KJIM :: Korean Journal of Internal Medicine

Morusin suppresses the stemness characteristics of gastric cancer cells induced by hypoxic microenvironment through inhibition of HIF-1α accumulation

Mo Chen, Shufeng Xiao, Ping Sun, Yongfu Li, Zhixing Xu, Jun Wang

Cabozantinib in combination with immune checkpoint inhibitors for renal cell carcinoma: a systematic review and meta-analysis

Jingyang Su, Jialin Zhang, Yuqian Wu, Cui Ni, Yueyue Ding, Zelin Cai, Ming Xu, Mingyang Lai, Jue Wang, Shengyou Lin, Jinhua Lu

Journal of Gastrointestinal Cancer.2023; 54(1): 204. CrossRef

Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial–mesenchymal transition through the Wnt/β-catenin signaling pathway

PanFeng Feng, LongXun Zhu, Jing Jie, PengXiang Yang, Nan Sheng, XiangFan Chen, Xia Chen

Journal of Cancer Research and Clinical Oncology.2023; 149(7): 3587. CrossRef

IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation

Sunny Li-Yun Chang, Chiang-Wen Lee, Chen-Yu Yang, Zih-Chan Lin, Kuo-Ti Peng, Shih-Chia Liu, Shih-Wei Wang, Hsiao-Chi Tsai, Yi-Chin Fong, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Chih-Yuan Ko, Ju-Fang Liu, Chih-Hsin Tang

Biochemical Pharmacology.2023; 210: 115472. CrossRef

Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma

Expert Reviews in Molecular Medicine.2023;[Epub] CrossRef

Spontaneous spheroids from alveolar bone-derived mesenchymal stromal cells maintain pluripotency of stem cells by regulating hypoxia-inducible factors

Ni Li, Xiaofeng Dai, Fei Yang, Yang Sun, Xingwen Wu, Qianrong Zhou, Kai Chen, Jian Sun, Wei Bi, Le Shi, Youcheng Yu

Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets

José Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martínez, Ángelo Torres, Rody San Martín, Juan Carlos Roa, Claudia Quezada-Monrás

International Journal of Molecular Sciences.2023; 24(8): 7047. CrossRef

Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens

Nityanand Srivastava, Salman Sadullah Usmani, Rajasekaran Subbarayan, Rashmi Saini, Pranav Kumar Pandey

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva, Timur Fatkhudinov

Journal of Personalized Medicine.2023; 13(11): 1616. CrossRef

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Xiya Jia, Bing Chen, Ziteng Li, Shenglin Huang, Siyuan Chen, Runye Zhou, Wanjing Feng, Hui Zhu, Xiaodong Zhu

Hypoxia induces radioresistance, epithelial‑mesenchymal transition, cancer stem cell‑like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma

Emilia Wiechec, Natasa Matic, Ashfaq Ali, Karin Roberg

Epithelial‐to‐mesenchymal‐like transition events in melanoma

Dennis Pedri, Panagiotis Karras, Ewout Landeloos, Jean‐Christophe Marine, Florian Rambow

Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges

Zhenyu Nie, Mei Chen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Fei Wang, Shufang Zhang

Hypoxic Signaling Is Modulated by Calcium Channel, CaV1.3, in Androgen-Resistant Prostate Cancer

Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis

Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef

Cancer stem cells and tumor heterogeneity: Deciphering the role in tumor progression and metastasis

New Therapeutic Interventions for Kidney Carcinoma: Looking to the Future

Lucio Dell’Atti, Nicoletta Bianchi, Gianluca Aguiari

Cancer Stem Cells and the Tumor Microenvironment: Targeting the Critical Crosstalk through Nanocarrier Systems

Aadya Nayak, Neerada Meenakshi Warrier, Praveen Kumar

Stem Cell Reviews and Reports.2022; 18(7): 2209. CrossRef

An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer

Yuan-jie Liu, Jie-pin Li, Hui-ru Li, Shu-hong Zeng, Yu-gen Chen, Mei Han, Qian-wen Ye, Jin-yong Zhou, Shen-lin Liu, Xi Zou

TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma

Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan

EMT, cancer stem cells and autophagy; The three main axes of metastasis

Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Nasrin Zare Zavieyh Jaghi

Biomedicine & Pharmacotherapy.2021; 133: 110909. CrossRef

The CXCL12 Crossroads in Cancer Stem Cells and Their Niche

Juan Carlos López-Gil, Laura Martin-Hijano, Patrick C. Hermann, Bruno Sainz

5-Aza-2’-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment

Ísis Salviano Soares de Amorim, Juliana Alves Rodrigues, Pedro Nicolau, Sandra König, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha

