KJIM :: Korean Journal of Internal Medicine

The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics

Bonan Ding, Jiaqi Liu, Igor Lumbeto Tenda Kasay, Nattaya Konsue, Xuan Lin, Fangfang Yan, Dongsheng Wang, Chenghao Lv, Hongjuan Xia, Si Qin

Journal of Ethnopharmacology.2026; 354: 120519. CrossRef

Chaker Ben Salem, Myriam Agrebi, Dhouha Sahnoun, Neila Fathallah, Houssem Hmouda

Advances in the mechanisms of vascular calcification in chronic kidney disease

Journal of Cellular Physiology.2025;[Epub] CrossRef

The Association of Persistent Hyperuricemia With Liver Function and the Management of Uric Acid Levels: Insights From a Three‐Year Prospective Cohort Study

Yina Wang, Minli Qiu, Liuzhong Zhou, Xuqi Zheng, Xinyu Wu, Liudan Tu, Ya Xie, Mingcan Yang, Linkai Fang, Xianghui Wen, Boxiong Jiang, Jieruo Gu

International Journal of Rheumatic Diseases.2025;[Epub] CrossRef

Prediction Trough Concentrations of Valproic Acid Among Chinese Adult Patients with Epilepsy Using Machine Learning Techniques

Nannan Yao, Qiongyue Zhao, Ying Cao, Dongshi Gu, Ning Zhang

Mechanisms Associated With Renal Injury in Hyperuricemia and Strategies for the Development of Natural Active Substances

Wanping Lv, Huixiang Chen, Pan Zhou, Aihua Du, Yu Lei

International Journal of Rheumatic Diseases.2025;[Epub] CrossRef

The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms

Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Zhonghai Li, Gang Xu

Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults

Huakai Wang, Chao Zhang, Yuxin Sun, Sirui Sun, Zhe Wang, Honggang Xiang, Taeyun Kim,

The Relationship Between Uric Acid and Mortality in Hemodialysis Patients

Can Hüzmeli, Ayşe Şeker, Hatice Ortaç, Ali Borazan, Serhan Pişkinpaşa, Ferhan Candan

Hemodialysis International.2025; 29(4): 579. CrossRef

High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes

Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu

Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef

Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study

Xiangyu Chen, Jie Zhang, Feng Lu, Ruying Hu, Xiaofu Du, Chunxiao Xu, Mingbin Liang, Lijin Chen, Weiyuan Yao, Zhimin Ma, Jieming Zhong, Meng Wang

Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study

Balancing Stone Prevention and Kidney Function: A Therapeutic Dilemma

Journal of Clinical Medicine.2025; 14(11): 3678. CrossRef

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of OATF against kidney stones

Sisi Dai, Qi Fang, Hong-Yan Li, Rui Sun, Hui-Yong Zhang, Wei Wu

Dynamic changes in metabolic syndrome components and chronic kidney disease risk: a population-based prospective cohort study

Yue Huang, Rong Fu, Juwei Zhang, Jinsong Zhou, Siting Chen, Zheng Lin, Xiaoxu Xie, Zhijian Hu

Nephrology (Saint-Petersburg).2025; 29(2): 9. CrossRef

The prognostic value of admission serum uric acid for acute kidney injury: a two-center retrospective analysis

Shuo Huang, Linger Tang, Lingyi Xu, Jinwei Wang, Xizi Zheng

Frontiers in Molecular Biosciences.2025;[Epub] CrossRef

Life’s Crucial 9 score and chronic kidney disease: insights from NHANES 2005–2018 and the mediating role of systemic inflammation and oxidative stress

Shiyuan Qin, Jin Yang, Zili Wang, Pinglin He, Taotao Dong, Zhengyun Ren, Qiuyang Li

Clinical observations on arthroscopic removal of urate deposits in the knee: a seven-case series

European Journal of Orthopaedic Surgery & Traumatology.2025;[Epub] CrossRef

Research on related factors of hyperuricemia in high altitude area migrant population

Effect of losartan on uric acid metabolism in children with proteinuric kidney disease: crossover randomized controlled clinical trial

