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Korean J Intern Med > Volume 31(4); 2016 > Article
Joo, Yeom, Ha, Park, Lee, Kim, Kang, Chung, Song, and Peck: Diagnostic yield of computed tomography-guided bone biopsy and clinical outcomes of tuberculous and pyogenic spondylitis



This study aimed to evaluate the efficacy of computed tomography (CT)-guided bone biopsy for the diagnosis of spinal infection and compared the clinical outcomes between tuberculous and pyogenic spinal infections.


The retrospective cohort study included patients who received CT-guided bone biopsy at a tertiary hospital over the 13 years.


Among 100 patients, 67 had pyogenic spondylitis and 33 had tuberculous spondylitis. Pathogens were isolated from bone specimens obtained by CT-guided biopsy in 42 cases, with diagnostic yields of 61% (20/33) for tuberculous spondylitis and 33% (22/67) for pyogenic spondylitis. For 36 culture-proven pyogenic cases, Staphylococcus aureus was the most commonly isolated organism. Patients with pyogenic spondylitis more frequently presented with fever accompanied by an increase in inflammatory markers than did those with tuberculosis. Among all patients who underwent surgery, the incidence of late surgery performed one month after diagnosis was higher in patients with tuberculous infection (56.3%) than in those with pyogenic disease (23.3%, p = 0.026).


Results obtained by CT-guided bone biopsy contributed to prompt diagnoses of spinal infections, especially those caused by tuberculosis. Despite administration of anti-tuberculous agents, patients with tuberculous spondylitis showed an increased tendency to undergo late surgery.


The incidence of spinal infection has grown rapidly with increasing uses of invasive spinal procedures and intravascular cathetes that can act as a means of inoculation and spreading of pathogens into the vertebra, intervertebral disks, and adjacent muscles [1]. There is also an upward trend in spinal tuberculosis due to the growing number of immunocompromising conditions [2-5]. Even though the advanced diagnostic technology of magnetic resonance imaging (MRI) has improved the sensitivity and specificity of this disease entity, the diagnosis of spondylitis has been a challenge for physicians for many years [6].
Computed tomography (CT)-guided biopsy is a valuable tool in the diagnosis of musculoskeletal diseases. The value of this procedure in pyogenic spinal infection has been investigated in several studies, indicating a sensitivity range of 30% to 50% [7-9]. However, the diagnostic yield of CT-guided bone biopsy for spinal tuberculosis has rarely been exploited despite the recent rising prevalence of both tuberculous and pyogenic spinal infection [10,11].
To evaluate the roles of CT-guided biopsy in tuberculous and pyogenic spondylitis, we conducted a retrospective cohort study in patients who were diagnosed with spine infection and who received a CT-guided bone biopsy over a 13-year period. Among recipients of CT-guided bone biopsies, we also compared the clinical outcomes between tuberculous and pyogenic spondylitis groups.


Study population and patient selection

This retrospective cohort study was designed to identify the diagnostic yield of CT-guided bone biopsy and to evaluate the clinical outcomes in patients with spinal infection from March 1996 to March 2008 in a 1,900-bed tertiary care university hospital. To search patients who have underwent CT-guided bone biopsy and diagnosed to have osteomyelitis, we screened cases in which “bone” specimen was obtained by “CT-guided procedure.” Specimen code for “bone tissue” and procedure codes for “bone needle biopsy procedure” and “imaging guidance procedure” were used for screening cases. Electronic medical records were reviewed among screened individuals. From the medical records, we selected patients who had cultural and pathologic reports and radiologic findings compatible with those of pyogenic and tuberculous spondylitis. Based on histopathologic reports, cases proven to have malignancy or non-septic inflammatory discitis were excluded. Finally adults patients, who had underwent CT-guided bone biopsy and been diagnosed to have infectious spondylitis by the evidence of cultural, pathologic, and radiological data and been treated with prolonged antimicrobial therapy, were enrolled in the study.