Molecular Biology Reports.2021; 48(2): 1161. CrossRef

The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients

Astrid Børretzen, Karsten Gravdal, Svein A Haukaas, Monica Mannelqvist, Christian Beisland, Lars A Akslen, Ole J Halvorsen

The Journal of Pathology: Clinical Research.2021; 7(3): 253. CrossRef

HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

Diana Gaete, Diego Rodriguez, Deepika Watts, Sundary Sormendi, Triantafyllos Chavakis, Ben Wielockx

Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells

Yong Zhang, Li Jiang, Nianqun Qin, Mi Cao, Xiujuan Liang, Rensheng Wang

Biochemistry and Cell Biology.2021; 99(2): 203. CrossRef

Pluripotency inducing Yamanaka factors: role in stemness and chemoresistance of liver cancer

Expert Review of Anticancer Therapy.2021; 21(8): 853. CrossRef

The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance

Srishti Jain, Stephanie L. Annett, Maria P. Morgan, Tracy Robson

International Journal of Molecular Sciences.2021; 22(8): 4091. CrossRef

Cancer stem cell characteristics and their potential as therapeutic targets

Jacqueline R. Lim, Josette Mouawad, Olivia K. Gorton, William A. Bubb, Ann H. Kwan

Hypoxia in Lung Cancer Management: A Translational Approach

Julien Ancel, Jeanne-Marie Perotin, Maxime Dewolf, Claire Launois, Pauline Mulette, Béatrice Nawrocki-Raby, Véronique Dalstein, Christine Gilles, Gaëtan Deslée, Myriam Polette, Valérian Dormoy

Elevated LncRNA TRERNA1 correlated with activation of HIF-1α predicts poor prognosis in hepatocellular carcinoma

Yanyan Qian, Yiping Li, Yanping Ge, Wei Song, Hong Fan

Pathology - Research and Practice.2021; 227: 153612. CrossRef

Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis

Saima Usman, Naushin H. Waseem, Thuan Khanh Ngoc Nguyen, Sahar Mohsin, Ahmad Jamal, Muy-Teck Teh, Ahmad Waseem

Prolonged hypoxia switched on cancer stem cell-like plasticity in HepG2 tumourspheres cultured in serum-free media

In Vitro Cellular & Developmental Biology - Animal.2021; 57(9): 896. CrossRef

Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors

Leila Jahangiri, Perla Pucci, Tala Ishola, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner

Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer

Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-Panabières

Molecular Aspects of Medicine.2020; 72: 100816. CrossRef

Hypoxia modulates stem cell properties and induces EMT through N‐glycosylation of EpCAM in breast cancer cells

Dandan Zhang, Liu Yang, Xue Liu, Jiujiao Gao, Tingjiao Liu, Qiu Yan, Xuesong Yang

Journal of Cellular Physiology.2020; 235(4): 3626. CrossRef

Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms

Wafaa S. Ramadan, Dana M. Zaher, Alaa M. Altaie, Iman M. Talaat, Adel Elmoselhi

International Journal of Molecular Sciences.2020; 21(2): 565. CrossRef

Genome-wide analysis of the hypoxia-related DNA methylation-driven genes in lung adenocarcinoma progression

Antioxidants & Redox Signaling.2020; 32(10): 715. CrossRef

Novel Therapeutic Strategies for Ovarian Cancer Stem Cells

Nastassja Terraneo, Francis Jacob, Anna Dubrovska, Jürgen Grünberg

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma

Guangsong Xu, Mingliang Li, Jiang Wu, Chunhong Qin, Yin Tao, Hongjie He

Cancer Management and Research.2020; Volume 12: 2789. CrossRef

The Role of Epithelial-to-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma

Current Treatment Options in Oncology.2020;[Epub] CrossRef

Dehydroeffusol inhibits hypoxia-induced epithelial–mesenchymal transition in non-small cell lung cancer cells through the inactivation of Wnt/β-catenin pathway

Haitao Wei, Feng Zhang, Jiali Wang, Min Zhao, Tao Hou, Li Li

TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer

Bit Na Kim, Dong Hyuck Ahn, Nahyeon Kang, Chang Dong Yeo, Young Kyoon Kim, Kyo Young Lee, Tae-Jung Kim, Sug Hyung Lee, Mi Sun Park, Hyeon Woo Yim, Jong Y. Park, Chan Kwon Park, Seung Joon Kim

Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective

Beatrice Aramini, Valentina Masciale, Khawaja Husnain Haider

World Journal of Stem Cells.2020; 12(6): 406. CrossRef

Aldolase A promotes epithelial‐mesenchymal transition to increase malignant potentials of cervical adenocarcinoma