Laura Beaudoin, Luciana Meni Battaglia, Sandra Mariel Martin, Ismael Toledo, Alejandro Balestracci

Identification of the serum uric acid threshold with increasing risk for diabetic nephropathy in type 1 diabetes

Mei Huang, Qianying Wei, Xin Chen, Yao Qin, Liuyan Dai, Yuxiao Li, Yong Gu, Yang Chen, Tao Yang, Mei Zhang

Phenolic acids inhibit local and systemic effects induced by Bothrops brazili venom

Sarah de Sousa Ferreira, Diana Pontes da Silva, Manoela Torres-Rêgo, Allanny Alves Furtado, Eduardo Augusto da Silva Diniz, Karla Patrícia de Oliveira Luna, Arnóbio Antônio da Silva-Júnior, Renata Mendonça Araújo, Marcela Abbott Galvão Ururahy, Davi Serra

Lifestyle factors and hyperuricemia risk: a prospective cohort study of 14,635 participants examining the protective role of daily stair climbing

Wenkui Yin, Donglin Luo, Wenying Huang, Haichao Jiang, Yahai Wang, Haixia Qi

Association Between Serum Uric Acid to Creatinine Ratio and Time in Range in Patients With Type 2 Diabetes

Yu Gong, Ying Li, Qianqian Zhang, Zhangxiang Zhu, Guojuan Wang

Clinical Endocrinology.2025; 103(5): 682. CrossRef

Integrative transcriptomic and metabolomic analysis explores mechanisms by which Astragalus membranaceus and Salvia miltiorrhiza ameliorates hypertensive renal damage

Wenpeng Liu, Cong Han, Wanli Xu, Yanyun Jiang, Yao Liu

Relation of Serum 5‐LOX, Angiotensin Macromolecules, and Some Biochemical Parameters Levels in Renal Failure Patients (ICSEM 2025)

Nephropathogenic infectious bronchitis virus induces epithelial-mesenchymal transition of renal tubular epithelial cells through the TGF-β/p-P38 pathway causing uric acid excretion disorder in chickens

Yunfeng Chen, Yan Shi, Cheng Huang, Haoyu Huang, Yizhou Zeng, Gaofeng Cai, Zhanhong Zheng, Ping Liu, Xiaona Gao, Xiaoquan Guo, Mark T. Heise

Uric acid is negatively associated with cognition in the first- episode of schizophrenia

Acute Renal Failure with Severe Loin Pain and Patchy Renal Ischemia after Anaerobic Exercise in Active Duty Marines

The association between serum uric acid / serum creatinine ratio and in-hospital outcomes in elderly patients with acute myocardial infarction

Lujing Jiang, JunGuo Jin, Xuyu He, Xiangming Hu, Lan Guo, Guo Chen, Yingling Zhou

Uric acid in health and disease: From physiological functions to pathogenic mechanisms

Pharmacology & Therapeutics.2024; 256: 108615. CrossRef

Comparison of the therapeutic effects of febuxostat combined with a low‐purine diet and allopurinol combined with a low‐purine diet on the improvement of gout patients

Xuejiao Chen, Tao Ye, Yuna Dai, Pian Li, Xiaodong Zhao, Yanfang Yu, Xiaoliang Wang, Xiaoya Jiao, Na Shen

International Journal of Rheumatic Diseases.2024;[Epub] CrossRef

Predictive nomogram models for atrial fibrillation in COPD patients: A comprehensive analysis of risk factors and prognosis

Experimental and Therapeutic Medicine.2024;[Epub] CrossRef

Impact of Hyperuricemia and Urate-Lowering Agents on Cardiovascular Diseases

Franklin Sosa, Mohammed Shaban, Jose Lopez, Gustavo J. Duarte, Swati Jain, Asma Khizar, Timothy Vittorio, Rishabh Mishra, Miguel Rodriguez Guerra

Clinical Medicine Insights: Cardiology.2024;[Epub] CrossRef

Effects of a Leucaena leucocephala leaf extract on xanthine oxidase activity and serum oxypurine levels in mice

