| Reviews |
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Endocrinology-metabolism
Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan
Korean J Intern Med. 2017;32(1):1-10. Published online January 1, 2017
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient complian..
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Nephrology
New therapeutic agents in diabetic nephropathy
Yaeni Kim, Cheol Whee Park
Korean J Intern Med. 2017;32(1):11-25. Published online January 1, 2017
Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and progression. Currently, there are few therapeutic drugs for DN, which mainly consist..
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Gastroenterology
Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus
Joon Ho Moon, Soo Heon Kwak, Hak C. Jang
Korean J Intern Med. 2017;32(1):26-41. Published online January 1, 2017
Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold hi..
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Rheumatology
CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells
Eun Ji Kim, Ki Ho Kang, Ji Hyeon Ju
Korean J Intern Med. 2017;32(1):42-61. Published online January 1, 2017
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly clustered regularly interspaced short palindromic repeats (CRISPR)—will allow us to impro..
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Endocrinology-metabolism
Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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| Editorial |
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| Original Articles |
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Gastroenterology
Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
Ji Yeon Kim, Dong Il Park, Dong Soo Han, Kyu-Chan Huh, Chang Kyun Lee, Jeong Eun Shin, Jae Hak Kim, You Sun Kim, Yunho Jung, Sung-Ae Jung, Hyun Joo Song, Hyun Joo Jang, Young-Ho Kim, Sung No Hong
Korean J Intern Med. 2017;32(1):69-78. Published online June 25, 2016
Background/Aims: The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea. Methods: A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The ba..
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The outcome of endoscopic management of bile leakage after hepatobiliary surgery
Seon Ung Yun, Young Koog Cheon, Chan Sup Shim, Tae Yoon Lee, Hyung Min Yu, Hyun Ah Chung, Se Woong Kwon, Taek Gun Jeong, Sang Hee An, Gyung Won Jeong, Ji Wan Kim
Korean J Intern Med. 2017;32(1):79-84. Published online July 8, 2016
Background/Aims: Despite improvements in surgical techniques and postoperative patient care, bile leakage can occur after hepatobiliary surgery and may lead to serious complications. The aim of this retrospective study was to evaluate the efficacy of endoscopic treatment of bile leakage after hepato..
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Cardiology
The predictive value of echocardiography for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism in Korea
Jin Sup Park, Jinhee Ahn, Jung Hyun Choi, Hye Won Lee, Jun-Hyok Oh, Han Cheol Lee, Kwang Soo Cha, Taek Jong Hong
Korean J Intern Med. 2017;32(1):85-94. Published online April 5, 2016
Background/Aims: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication after acute pulmonary embolism (APE) and is associated with substantial morbidity and mortality. This study aimed to investigate the incidence of CTEPH after APE in Korea and to determine echoca..
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Pulmonology
Risk factors associated with provoked pulmonary embolism
Endri Gjonbrataj, Ji Na Kim, Juarda Gjonbrataj, Hye In Jung, Hyun Jung Kim, Won-Il Choi
Korean J Intern Med. 2017;32(1):95-101. Published online April 21, 2016
Background/Aims: This study aimed to investigate the risk factors associated with provoked pulmonary embolism (PE). Methods: This retrospective cohort study included 237 patients with PE. Patients that had transient risk factors at diagnosis were classified as having provoked PE, with the remaining ..
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Endocrinology-metabolism
Serum vitamin D3 levels are not associated with thyroid cancer prevalence in euthyroid subjects without autoimmune thyroid disease
Yun Mi Choi, Won Gu Kim, Tae Yong Kim, Sung Jin Bae, Hong-Kyu Kim, Eun Kyung Jang, Min Ji Jeon, Ji Min Han, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(1):102-108. Published online September 1, 2016
Background/Aims: Previous studies have suggested that elevated serum vitamin D levels might protect against thyroid cancer. Elevated serum thyroid stimulating hormone levels and autoimmune thyroid disease (AITD) are suggested to be thyroid cancer promoting factors but have not been well controlled i..
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Nephrology
The impact of high serum bicarbonate levels on mortality in hemodialysis patients
Kyung Yoon Chang, Hyung Wook Kim, Woo Jeong Kim, Yong Kyun Kim, Su-Hyun Kim, Ho Chul Song, Young Ok Kim, Dong Chan Jin, Euy Jin Choi, Chul Woo Yang, Yong-Lim Kim, Nam-Ho Kim, Shin-Wook Kang, Yon-Su Kim, Young Soo Kim
Korean J Intern Med. 2017;32(1):109-116. Published online April 5, 2016
Background/Aims: The optimal serum bicarbonate level is controversial for patients who are undergoing hemodialysis (HD). In this study, we analyzed the impact of serum bicarbonate levels on mortality among HD patients. Methods: Prevalent HD patients were selected from the Clinical Research Center re..
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Which dialysis unit blood pressure is the most accurate for predicting home blood pressure in patients undergoing hemodialysis?
