1. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC. Mutation preventing formation of hepatitis Be antigen in patients with CH-B infection. Lancet 1989;2:588–591.
2. Brunetto M, Stemler M, Schodel F, Bonino F. Identification of an HBV variant which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Ital J Gastroenterol 1989;21:151–154.
3. Tong S, Li J, Vitvitski L, Trepo C. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 1990;176:596–603.
4. Santantonio T, Jung M-C, Miska S, Pastore G, Pape GR, Will H. Prevalence and type of pre-C HBV mutants in anti-HBe positive carriers with chronic liver disease in a highly endemic area. Virology 1991;183:840–844.
5. Carman WF, Ferrao M, Lok ASF, Ma OCK, Lai CL, Thomas HC. Precore sequence variation in Chinese isolates of hepatitis B virus. J Infect Dis 1991;165:127–133.
6. Naoumov NV, Schneider R, Grotzinger T, Jung MC, Miska S, Pape GR, Will H. Precore mutants hepatitis B virus infection and liver disease. Gastroenterology 1992;102:538–543.
9. Carman WF, McIntyre G, Hadziyannis S, Fattovich G, Alberti A, Thomas HC. Core protein evolution after selection of hepatitis B precore mutants and correlation with disease severity. In: Nishioka K, Suzuki H, Mishiro D, Oda T, eds. Viral Hepatitis and Liver Disease. Springer-Verlag, 1994;273–276.
10. Peters M, Vierling J, Gershwin ME, Milich D, Chisari FV, Hoofnagle JH. Immunology and the liver. Hepatology 1991;13:977–994.
11. Ferrari C, Penna A, Glugerci T, Tong MJ, Ribera E, Fiaccadori F, Chisari FV. Intrahepatic, nucleocapsid antigen-specific T cell in chronic active hepatitis B. J Immunol 1987;139:2050–2058.
12. Van Bleek GM, Nathenson SG. Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule. Nature 1990;348:213–216.
13. Rotzschke O, Falk K, Deres K, Shild H, Norda M, Metzger J, Jung G, Rammensee HG. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 1990;348:252–254.
15. Chuang W-L, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu S-N, Chang W-Y, Ohto M. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 1993;104:263–271.
16. Kim CY, Lee H-S, Yim KW. HBsAg+ and HBsAg- chronic active hepatitis, liver cirrhosis and hepatocellular carcinoma in Korea; Prevalence and difference in age distribution. Seoul J Med 1992;33:127–131.
17. Kim KT, Hyun SW, Kim YS, Rho HM. Complete nucleotide sequence of hepatitis B virus (subtype adr). Korean J Biochem 1988;21:319–331.
18. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989;339:237–238.
19. Carothers AM, Urlaub G, Mucha J, Grunberger D, Chasin LA. Point mutation analysis in a mammalian gene: Rapid preparation of total RNA. PCR amplfication of cDNA, and Taq sequencing by a novel method. Bio Techniques 1989;7:494–499.
20. Hedden V, Callen W, Short JM, Kretz K. Improved sequence analysis of mutations identified with the Big Blue System: New protocol can be completed in 2 days. Strategies in Mol Biol 1993;6:27–28.
21. Kobayashi M, Koike K. Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization. Gene 1984;30:227–232.
24. Domingo E, Sabo D, Tanichi T, Weissmann C. Nuceotide sequence heterogeneity of a RNA phage population. Cell 1978;13:735–744.
25. Domingo E, Martinez-Salas E, Sobrino F, et al. The quasispecies (extremely heterogenous) nature of viral RNA genome populations: Biological relevance-a review. Gene 1985;40:1–8.
26. Pircher H, Moskophidis D, Rohrer U, Burki K, Hengartner H, Zinkernagel RM. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 1990;346:629–633.
27. Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CRM, Rizza CR, McMichael AJ. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991;354:453–459.
28. Lee H-S, Ulrich P, Vyas GN. Mutations in the S-gene affecting the immunologic determinant of the envelope protein of hepatitis B virus. J Hepatol 1991;13(Suppl 4):S97–101.
29. Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses. Annu Rev Biochem 1987;56:651–693.
30. Miller RH, Kaneko S, Chung CT, Girones R, Purcell RH. Compact organization of the hepatitis B virus genome. Hepatology 1989;9:322–327.
31. Falk K, Rotzschke O, Stevanovic S, Jung G, Rammensee HG. Allele-specific motif revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991;351:290–296.
33. Kumagai M. Genetic factors (HLA) and cellular immunity in the pathogenesis of asymptomatic HBsAg carrier. Act Hepatol Jpn 1979;20:339–345.
34. Lin DY, Liaw YF, Chu CM, Chen GH. Histocompatibility profile of hepatoma in Taiwan. J Formosan Med Assoc (Taiwan I Hseuh Hui T sa Chih) 1982;81:1126–1131.
35. Ehata T, Omata M, Chuang W-L, Yokosuka O, Ito Y, Hosoda K, Ohto M. Mutations in the core nucleotide sequence of hepatitis B virus correlate with severe liver damage. In: Nishioka K, Suzuki H, Mishiro D, Oda T, eds. Viral Hepatitis and Liver Disease. Springer-Verlag, 1994;277–282.
36. Bertoletti A, Chisari FV, Penna A, Guilhot S, Galati L, Missale G, Fowler P, Schlicht H-J, Vitiello A, Chesnut RC, Fiaccadori F, Ferrari C. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993;67:2376–2380.