| Reviews |
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Pulmonology
Modifiers of TGF-b1 effector function as novel therapeutic targets of pulmonary fibrosis
Chang-Min Lee, Jin Wook Park, Won-Kyung Cho, Yang Zhou, Boram Han, Pyoung Oh Yoon, Jeiwook Chae, Jack A Elias, Chun Geun Lee
Korean J Intern Med. 2014;29(3):281-290. Published online April 29, 2014
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-b1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs including skin, liver, kidney, and lung. Thus, TGF-b1 and its signaling pathways have been at..
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Nephrology
The renin-angiotensin system and aging in the kidney
Hye Eun Yoon, Bum Soon Choi
Korean J Intern Med. 2014;29(3):291-295. Published online April 29, 2014
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney..
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| Editorials |
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A disappearing vertical infection: will hepatitis B be a forgotten disease in children?
Byung-Ho Choe
Korean J Intern Med. 2014;29(3):296-300. Published online April 29, 2014
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Is amlodipine more cardioprotective than other antihypertensive drug classes?
Chang Gyu Park
Korean J Intern Med. 2014;29(3):301-304. Published online April 29, 2014
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Clinical implications of follicular and Hurthle cell carcinoma in an iodine-sufficient area
Dong Yeob Shin, Young Suk Jo
Korean J Intern Med. 2014;29(3):305-306. Published online April 29, 2014
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| Original Articles |
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Gastroenterology
Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital
Jae Hoon Kim, Ju Seung Kim, Jong Joon Lee, Jung Ho Kim, Suk Young Kim, Young Kul Jung, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim
Korean J Intern Med. 2014;29(3):307-314. Published online April 29, 2014
Background/Aims: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in ..
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Cardiology
Amlodipine and cardiovascular outcomes in hypertensive patients: meta-analysis comparing amlodipine-based versus other antihypertensive therapy
Seung-Ah Lee, Hong-Mi Choi, Hye-Jin Park, Su-Kyoung Ko, Hae-Young Lee
Korean J Intern Med. 2014;29(3):315-324. Published online April 29, 2014
Background/Aims: This meta-analysis compared the effects of amlodipine besylate, a charged dihydropyridine-type calcium channel blocker (CCB), with other non-CCB antihypertensive therapies regarding the cardiovascular outcome.
Methods: Data from seven long-term outcome trials compa..
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Endocrinology-metabolism
Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data
Won Gu Kim, Tae Yong Kim, Tae Hyuk Kim, Hye Won Jang, Young Suk Jo, Young Joo Park, Sun Wook Kim, Won Bae Kim, Minho Shong, Do Joon Park, Jae Hoon Chung, Young Kee Shong, Bo Youn Cho
Korean J Intern Med. 2014;29(3):325-333. Published online April 29, 2014
Background/Aims: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma (HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine- sufficient areas. In this study we evaluated the clinical behavior, prognostic factors and treatment outcomes of FTC and HCC in Korea.
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Nephrology
Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy
Jae Ryung Shin, Seung Min Kim, Jung Sun Yoo, Ji Yoon Park, Seul Ki Kim, Joo Hee Cho, Kyung Hwan Jeong, Tae Won Lee, Chun Gyoo Ihm
Korean J Intern Med. 2014;29(3):334-340. Published online April 29, 2014
Background/Aims: β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a bio..
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A mild decrease of renal function is related to increased hemoglobin level during 5-year follow-up period
Nara Shin, Hyunsuk Kim, Hyo Jin Kim, Miyeun Han, Sunhwa Lee, Hyungah Jo, Huh Hyuk, Ho Jun Chin
Korean J Intern Med. 2014;29(3):341-351. Published online April 29, 2014
Background/Aims: We analyzed chronological changes in hemoglobin according to renal function changes over a 5-year follow-up period.
Methods: We enrolled 5,266 adults with a glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 at an initial examination at a routine heal..
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Hemato-oncology
Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer’s ring: nationwide Korean study
Seong Jun Lee, Cheol Won Suh, Soon Il Lee, Won Seog Kim, Won Sik Lee, Hyo Jung Kim, Chul Won Choi, Jin Seok Kim, Jin Seok Kim, Ho-Jin Shin, Ho-Jin Shin, The Consortium for Improving Survival of Lymphoma , The Consortium for Improving Survival of Lymphoma
Korean J Intern Med. 2014;29(3):352-360. Published online April 29, 2014
Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer’s ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectiv..
