INTRODUCTION
Anaphylaxis is a serious systemic hypersensitivity reaction that can lead to sudden death [
1]. Previous studies have reported that the annual prevalence of anaphylaxis was 0.01% to 0.03% and has been growing [
2,
3]. Despite the clinical importance of anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis and its risk factors remain poorly described [
4]. Limited evidence suggests that the location of residence is associated with the incidence of anaphylaxis and epinephrine auto-injector (EAI) prescription rates [
5,
6]. While Sheikh and Alves [
5] reported that there were more admissions for anaphylaxis in rural areas of England, Mullins et al. [
6] showed that there were more EAIs sold in urban areas of Australia.
Epinephrine is the most important cure for anaphylaxis [
7,
8]. Rapid administration of epinephrine for patients with anaphylaxis is very important, as delayed administration is associated with a poor prognosis [
9]. EAI is a syringe containing epinephrine and that can be immediately self-injected by patients at the occurrence of anaphylaxis, and is currently the most recommended anaphylaxis treatment for patients [
10]. If there are regional variations in the prevalence of anaphylaxis and EAI prescription, different programs to prevent anaphylaxis are needed according to these different regional environments. However, there have been no epidemiologic studies evaluating the prevalence of anaphylaxis and EAI prescription rates by region.
This study was conducted in order to investigate whether there are regional differences in the occurrence of anaphylaxis and EAI prescription rates. We investigated the prevalence of anaphylaxis and EAI prescription rates among patients with anaphylaxis in urban and rural areas of Korea using the nationwide claim database.
RESULTS
The prevalence of anaphylaxis over 5 years was 0.023%, with the annual prevalence increasing every year (
Fig. 1). Anaphylaxis prevalence was the highest at the ages of 50 to 59, and anaphylaxis was 1.2 times higher in males than in females (54% vs. 46%) (
Table 1). However, at ages 70 and older, anaphylaxis was more common among females.
By region, the prevalence of anaphylaxis in rural areas was 1.7 times higher than in urban areas (17.3 vs. 28.8/100,000 person-year). The prevalence of anaphylaxis increased from 0.014% to 0.022% (57.1% increase) in urban areas and from 0.023% to 0.040% (74.0% increase) in rural areas over the 5-year period (
Fig. 1). The top five areas with the highest prevalence of anaphylaxis all belonged to rural areas. Gangwon province showed the highest prevalence of anaphylaxis, which was 4.0 times higher prevalence than that of the area with the lowest prevalence (
Table 2,
Fig. 2). The prevalence of anaphylaxis increased over 5 years in almost all regions (
Fig. 2,
Supplementary Fig. 1).
The EAI prescription rate for anaphylaxis was 6.2% in Korea. The EAI prescription rate increased from 3.7% to 7.6% over the 5-year period, a 2.0-fold increase. The EAI prescription rate increased from 7.8% to 15.0% (1.9 times increase) in urban areas and from 1.4% to 3.9% (2.8 times increase) in rural areas over the 5-year period (
Fig. 3). The EAI prescription rate among patients with anaphylaxis was 3.9 times higher in urban areas than in rural area (12.0% vs. 3.1%) (
Table 2). Regional analysis between the capital and non-capital areas showed similar results when comparing between rural and urban areas. Non-capital areas had a relatively high prevalence of anaphylaxis and a low EAI prescription rate (
Supplementary Table 1). The EAI prescription rate was higher in urban areas, including Seoul, which is Korea’s capital city. The EAI prescription rate in the Gangwon province, which showed the highest prevalence of anaphylaxis, was one-fifth of the prescription rate of Seoul (
Table 2,
Fig. 2). There were higher prevalences of anaphylaxis and lower EAI prescription rates in rural areas than in urban areas (
p < 0.001). There was a moderate positive linear relationship between EAI prescription rates and the number of doctors per population (r = 0.623,
p < 0.001) (
Supplementary Fig. 2).
DISCUSSION
The overall prevalence of anaphylaxis was 0.023% and the EAI prescription rate was 6.24% over a 5-year period in Korea. The annual prevalence of anaphylaxis and the EAI prescription rate increased over this 5-year period. The prevalence of anaphylaxis in rural areas was 1.7 times higher than that in urban areas, but the EAI prescribing rate for patients with anaphylaxis in rural areas was as low as one-quarter of that in urban areas.
The present study showed that the annual prevalence of anaphylaxis increased over 5 years in both rural and urban areas, but the relative risk of anaphylaxis in rural areas was 1.66 times higher than that in urban areas in Korea. It is not clear whether the higher prevalence of anaphylaxis in rural areas is only found in Korea or not, but a few studies suggest that the location of residence is associated with both the incidence of anaphylaxis and EAI prescription rates [
5,
6]. Sheikh and Alves [
5]. reported that there were regional variations in admissions for anaphylaxis in England and that the relative risk of admissions for anaphylaxis in rural areas was 1.35 times higher than that in urban areas in England. Mullins et al. [
6]. suggested that residence in major cities could be a risk factor for anaphylaxis in Australia based on the higher EIA prescription rates seen in major cities than in rural areas, although they reported that there was no difference in anaphylaxis admissions between rural and urban areas. However, considering the discrepancy between EAI prescription rates and the prevalence of anaphylaxis clearly seen in the current study, the study of Mullins et al. [
6] may suggest that EAI prescription rates in urban areas were much higher than those in rural areas, in spite of the similar risk of anaphylaxis admission in rural and urban areas. By using national claim data, the current study showed regional variations in the prevalence of anaphylaxis clearly comparable with the above-mentioned studies which used data on anaphylaxis admissions, because most anaphylaxis patients would be treated in emergency departments without being admitted. Considering the world-wide increase of anaphylaxis and rapid environmental changes in many countries, it is important to know that specific regional environments could generate an increased risk of anaphylaxis. Investigations on anaphylaxis epidemiology and EAI prescription by regions and planning proper programs are needed in order to prevent and manage anaphylaxis for rural and urban areas.
