear Cell Hepatocellular Carcinoma with Spontaneous Regression of Primary and Metastatic Lesions
Seong-Woo Jeon, Myung-Kwon Lee, Young-Doo Lee, Hyang-Eun Seo, Chang-Min Cho, Won-Young Tak, Young-Oh Kweon
Korean J Intern Med. 2005;20(3):268-273. Published online September 30, 2005
The prognosis of advanced hepatocellular carcinoma (HCC) tends to be poor. Spontaneous regression of this lesion is extremely rare. In this report, we describe a case of HCC which spontaneously regressed along with a metastatic lesion of the chest wall. A huge HCC in the right lobe, the largest ..
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