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Rheumatology
Clinical factors and treatment outcomes associated with failure in the detection of urate crystal in patients with acute gouty arthritis
Jun Won Park, Dong Jin Ko, Jong Jin Yoo, Sung Hae Chang, Hyon Joung Cho, Eun Ha Kang, Jin Kyun Park, Yeong Wook Song, Yun Jong Lee
Korean J Intern Med. 2014;29(3):361-369. Published online April 29, 2014
Background/Aims: To investigate the rate of detection of monosodium urate (MSU) crystals in the synovial fluid (SF) of patients with acute gouty arthritis and factors associated with false-negative results.
Methods: A total of 179 patients with acute gouty arthritis who had undergo..
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| Case Reports |
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Cryptococcal meningitis in a patient with chronic hepatitis C treated with pegylated-interferon and ribavirin
Tae-Hee Lee, Kee-Ook Lee, Yong-Seok Kim, Sun-Moon Kim, Kyu-Chan Huh, Young-Woo Choi, Young-Woo Kang
Korean J Intern Med. 2014;29(3):370-374. Published online April 29, 2014
Various adverse events have been reported during combination therapy with pegylated (PEG)-interferon-α and ribavirin, although opportunistic infections, especially cryptococcal meningitis, are very rare. A 61-year-old woman complained of headaches and a fever during treatment of a chronic hepatiti..
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A case of ampullary gangliocytic paraganglioma
Ju-Il Yang, Jung-Sik Choi, Ga-Hee Lee, Byeong-Woo Kim, Seok-Jun Moon, Mi Seon Kang, Hyo Jung Ahn
Korean J Intern Med. 2014;29(3):375-378. Published online April 29, 2014
Gangliocytic paragangliomas (GPs) are rare tumors of the duodenum, presenting as single sessile or pedunculated polypoid masses. Clinical manifestations of duodenal GPs can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdom..
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Acute esophageal necrosis occurring in a patient undergoing percutaneous coronary intervention
Hyung-Jin Kwon, Sang-Ho Park, Ji-Hoon Ahn, Tae-Hoon Lee, Chang-Kyun Lee
Korean J Intern Med. 2014;29(3):379-382. Published online April 29, 2014
Acute esophageal necrosis is uncommon in the literature. Its etiology is unknown, although cardiovascular disease, hemodynamic compromise, gastric outlet obstruction, alcohol ingestion, hypoxemia, hypercoagulable state, infection, and trauma have all been suggested as possible causes. A 67-year-old ..
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Distant subcutaneous recurrence of a parathyroid carcinoma: abnormal uptakes in the 99mTc-sestamibi scan and 18F-FDG PET/CT imaging
Sang Soo Kim, Yun Kyung Jeon, Soo Hyung Lee, Bo Hyun Kim, Seong Jang Kim, Yong Ki Kim, In Ju Kim
Korean J Intern Med. 2014;29(3):383-387. Published online April 29, 2014
We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50‑year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a 99mTc-s..
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| Letters to the editor |
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A case of Wegener’s granulomatosis mimicking recurrent hemophagocytic lymphohistiocytosis
Sung Min Jung, Yun Hwa Jung, Hyun Jin Noh, In Sook Woo, Chi Wha Han
Korean J Intern Med. 2014;29(3):393-397. Published online April 29, 2014
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Native valve endocarditis due to extended spectrum β-lactamase producingKlebsiella pneumoniae
Hyun-Ae Jung, Young Eun Ha, Damin Kim, Jihyun Park, Cheol-In Kang, Doo Ryeon Chung, Seung Woo Park, Ki Ik Sung, Jae-Hoon Song, Kyong Ran Peck
Korean J Intern Med. 2014;29(3):398-401. Published online April 29, 2014
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Unusual metatarsophalangeal joint deformity in an advanced rheumatoid foot
Seung-Min Jung, Jae Hoon Ahn, Sung-Hwan Park, Kyung-Su Park
Korean J Intern Med. 2014;29(3):402-403. Published online April 29, 2014
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| Images of interest |
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Detection of calcium pyrophosphate dihydrate crystal deposition disease by dual-energy computed tomography
Hae-Rim Kim, Jung-Hwa Lee, Na Ra Kim, Sang-Heon Lee
Korean J Intern Med. 2014;29(3):404-405. Published online April 29, 2014
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Unusual cause of back pain in a 13-year-old boy: a thoracic osteoblastoma
Seok Won Kim, Hyun-Sook Kim
Korean J Intern Med. 2014;29(3):406-407. Published online April 29, 2014
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