Definitions and data collection

Patients with tuberculous spondylitis were categorized into definite, probable and possible groups, whereas those with pyogenic one were categorized into definite and possible. The definite group referred to cases with microbiologic evidence of bacteria, fungus or tuberculosis. The presence of caseating granulomatosis or acid-fast bacilli in Ziehl-Neelsen stained slides on histopathology defined probable tuberculosis in cases without mycobacterial growing. Detection of tuberculosis by polymerase chain reaction (PCR) was also used to aid the probable diagnosis when microbiologic evidence was not given [12]. The possible group contained cases that were clinically diagnosed and treated with conventional antibacterial and anti-tuberculous agents by attending physicians, based on clinical presentation and manifestation when test results from cultures, histopathology, and tuberculosis PCR failed to prove presumptive pathogen. Radiologic findings such as the patterns of destruction of vertebral end plates and signal-intensity changes of involved vertebrae, and presence of epidural, paravertebral, and dis-space abscess were also used to support a clinical diagnosis.
The following patient data were collected using electronic medical and laboratory records: initial clinical presentation such as fever, constitutional symptoms, and back pain; underlying comorbidity; laboratory data including white blood cell count (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level; involved vertebra; radiologic findings suggesting tuberculosis or pyogenic spinal infections, the presence of paravertebral or epidural abscess; results of histopathology; antibiotic regimen and duration of treatment; and performance of surgical intervention
Clinical improvement was assessed at 4 weeks during the course of therapy. Lack of improvement referred to the cases with persistent or aggravated back pain, necessity of abscess drainage, or development of neurologic deficit [13]. The patients were followed up for 6 months after completion of treatment. Clinical success was defined as cases without recurrence at 6 months after finishing treatment, whereas clinical failure was as those with death, relapse or repetitive surgery during the follow-up period.
The time of surgery was defined as days between the date of CT-guided bone biopsies and the date of surgical intervention. Types of surgical intervention were further classified into early and late surgery. The late cases were designated as those performed 1 month after diagnosis. The number and percentage of late surgeries was also calculated to evaluate the efficacy of initial medical treatment. The decision to perform early or late surgery was made by the attending surgeon. The reasons for late surgical approach were divided into two categories whether it was initially planned at the time of diagnosis when the early surgery was indicated or it was abruptly performed as the results of lack of clinical improvement.

Statistical analysis

Student t test was used to compare continuous variables, and Pearson chi-square test or Fisher exact test was used to compare categorical variable. Values of p < 0.05 were considered statistically significant. SPSS statistics for Windows, PASW version 17.0 (SPSS Inc., Chicago, IL, USA), was used for all statistical analyses.


Diagnostic yield of CT-guided bone biopsy

During the study period between 1996 and 2008, a total of 1,027 cases were screened to have had undergone CT-guided bone biopsy. Of them, 927 were excluded; 898 malignancy and non-septic discitis; 29 incomplete medical records. Only one hundred patients have been diagnosed and treated as infectious spondylitis among recipients of CT-guided bone biopsy over the 13 year-study period.
Of 100 patients, 67 were identified to have pyogenic spondylitis. Definite diagnosis for pyogenic spondylitis were made in 36 patients because bacterial and fungal growing was confirmed in those (32 and 4), whereas possible diagnosis were made in 31 patients who had been treated with antibacterial agents based on clinical and laboratory supports without microbiologic evidence. Thirty-three patients were diagnosed to have tuberculous spondylitis. Definite growth of Mycobacterium tuberculosis was confirmed in 13 patients. Histopathological analyses of vertebral marrow showed granuloma with caseating necrosis in nine patients, suggesting probable tuberculosis. Eleven patients were treated with antituberculous agents based on clinical diagnosis and referred to possible group.
Microbiologic and pathologic yield of CT-guided bone biopsy for diagnosing definite and probable infectious spondylitis was shown in Table 1. In pyogenic spondylitis group, of 36 confirmed cases, 22 micro-organisms were recovered from bone specimens obtained by biopsies and remaining 14 organisms were from blood and other tissues, which were not obtained from CT-guided biopsy. This resulted in 33% of diagnostic yield of CT-guided bone biopsy for pyogenic spondylitis. Definite growth of M. tuberculosis in 13 patients was identified respectively from 11 bone specimens and two sputum cultures. Nine pathologic results from bone marrows had assisted to make a diagnosis for probable tuberculous spondylitis. Among a total of 33 tuberculosis cases, 20 were identified by test results from bone specimens, which had yielded 61% of diagnosis of tuberculosis.