Flavio Martinez-Morales, Juan R. Zapata-Morales, Juan F. López-Rodríguez, Othir G. Galicia-Cruz, Mario A. Isiordia-Espinoza, Othoniel Hugo Aragon-Martinez

Combination Treatment with Verinurad and Allopurinol in CKD

Hiddo J.L. Heerspink, Austin G. Stack, Robert Terkeltaub, Niels Jongs, Lesley A. Inker, Magnus Bjursell, Noha Maklad, Shira Perl, Olof Eklund, Tord Rikte, C. David Sjöström, Vlado Perkovic

Journal of the American Society of Nephrology.2024; 35(5): 594. CrossRef

Renal interstitial fibrotic assessment using non-Gaussian diffusion kurtosis imaging in a rat model of hyperuricemia

Ping-Kang Chen, Zhong-Yuan Cheng, Ya-Lin Wang, Bao-Jun Xu, Zong-Chao Yu, Zhao-Xia Li, Shang-Ao Gong, Feng-Tao Zhang, Long Qian, Wei Cui, You-Zhen Feng, Xiang-Ran Cai

Development of interpretable machine learning models for prediction of acute kidney injury after noncardiac surgery: a retrospective cohort study

Rao Sun, Shiyong Li, Yuna Wei, Liu Hu, Qiaoqiao Xu, Gaofeng Zhan, Xu Yan, Yuqin He, Yao Wang, Xinhua Li, Ailin Luo, Zhiqiang Zhou

International Journal of Surgery.2024; 110(5): 2950. CrossRef

Association between oxidative balance score and serum uric acid and hyperuricemia: a population-based study from the NHANES (2011–2018)

Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016–2018)

Jinyoung Kim, Da Young Jung, Jin-Hee Lee, Mee Kyoung Kim, Hyuk-Sang Kwon, Hyeon Woo Yim, Su-Jin Moon

Mechanism and use strategy of uric acid-lowering drugs on coronary heart disease

Ruida Cai, Fei Li, Yinhao Li, Yue Li, Wei Peng, Menghui Zhao, Mengjun Wang, Quanyou Long, MengYa Zhu, Xiaolin Chen, Bing Liu, Zhen-gang Tang, Yan Zhang, Xiang Liu, Feifeng Li, Qiong Zhang

IJC Heart & Vasculature.2024; 53: 101434. CrossRef

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Akihiro Hirashiki, Atsuya Shimizu, Takahiro Kamihara, Manabu Kokubo, Kakeru Hashimoto, Ikue Ueda, Toyoaki Murohara

Journal of Cardiovascular Development and Disease.2024; 11(6): 165. CrossRef

Hyperuricemia – consequences of not initiating therapy. Benefits and drawbacks of treatment

Igor Domański, Aleksandra Kozieł, Natalia Kuderska, Paulina Wójcik, Tomasz Dudzik, Łucja Dudzik

Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy

Huiyan Sun, Xinxia Wang, Yongqiang Li, Yingzhi Shen, Lin Zhang, Yingjie Xu, Junling Liu, Xuemei Fan

The effect of hyperuricemia and its interaction with hypertension towards chronic kidney disease in patients with type 2 diabetes: evidence from a cross- sectional study in Eastern China

Xiang-yu Chen, Feng Lu, Jie Zhang, Chun-xiao Xu, Xiao-fu Du, Ming-bin Liang, Li-jin Chen, Jie-ming Zhong

An Updated Review For Hyperuricemia and Gout Management; Special Focus on the Available Drug Delivery Systems and Clinical Trials

Ioannis D. Karantas, Androulla N. Miliotou, Panoraia I. Siafaka

Current Medicinal Chemistry.2024; 31(36): 5856. CrossRef

Causal relationship between uric acid and stroke: a two-sample mendelian randomization study

Multifunctional CeO2:Fe3+ electrodes: Superior uric acid sensing and high-efficiency supercapacitor application

Nandini Robin Nadar, J. Deepak, S.C. Sharma, B.R. Radha Krushna, I.S. Pruthviraj, Rev. Shivaraj Maidur, Chitathoor Sridhar, Subashree Ray, R. Sudarmani, R. Ravi Kumar, H. Nagabhushana

