Klotho and the Aging Process
Makoto Kuro-o
Korean J Intern Med. 2011;26(2):113-122.   Published online 2011 Jun 1     DOI: https://doi.org/10.3904/kjim.2011.26.2.113
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Christian Schnedl, Astrid Fahrleitner-Pammer, Peter Pietschmann, Karin Amrein
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Experimental Dermatology.2013; 22(11): 772.     CrossRef
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P. M. Engelfriet, E. H. J. M. Jansen, H. S. J. Picavet, M. E. T. Dolle
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