Clinical characteristics of tuberculous and pyogenic groups

Clinical characteristics of patients with tuberculous and pyogenic spondylitis are compared in Table 2. The median age was 56 years and males were predominant in the pyogenic group (68.7%) compared with the tuberculous group (45.5%, p = 0.044). Patients presented with spinal disease (26%), diabetes (13%), and hypertension (13%). The most commonly involved vertebrae were lumbar (56%), followed by thoracic (19%) and thoracolumbar (9%). Cervical thoracolumbar vertebrae were more commonly involved in the tuberculous group (51.5%) than in the pyogenic group (17.9%), with statistical significance (p = 0.002). More than three ranges of spines were extensively involved in only in one case, which was caused by Pseudomonas aeruginosa. An abscess in the psoas muscles or in the epidural or paravertebral space was observed in 49% of patients. Patients with pyogenic spondylitis more frequently presented with fever accompanied by an increase in inflammatory markers than did those with tuberculosis. A total of 11 cases were identified to have surcgical site infection which occurred within 3 months after spine surgery in pyogenic spondylitis group.
Surgical intervention was performed in 46% of spondylitis cases. Sixteen patients (16%) underwent surgery 1 month after diagnosis despite medical treatment: these included nine cases of tuberculous spondylitis and seven cases of pyogenic one (56.3% vs. 23.3%, p = 0.026). There were no differences between the two groups with respect to rates of 30-day mortality and repetitive surgery. Patients with pyogenic spondylitis had stayed longer in hospital than had those with tuberculous spondylitis (38 days vs. 21 days, p = 0.003).

Microbiological data

Thirty-eight isolates were recovered in 36 patients of definite pyogenic groups. Mixed organisms were found in two patients with methicillin-susceptible Staphylococcus aureus and Streptococcus viridans and methicillin-resistant S. aureus and Enterococcus faecalis. S. aureus was the most commonly recovered isolate, accounting for 47% of cases with definite pyogenic spondylitis. Gram-negative organisms were cultivated in eight patients (21%). Fungus was recovered in four patients (11%), and all of these cases were related to surgical site infection. Detailed microbiological results are provided in Table 3.

Comparison between culture-positive and negative groups with bacterial infection

Characteristics of patients with positive culture results in definite bacterial infection group were compared with those who had negative culture results in possible group (Table 4). Four fungal cases were excluded in this analysis. The rates of prior antimicrobial treatment were not different between the two groups. An increase in inflammatory markers was observed in the culture-positive group, in particular the WBC and CRP levels. Clinical outcomes were not different between the two groups.

Late surgical intervention

A late surgical approach was attempted in 16 patients with nine cases of tuberculosis and seven cases of pyogenic spondylitis, including probable and possible diagnoses (Table 5). Five patients with spinal tuberculosis had accompanying pulmonary infection. When we analysed the reasons for late surgery, most cases were related to lack of clinical improvement related to aggravation of back pain, progression of abscess and neurologic deficit. In four tuberculous spondylitis cases, delayed surgery was planned intentionally at the time of diagnosis even though patients presented with epidural and paravertebral abscesses. In these cases, attending physicians have decided to observe the response of antituberculosis treatment and delay the surgery for at least 1 month, expecting the improvement of spondylitis by medical therapy. The size of the abscess in four patients, at the time of assessment of clinical response, was not improved despite antituberculous therapy, which had resulted in the late surgery.