Inorganic Chemistry Communications.2024; 170: 113449. CrossRef

Sensitive and selective non-enzymatic rGO/ZIF-8 hybrid composite-based electrochemical sensor for uric acid detection: Optimisation by response surface methodology

Anis Afiqah Suratman, Aida Zafierah Che Zakaria, Siti Fatimah Nur Abdul Aziz, Shahrul Ainliah Alang Ahmad

Evaluation of Dactylopius opuntiae Extract for Xanthine Oxidase Inhibition and Serum Uric Acid Reduction in a Hyperuricemic Mouse Model

Othoniel H. Aragon-Martinez, Marco M. González-Chávez, Othir G. Galicia-Cruz, Santiago de J. Méndez-Gallegos, Mario A. Isiordia-Espinoza, Flavio Martinez-Morales

Evaluation of renal oxygenation and perfusion in patients with chronic kidney disease: a preliminary prospective study based on functional magnetic resonance

Xinyue Zhang, Chaoyang Ye, Fang Lu, Jing Yang, Yizeng Xu, Chen Wang

Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease Cross Talk

Jacob Nysather, Eda Kaya, Paul Manka, Prakash Gudsoorkar, Wing-Kin Syn

Advances in Kidney Disease and Health.2023; 30(4): 315. CrossRef

Risk factors and management of hyperuricemia after renal transplantation

A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of Cichorium intybus L. Formula in the Improvement of Hyperuricemic Nephropathy in Rats

Mukaram Amatjan, Na Li, Pengke He, Boheng Zhang, Xianyan Mai, Qianle Jiang, Haochen Xie, Xiaoni Shao

Drug Design, Development and Therapy.2023; Volume 17: 107. CrossRef

Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway

Bowei Yang, Guang Wang, Yuhang Li, Tongxin Yang, Haixiang Guo, Pei Li, Jiongming Li

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones

Haizhao Liu, Min Cao, Yutong Jin, Beitian Jia, Liming Wang, Mengxue Dong, Lu Han, Joseph Abankwah, Jianwei Liu, Tao Zhou, Baogui Chen, Yiyang Wang, Yuhong Bian

Clinical significance of hypouricemia in children and adolescents

Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential

Arrigo F. G. Cicero, Federica Fogacci, Valentina Di Micoli, Cristina Angeloni, Marina Giovannini, Claudio Borghi

International Journal of Molecular Sciences.2023; 24(8): 7027. CrossRef

Association and Interaction between Heavy Metals and Hyperuricemia in a Taiwanese Population

Lu-Heng Lu, Chun-Chi Tsai, Chih-Yi Lin, Chih-Wen Wang, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang

Association of serum uric acid with risk of stroke in US adults: A cross-sectional study from NHANES 1999–2020

Bei Gao, Yun Bao, Min Meng, Lijun Yu, Yali Lu, Rina Sa, Xiaoyan Liang, Jie Shi

Journal of Stroke and Cerebrovascular Diseases.2023; 32(8): 107206. CrossRef

Serum uric acid to high-density lipoprotein cholesterol ratio is a promising marker for identifying metabolic syndrome in nondiabetic Chinese men

Xinwen Yu, Fei Sun, Jie Ming, Shengru Liang, Wencheng Zhang, Li Wang, Qiaoyue Li, Qian Xu, Li Wang, Lei Shi, Bin Gao, Qiuhe Ji

Network Pharmacology-Based Approach to Explore the Total Flavonoids of Phellinus igniarius against Hyperuricemia via Regulating the Nrf2/HO-1-ROS-ER Signaling Pathway

Mengling Lv, Zhouqin Liu, Yuling Tao, Chenlei Jiang, Hong Lu, Adadi Parise

Journal of Food Biochemistry.2023; 2023: 1. CrossRef

Serum Uric Acid Levels and Their Association with Renal Function Decline and Kidney Disease Progression in Middle-Aged and Elderly Populations: A Retrospective Cohort Study