In-Cheol Yoon, Hye-Min Choi, Dong-Jin Oh
Korean J Intern Med. 2017;32(1):117-124. Published online April 7, 2016
Background/Aims: We investigated which dialysis unit blood pressure (BP) is the most useful for predicting home BP in patients undergoing hemodialysis (HD). Methods: Patients undergoing HD who had been treated > 3 months were included in this study. Exclusion criteria were hospitalized patients with..
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Hemato-oncology
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Allergy
Relationship between serum IgA level and allergy/asthma
Woo-Jin Kim, Inseon S. Choi, Chang Seong Kim, Jeong-Hyeon Lee, Hyeon-Wook Kang
Korean J Intern Med. 2017;32(1):137-145. Published online September 2, 2016
Background/Aims: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR). Methods: The clinical records of 1,136 adul..
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Infectious diseases
Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections
So Yeon Park, Cheol-In Kang, Yu Mi Wi, Doo Ryeon Chung, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2017;32(1):146-157. Published online April 20, 2016
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
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Rheumatology
Characteristics of hip involvement in patients with ankylosing spondylitis in Korea
Hyemin Jeong, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
Korean J Intern Med. 2017;32(1):158-164. Published online March 25, 2016
Background/Aims: To evaluate the clinical course of hip arthritis and the risk factors for hip joint replacement in patients with ankylosing spondylitis (AS). Methods: In this retrospective analysis, we evaluated 488 AS patients at a single tertiary hospital. At baseline and the most recent visit to..
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Autonomic dysfunction in primary Sjogren’s syndrome: a prospective cohort analysis of 154 Korean patients
Jung Hee Koh, Seung-Ki Kwok, Jennifer Lee, Sung-Hwan Park
Korean J Intern Med. 2017;32(1):165-173. Published online March 25, 2016
Background/Aims: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren’s syndrome (pSS) and its associations with the clinical features of pSS. Methods: We analyzed 154 participants from the Korean Initiative of primary Sjogren’s Syndrome (KISS) as a pros..
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| Letters to the editor |
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Recurrent pyogenic liver abscess as a presenting manifestation of colorectal cancer
Hee Yeon Kim, Chang Wook Kim, Dong Ryul Kim, Young Wook Cho, Jae-Young Cho, Woo Jung Kim, Hyung Gyu Choi
Korean J Intern Med. 2017;32(1):174-177. Published online February 3, 2016
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A novel c.563 T>G, p.L189R lamin A/C mutation in identical twins with dilated cardiomyopathy
Euijae Lee, Kyung-Taek Park, Jinwoo Kang, Hyunkyung Park, Jin Joo Park, Il-Young Oh, Yeonyee E. Yoon
Korean J Intern Med. 2017;32(1):178-181. Published online March 8, 2016
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Presence of bilirubin in bronchobiliary fistula easily confirmed with urinary dipstick test and treated with embolization
Min Je Kim, Seon Hye Kim, In Kyoung Hwang, Hyung Oh Kim, Na Eun Jang, Seung Sook Paik, Myung Jae Park
Korean J Intern Med. 2017;32(1):182-185. Published online January 1, 2017
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Minimal change nephrotic syndrome showing complete remission after resection of a neurofibroma in a type I neurofibromatosis patient
Ji In Hyun, Ji Won Min, Hye Min Lee, Yong Kyun Kim, Eu Jin Choi, Ho Cheol Song
Korean J Intern Med. 2017;32(1):186-189. Published online March 8, 2016
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Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer
Sung Young Moon, Kang Hoon Lee, Jong Sik Lee, Hyun Suk Yang, Hong Ghi Lee, Yo Han Cho, So Young Yoon
Korean J Intern Med. 2017;32(1):190-194. Published online February 3, 2016
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| Images of interest |
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Proton pump inhibitor-induced fundic gland polyposis
Young Joo Park, Gwang Ha Kim
Korean J Intern Med. 2017;32(1):197-198. Published online January 1, 2017
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| Guideline |
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Evidence-based guidelines for fall prevention in Korea
Kwang-Il Kim, Hye-Kyung Jung, Chang Oh Kim, Soo-Kyung Kim, Hyun-Ho Cho, Dae Yul Kim, Yong-Chan Ha, Sung-Hee Hwang, Chang Won Won, Jae-Young Lim, Hyun Jung Kim, Jae Gyu Kim; The Korean Association of Internal Medicine, The Korean Geriatrics Society
Korean J Intern Med. 2017;32(1):199-210. Published online January 1, 2017
Falls and fall-related injuries are common in older populations and have negative effects on quality of life and independence. Falling is also associated with increased morbidity, mortality, nursing home admission, and medical costs. Korea has experienced an extreme demographic shift with its popula..
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| Retraction |
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Hepatic hydatid cyst
Keum Nahn Jee
Korean J Intern Med. 2017;32(1):211-211. Published online January 1, 2017
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