This study evaluated the diagnostic yield of CT-guided bone biopsy for infectious spondylitis in a country with a high prevalence of tuberculosis. Microbiological and pathologic data obtained by CT-guided bone biopsy contributed to the prompt diagnosis of spinal infection, especially in cases with tuberculosis, which showed a 60% diagnostic yield. The value of percutaneous biopsy had been analysed in previous studies with yields ranging from 40% to 70% [7,10,11,14]. The 60% yield of CT-guided bone biopsy in diagnosing tuberculous spondylitis achieved in this study is in accordance with results from previous studies. Even though prior studies have already reported the high yield of percutaneous biopsy for the diagnosis of tuberculosis, these studies did not target subjects who underwent CT-guided bone biopsy. Most of the research issues associated with spinal tuberculosis have been confined to the diagnostic modality of MRI and clinical outcomes [2,6,15]. In such a situation lacking the evidence provided by specimens obtained under the guidance of CT, our study has significance in having evaluated a large number of patients and provided a comprehensive conclusion.
The utility of inflammatory markers for the differentiation between tuberculous and bacterial etiology was previously investigated in community-acquired pneumonia. A marked increase in inflammatory markers was strongly associated with a bacterial etiology and disease severity in pneumonia [16,17]. Comparative studies of pyogenic and tuberculous spinal infections have investigated the association between an increased ESR and pyogenic spondylitis, but the results were not sufficiently consistent to show a significant association [11,18]. The results of the present study showing a strong association between inflammatory markers and pyogenic spondylitis are expected to be valuable in discriminating the bacteria from tuberculosis.
The culture-negative rate was approximately 50% for all of bacterial spondylitis cases in this study. To identify factors associated with culture-negative results, we compared the culture-positive and -negative groups. Patients in the culture-negative group presented with a lower CRP and a lower ESR compared with those of the culture-positive group, and previous antimicrobial therapy did not affect the negative results. In the previous study of evaluating the impact of prior antibiotic exposure on the results of culture in patients with infectious spondylitis, the presence of paravertebral abscess, elevated WBC, CRP levels were related to positive outcome, whereas longer duration of previous antibiotic exposure, 4 or more days was related to negative outcome [19]. According to the results of this study, although we have investigated duration of previous antibiotic exposure, we couldn’t find the exact data for duration of antibiotic exposure. These findings might reflect the fact that this study was conducted in a tertiary-care hospital to which most of the patients were referred during antimicrobial therapy, and data concerning prescriptions given outside of the hospital may be incorrect. Alternatively, the negative culture result might be a reflection of a less extensive inflammatory process triggered by a low grade infection [20]. It is also possible that samples were collected at the site devoid of organisms, resulting in a false-negative result [21]. Given the concerns surrounding a possible false-negative result, a repeat biopsy might be considered when the first biopsy is negative.