Yuki Saito, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Taishi Akimoto, Misaki Ota, Kazufumi Magara, Masaki Murata, Yoshihiko Hirohashi, Tadashi Hasegawa, Norimasa Sawada, Tsuyoshi Saito, Makoto Osanai

Cancer stem cell and mesenchymal cell cooperative actions in metastasis progression and hormone resistance in prostate cancer: Potential role of androgen and gonadotropin‑releasing hormone receptors (Review)

H�ctor Contreras, Fernanda L�pez‑Moncada, Enrique Castell�n

International Journal of Oncology.2020;[Epub] CrossRef

Colorectal Cancer Stem Cells in the Progression to Liver Metastasis

Carlos A. Gonzalez-Villarreal, Adriana G. Quiroz-Reyes, Jose F. Islas, Elsa N. Garza-Treviño

In Vitro Innovation of Tendon Tissue Engineering Strategies

Maria Rita Citeroni, Maria Camilla Ciardulli, Valentina Russo, Giovanna Della Porta, Annunziata Mauro, Mohammad El Khatib, Miriam Di Mattia, Devis Galesso, Carlo Barbera, Nicholas R. Forsyth, Nicola Maffulli, Barbara Barboni

International Journal of Molecular Sciences.2020; 21(18): 6726. CrossRef

Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment

Debolina Ganguly, Raghav Chandra, John Karalis, Martha Teke, Todd Aguilera, Ravikanth Maddipati, Megan B. Wachsmann, Dario Ghersi, Giulia Siravegna, Herbert J. Zeh, Rolf Brekken, David T. Ting, Matteo Ligorio

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance

Dimas Carolina Belisario, Joanna Kopecka, Martina Pasino, Muhlis Akman, Enrico De Smaele, Massimo Donadelli, Chiara Riganti

Hypoxia-Mediated Decrease of Ovarian Cancer Cells Reaction to Treatment: Significance for Chemo- and Immunotherapies

Aleksandra Klemba, Lubomir Bodnar, Halina Was, Klaudia K. Brodaczewska, Gabriel Wcislo, Cezary A. Szczylik, Claudine Kieda

International Journal of Molecular Sciences.2020; 21(24): 9492. CrossRef

MODERN CONCEPTS ON THE ROLE OF HYPOXIA IN THE DEVELOPMENT OF TUMOR RADIORESISTANCE

M. A. Senchukova, E. V. Makarova, E. A. Kalinin, V. V. Tkachev, E. Y. Zubareva

Siberian journal of oncology.2020; 19(6): 141. CrossRef

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Casper Reijnen, Willem Jan van Weelden, Martijn S. J. P. Arts, Johan P. Peters, Paul F. Rijken, Koen van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, Eva Colas, Antonio Gil-Moreno, Armando Reques, Gemma Mancebo, Camilla Kraks

British Journal of Cancer.2019; 120(11): 1037. CrossRef

Epithelial-to-mesenchymal transition in thyroid cancer: a comprehensive review

Heewa Shakib, Sadegh Rajabi, Mohammad Hossien Dehghan, Farideh Jalali Mashayekhi, Nahid Safari-Alighiarloo, Mehdi Hedayati

Red Blood Cell-Membrane-Coated Poly(Lactic-co-glycolic Acid) Nanoparticles for Enhanced Chemo- and Hypoxia-Activated Therapy

Anil Parsram Bidkar, Pallab Sanpui, Siddhartha Sankar Ghosh

ACS Applied Bio Materials.2019; 2(9): 4077. CrossRef

Hypoxia induced cancer stem cell enrichment promotes resistance to androgen deprivation therapy in prostate cancer

Debbie O'Reilly, Patricia Johnson, Paul J. Buchanan

Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Naïve Prostate Carcinomas Undergoing Radical Prostatectomy

Smentoch, Szade, Żaczek, Eltze, Semjonow, Brandt, Bednarz-Knoll

Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression

Carlos Velásquez, Sheila Mansouri, Olga Gutiérrez, Yasin Mamatjan, Pilar Mollinedo, Shirin Karimi, Olivia Singh, Nuria Terán, Juan Martino, Gelareh Zadeh, José L. Fernández-Luna

The Tumor Vessel Targeting Strategy: A Double-Edged Sword in Tumor Metastasis

Xiaobo Li, Yong Li, Weijin Lu, Minfeng Chen, Wencai Ye, Dongmei Zhang

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Intratumor heterogeneity in epigenetic patterns

Seminars in Cancer Biology.2018; 51: 12. CrossRef

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

Ernestina M. De Francesco, Federica Sotgia, Michael P. Lisanti

Chemoresistance and the Self-Maintaining Tumor Microenvironment

Gulcen Yeldag, Alistair Rice, Armando Del Río Hernández