Yingxian Luo, Qiong Wu, Runtang Meng, Fuzhi Lian, Chen Jiang, Meiyu Hu, Yaxin Wang, Haiyan Ma

Journal of Multidisciplinary Healthcare.2023; Volume 16: 3357. CrossRef

Recurrent exercise-induced acute kidney injury associated with hypouricemia: a case report and literature review

Jie Zhou, Min Zhang, Qionghong Xie, Ningxin Xu, Mingxin Li, Ming Zhang, Chuanming Hao

Optimal uric acid levels by febuxostat treatment and cerebral, cardiorenovascular risks: post hoc analysis of a randomized controlled trial

Sunao Kojima, Kazuaki Uchiyama, Naoto Yokota, Eiichi Tokutake, Yutaka Wakasa, Shinya Hiramitsu, Masako Waki, Hideaki Jinnouchi, Hirokazu Kakuda, Takahiro Hayashi, Naoki Kawai, Masahiro Sugawara, Hisao Mori, Kenichi Tsujita, Kunihiko Matsui, Ichiro Hisatom

O. B. Shvabskaia, O. V. Izmailova, N. S. Karamnova, O. M. Drapkina

Rational Pharmacotherapy in Cardiology.2022; 17(6): 889. CrossRef

Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment

Mihai-Emil Gherghina, Ileana Peride, Mirela Tiglis, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherita

International Journal of Molecular Sciences.2022; 23(6): 3188. CrossRef

Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study

Yuanyu Chen, Yongzhong Yang, Ziwei Zheng, Hui Wang, Xuelin Wang, Zhikang Si, Rui Meng, Guoli Wang, Jianhui Wu

Hypouricemic effect of gallic acid, a bioactive compound fromSonneratia apetalaleaves and branches, on hyperuricemic mice

Linyun Jiang, Yulin Wu, Chang Qu, Yinsi Lin, Xiaoqing Yi, Changjun Gao, Jian Cai, Ziren Su, Huifang Zeng

Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey

Huijing He, Li Pan, Dingming Wang, Feng Liu, Jianwei Du, Lize Pa, Xianghua Wang, Ze Cui, Xiaolan Ren, Hailing Wang, Xia Peng, Jingbo Zhao, Guangliang Shan

Asymptomatic bacteriuria in candidates for active treatment of renal stones: results from an international multicentric study on more than 2600 patients

T. Calcagnile, M. C. Sighinolfi, B. Rocco, S. Assumma, S. Di Bari, E. Panio, A. Pescuma, M. Ticonosco, G. Tosi, P. Oltolina, S. Resca, S. Kaleci, R. Galli, P. Curti, L. Schips, P. Ditonno, L. Villa, S. Ferretti, F. Bergamaschi, G. Bozzini, A. Eissa, A. Zo

Effect of Selenium Supplementation on Lipid Profile, Anemia, and Inflammation Indices in Hemodialysis Patients

Samaneh Assarzadeh, Sahar Vahdat, Shiva Seirafian, Morteza Pourfarzam, Shirinsadat Badri

Journal of Research in Pharmacy Practice.2022; 11(3): 103. CrossRef

Research Progress on Uric Acid Level and Risk of Death in Maintenance Hemodialysis Patients

Advances in Clinical Medicine.2021; 11(03): 1051. CrossRef

Correlation analysis of low-level serum uric acid and cardiovascular events in patients on peritoneal dialysis

Qiuyue Li, Cong Wu, Wenli Kuang, Xiaojiang Zhan, Jing Zhou

International Urology and Nephrology.2021; 53(11): 2399. CrossRef

Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients

Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh

The Korean Journal of Internal Medicine.2021; 36(4): 767. CrossRef

How important is dietary management in chronic kidney disease progression? A role for low protein diets

The Korean Journal of Internal Medicine.2021; 36(4): 795. CrossRef

J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population

Bon San Koo, Hye-Jin Jeong, Chang-Nam Son, Sang-Hyon Kim, Gheun-Ho Kim, Jae-Bum Jun

Journal of Rheumatic Diseases.2021; 28(4): 225. CrossRef