In past decades, radical resection of the tuberculosis-infected focus and bone grafting was suggested as a general approach for the treatment of spinal tuberculosis in patients with severe neurological deficits. With the advent of imaging modalities and effective treatment regimens, a non-operative approach was subsequently introduced for those with spinal tuberculosis and neurologic deficits [22]. However, delayed surgery for late onset complications involves the risk of neural deterioration and vertebral destruction leading to severe kyphosis [23]. In our study, 16 patients underwent delayed operation after the lack of improvement by medical approaches; of these, late surgery had been originally planned for four cases. Upon further investigation into these cases of late surgery for spinal tuberculosis, disease progression including kyphosis and spinal instability was observed in a total of nine cases despite administration of more effective antituberculous agents. These deteriorating outcomes in cases of delayed surgery raise concerns regarding trials that delay the initial surgical approach indicated at the time of diagnosis. According to a study that evaluated prognostic factors influencing the outcomes of patients with spinal tuberculosis, radical surgery was significantly related to a favourable outcome and a large number of involved vertebrae was related to the progression of kyphosis [2,24]. Considering these outcomes of surgical treatment in spinal tuberculosis, it is important to cautiously select cases that are predicted to deteriorate during medical treatment for early-radical operation, especially those involving more than two vertebrae and with expected kyphosis [2,24]. If it is not possible to undergo an early-radical approach in adversely predicted cases, it is mandatory to perform short-term follow-up for early recognition of impending neurologic deficits.
This study has several limitations. First, it was a retrospective design with a small sample size that was not sufficient to show statistical power. Because clinical data regarding initial presentations and outcomes were collected retrospectively, initial clinical presentation and additional data that could be helpful to assess possible portals of entry in patients with spondylitis were not described precisely. A second limitation concerns the problems associated with a large single center study in a tertiary to which most of the patients were referred from other institutions. This might result in an inaccurate assessment of previous antimicrobial usage outside of this hospital and may lead to a large number of negative-cultural reports; thus, underestimating the exact diagnostic yield of bone biopsy in pyogenic spondylitis. Finally, there is the possibility of inaccurate diagnoses in cases of possible spondylitis. Among antituberculous agents, rifampin, and fluoroquinolone are known to be active against staphylococcal infection. Many cases that were treated as possible tuberculosis might have been culture-negative pyogenic spondylitis. To adjust for possible misdiagnoses between tuberculosis and bacterial etiologies, we classified cases into definite, probable, and possible groups. The clinical characteristics of tuberculous and pyogenic spondylitis infections showed consistent results even after adjusting for possible cases.
In conclusion, microbiological and pathologic data obtained by CT-guided bone biopsy contributed to a prompt diagnosis of spinal infection, especially the 60% diagnostic yield caused by tuberculosis. Pyogenic spondylitis was associated with fever more frequently than was tuberculous spondylitis. Despite early administration of antituberculous agents, patients with tuberculosis tended to show progression of inflammatory and destructive processes, leading to late surgical intervention. With the current increasing prevalence of both tuberculous and pyogenic spinal infections, CT-guided bone biopsy is expected to serve as an effective modality for the prompt diagnosis and proper management of infectious spondylitis.