The reason for the higher prevalence of anaphylaxis in rural area of Korea is unclear. However, it could be postulated that the parameters involved in a regional environment, including age and gender distribution, socio-economic status, and common triggers for anaphylaxis, are closely related with regional culture and life style in rural areas, which is important. In previous studies, infants, teenagers, and the elderly have shown an increased vulnerability to anaphylaxis for different reasons [
1], and the predominant triggers for anaphylaxis are different between different age groups [
1,
7]. Socio-economic status and geographic remoteness have also been suggested as risk factors for anaphylaxis admission [
5,
6]. In actuality, the common causes of anaphylaxis vary according to where the study was conducted. Studies conducted in tertiary hospitals have reported that drugs are the most common trigger, and then food and insect stings are next [
15,
16]. In contrast, studies based on general physicians' medical records reported insect stings as the most common trigger and drugs as the next-most common [
17,
18]. There may be more bees and more chances for insect stings in rural areas.
In contrast with other allergic diseases, anaphylaxis is a life-threatening condition and could happen unexpectedly, and thus some patients under attack of anaphylaxis may die due to a lack of immediate treatments [
19]. EAI is critical for those patients since it is the only available form of treatment for them [
10]. EAI is recommended when anaphylaxis patients who were affected an inevitable cause show respiratory symptoms or severe symptoms such as hypotension [
10]. There have not been many studies on EAI prescription rates. Wood et al. [
20] reported that 40% of patients with multiple episodes of anaphylaxis have a currently available EAI. Clark et al. [
21] reported that EAI was prescribed in 27% of patients with systemic reactions to bee stings at the time of discharge from the emergency room. However, several studies have reported that EAI is under-prescribed [
22]. It is reported that among patients of fatal food anaphylaxis in the United States, only 11% (7/63) had EAI available at the time of fatal reaction [
23]. The prescription rate of EAI in Korea was lower compared with those of previous reports in this study, although it was also rising in recent years. It is partly because the diagnosis of anaphylaxis is not confirmed but based on claim data, which could include suspected and unconfirmed cases of anaphylaxis. However, the percentage of EAI prescription rates against the number of patients with anaphylaxis in urban areas was 12.04%, while it was 3.13% in rural areas in Korea. It is obvious that there is a serious under-prescription of EAI in rural areas, although it is suspected that there are more triggers like bee stings which are difficult to avoid in rural areas.
The finding of the lower EAI prescription rate in rural areas compared with in urban areas in this study is consistent with that of the previous study by Mullins et al. [
6] that reported a higher EAI prescription rate in urban areas and in patients with a superior social economy state in Australia. Simons et al. [
24] reported that the EAI prescription rate was higher in the young population aged < 17 years in Canada. Besides age and socio-economic status distribution in rural areas, regional variations in the medical environment including the number of allergists and accessibility to hospitals may explain the differences in EAI prescription rates. In actuality, the EAI prescription rate showed a moderate positive correlation with the number of doctors per population in the current study. The system that only allows for purchasing EAI through the Korea Orphan & Essential Drug Center could be considered as a cause of the regional imbalance of EAI prescription rates between urban and rural areas. These findings highlight the need for education programs for the general population, patients with anaphylaxis, doctors, and emergency medical workers in rural areas.
There are several limitations to discuss. First, there were no data in this study for evaluating anaphylaxis triggers. Investigating the common triggers in rural and urban areas would be important for evaluating the differences in regional environments related to anaphylaxis. Although epidemiology studies conducted in the community have usually reported insect stings as one of the major causes of anaphylaxis, previous studies in Korea conducted in tertiary hospitals have reported drug and food as the most common causes. Second, there is no validation of the diagnosis of anaphylaxis. Insurance claim data could have many unconfirmed and anaphylaxis-like patients under the diagnosis of anaphylaxis. Also, insect sting-induced anaphylaxis could not be defined because of the absence of an appropriate ICD code. This is a common problem of studies using ICD-10 codes. The data used in this paper also does not include the contents of drugs. So, by analyzing only with the specific diagnostic code, the positive predictive value may be high, but with a low specificity. In order to validate the diagnosis of anaphylaxis, reviews of the medical records and treatments are needed. Third, the area in this study is the location of the hospital where the diagnosis was made; therefore, it is not known whether the patient actually lives in an urban or rural area. However, since anaphylaxis is an urgent event, patients are likely to visit a nearby hospital. Fourth, because the data are based on insurance claim data, the diagnosis of the persons who did not go to the hospital is unknown. Although anaphylaxis is often a self-limiting disease, patients may not go to the hospital, but it is unlikely that the number of such patients would be small because of the high accessibility of medical care in Korea. Finally, it was difficult to confirm the case of recurrence using this data alone.
This study showed regional differences in the prevalence of anaphylaxis and EAI prescription rates in Korea. Rural areas showed a higher prevalence of anaphylaxis and lower EAI prescribing rates than urban areas. Differences in regional environments could not only increase the prevalence of anaphylaxis, but also create an inadequate response to anaphylaxis. The regional differences in the prevalence of anaphylaxis and EAI prescription rates need to be considered in developing anaphylaxis prevention programs and health policies of anaphylaxis. The correlation between the number of doctors per population and the EAI prescription rate showed a moderate positive relationship. This makes sense, as a difference in the number of doctors clearly affects the difference in EAI prescription rates. As a result, efforts will be needed to improve the number of doctors per population in order to reduce the variation in EAI prescription rates by region in the future.