1. Microbiological and pathologic data obtained by computed tomography (CT)-guided bone biopsy contributed to an effective diagnosis of spinal infection, especially the 60% diagnostic yield caused by tuberculosis.
2. Despite early administration of anti-tuberculous agents, patients with tuberculosis tended to show progression of inf lammatory and destructive processes, leading to late surgical intervention.
3. CT-guided bone biopsy is expected to serve as an effective modality for the prompt diagnosis and proper management of infectious spondylitis.

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Table 1.
Microbiologic and pathologic yield of computed tomography-guided bone biopsy
Infectious spondylitis Total no. (%) (n = 100) No. of cases (%)
Pyogenic spondylitis (n = 67) Tuberculous spondylitis (n = 33)
Definite and probable cases 58 (58) 36 (54) 22 (67)
Proven by bone tissue obtained from CT-guided bone biopsy 42 (42) 22 (33) 20 (61)
Proven by other tissues not obtained from CT-guided biopsy 16 (16) 14 (21) 2 (6)

CT, computed tomography.

Table 2.
Clinical characteristics in groups of pyogenic and tuberculous spondylitis
Variable No. of cases (%)
Total (n = 100) Pyogenic spondylitis (n = 67) Tuberculous spondylitis (n = 33) p value
Age, yr 56 (43–64) 57 (42–66) 54 (44–4) 0.892
Male sex 61 (61) 46 (68.7) 15 (45.5) 0.044
Fever 46 (46) 35 (52.2) 11 (33.3) 0.038
Underlying disease
 Diabetes 13 (13) 7 (10.4) 6 (18.2) 0.360
 Hypertension 13 (13) 6 (9.0) 7 (21.2) 0.127
 Renal insufficiency 6 (6) 2 (3.0) 4 (12.1) 0.177
 Chronic liver disease 4 (4) 3 (4.5) 1 (3.0) 1.000
 Spinal disease 26 (26) 23 (34.3) 3 (9.1) 0.004
 Others 25 (25) 15 (22.4) 10 (30.3) 0.491
Involved spines 0.002
 Cervical thoracolumbar 29 (29) 12 (17.9) 17 (51.5)
  Cervical 1 (1) 0 1 (3.0)
  Thoracic 19 (19) 8 (11.9) 11 (33.3)
  Thoracolumbar 9 (9) 4 (6.0) 5 (15.2)
 Lumbar-sacral 69 (69) 53 (79.1) 16 (48.5)
  Lumbar 56 (56) 41 (61.2) 15 (45.5)
  Lumbosacral 13 (13) 12 (17.9) 1 (3.0)
 Extensive 2 (2) 2 (3.0) 0
Presence of abscessa 49 (49) 30 (44.8) 19 (57.6) 0.229
Index of inflammation
 WBC, × 1,000 cells/µL 7,760 (6,300–10,020) 8,050 (6,712–10,140) 6,800 (5,670–9,075) 0.016
 ESR, mm/hr 58.00 (28.00–79.00) 64.50 (42.25–88.50) 52.00 (22.00–70.50) 0.038
 CRP, mg/dL 3.43 (0.97–7.61) 4.07 (1.64–9.05) 2.55 (0.71–5.01) 0.179
Surgical intervention 46 (46) 30 (44.8) 16 (48.5)
 Early (within 1 month) 30 (30) 23 (76.7) 7 (43.8)
 Late (after 1 month) 16 (16) 7 (23.3) 9 (56.3) 0.026
30-Day mortality 3 (3) 2 (3.0) 1 (3.0)
Repetitive surgery 1 (1) 0 1 (3.0)
Unknown, follow-up loss 12 (12) 7 (10.4) 5 (15.2)
Hospital stay 32 (19–50) 38 (24–52) 21 (9–35) 0.003

Values are presented as median (interquartile range) or number (%). Characteristics of groups between pyogenic and tuberculous spondylitis were compared in the analysis including definite, probable, and possible cases.

WBC, white blood cell count; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.

a Abscess at psoas muscles, epidural space, and paravertebral area.

Table 3.
Isolated organisms
Isolated organism No. of isolates (%) (n = 38)
Gram-positive organisms 26 (68.4)
Staphylococcus species 21 (55.3)
  Staphylococcus aureus 18 (47.4)
   Methicillin-susceptiblea 17 (44.7)
   Methicillin-resistantb 1 (2.6)
  Coagulase-negative staphylococcus 3 (7.9)
   Methicillin-susceptible 2 (5.3)
   Methicillin-resistant 1 (2.6)
  Streptococcus speciesa 2 (5.3)
  Enterococcus speciesb 2 (5.3)
Gram negative organisms 8 (21.1)
Klebsiella pneumoniae 2 (5.3)
Pseudomonas aeruginosa 2 (5.3)
Escherichia coli 1 (2.6)
Alcaligenes xylosoxidans 1 (2.6)
Burkholderia cepacia 1 (2.6)
Salmonella Paratyphi A 1 (2.6)
Fungus 4 (10.5)
Aspergillus fumigatus 3 (7.9)
Candida albicans 1 (2.6)

a Mixed organisms with methicillin-susceptible S. aureus and Streptococcus viridans in one patient.

b Mixed organisms with methicillin-resistant S. aureus and Enterococcus faecalis in one patient.

Table 4.
Clinical characteristics in patients with culture-positive and negative results in bacterial infection group
Variable No. of patients
p value
Culture-positive (n = 32) Culture-negative (n = 31)
Age, yr 57 (42–69) 55 (40–62) 0.487
Male sex 23 (71.9) 19 (61.3) 0.373
Underlying disease 24 (75.0) 18 (58.1) 0.154
Previous antibiotic-usage 21 (65.6) 14 (45.2) 0.102
Fever 12 (37.5) 13 (41.9) 0.719
Index of inflammation 32 30
 WBC, × 1,000 cells/µL 8,290 (6,640–14,930) 7,990 (6,700–9,360) 0.011
 ESR, mm/hr 66.5 (52.8–98.8) 61.0 (31.8–84.8) 0.075
 CRP, mg/dL 6.95 (3.37–13.63) 2.30 (0.68–4.24) < 0.001
Surgical intervention 16 (50.0) 11 (35.5) 0.244
Clinical improvementa 28 (87.5) 27 (87.1) 0.263
Hospital stay 42 (28–55) 31 (35–50) 0.064

Values are presented as median (interquartile range) or number (%). Characteristics between patients with definite and possible bacterial infections were compared. Four fungal cases were not introduced in this analysis.

WBC, white blood cell count; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.

a Assessment at at 4 weeks during the course of therapy.

Table 5.
Late surgical attempts in 16 patients
No. Age Sex Clinical diagnosis Comorbidity Time of surgery Abscess Reasons for late surgery Level Treatment regimen Duration, mon
1 52 F Tuberculous, possible Pulmonary TB 72 Yes Delayed surgery T6-8 HREZ 18
2 50 F Tuberculous, probable No 71 Yes Progression of abscess L3-4 HREZ 17
3 73 M Tuberculous, possible HTN 54 Yes Progression of abscess T10-11 HREZ 10
4 21 M Pyogenic, definite No 126 No Neurologic deficit L4-5 PIP/TAZ, CFTZ, SMX/TMP 6
5 43 M Tuberculous, definite Pulmonary TB 38 Yes Progression of abscess T10-12 HREZ 18
6 61 F Tuberculous, definite Pulmonary TB 56 No Delayed surgery L2-3 HREZ 14
7 54 M Pyogenic, possible HIVD 48 Yes Aggravation of back pain L4-5 CFZ, CIP, CLND 2.5
8 47 F Tuberculous, probable Pulmonary TB 55 Yes Delayed surgery T12-L1 HREZ 15
9 54 M Pyogenic, definite HIVD 195 Yes Relapsed infection L4-5 Fluconazole 2
10 44 M Tuberculous, probable HIVD 306 No Neurologic deficit L2-3 HREZ 12
11 22 F Tuberculous, probable Pulmonary TB 50 Yes Progression of abscess L1-2 HREZ 14
12 25 M Pyogenic, possible HIVD 67 No Neurologic deficit L3-4 CFZ→CIP, CLND 2
13 60 F Pyogenic, possible Behcet 81 Yes Progression of abscess L5 CFZ→CIP, RFP 12
14 78 F Pyogenic, possible HTN 59 No New abscess formation L3-S CTRX, VANC→LFLX, RFP 4
15 69 M Pyogenic, definite LC, CRF 61 Yes Progression of abscess T11-12 MERO 2.5
16 57 F Tuberculous, definite HIVD 102 Yes Delayed surgery C6-T3 HREZ 15

TB, tuberculosis; HREZ, isoniazid + rifampicin + ethambutol + pyrazinamide; HTN, hypertension; PIP/TAZ, piperacillin/tazobactam; CFTZ, ceftazidime; SMX/TMP, sufamethoxazole/trimethoprim; HIVD, herniated intervertebral disc; CFZ, cefazolin; CIP, ciprofloxacin; CLND, clindamycin; RFP, rifampicin; CTRX, ceftriaxone; VANC, vancomycin; LFLX, levofloxacin; LC, liver cirrhosis; CRF, chronic renal failure; MERO, meropenem.


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