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Infectious diseases / Original Article
Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19
Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(4):667-675. Published online July 1, 2025
Background/Aims: Post-acute sequelae of COVID-19 (PASC) are highly heterogeneous; therefore, the pathophysiological mechanisms for PASC remain unclear. In this study, we aimed to examine the immunologic aspects of various PASC symptoms.
Methods: We prospectively enrolled adults aged ≥ 18 years wh..
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Hemato-oncology / Original Article
Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi
Korean J Intern Med. 2025;40(4):657-666. Published online July 1, 2025
Background/Aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immu..
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Endocrinology-metabolism / Original Article
Association between body mass index and survival after hematopoietic stem cell transplantation
Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, Seung-Hwan Lee, Gi June Min, Sung-Soo Park, Silvia Park, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Jae-Ho Yoon
Korean J Intern Med. 2025;40(4):645-656. Published online July 1, 2025
Background/Aims: The unclear relationship between body mass index (BMI) and post-hematopoietic stem cell transplantation (HSCT) mortality was investigated, including the impact of metabolic diseases.
Methods: This retrospective study conducted at a Korean tertiary hospital (2009–2021) included patie..
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Pulmonology / Original Article
Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection
Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee
Korean J Intern Med. 2025;40(4):634-644. Published online July 1, 2025
Background/Aims: The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19.
Methods: Using the Korean Natio..
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Pulmonology / Original Article
Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer
Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Min Ki Lee, Insu Kim, Kyung Soo Hong, June Hong Ahn, Jung Seop Eom
Korean J Intern Med. 2025;40(4):626-633. Published online July 1, 2025
Background/Aims: This study investigated the efficacy and safety of first-line afatinib treatment in older patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).
Methods: This retrospective, multicenter, observational cohort study included 103 patients aged..
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Cardiology / Original Article
Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim
Korean J Intern Med. 2025;40(4):616-625. Published online July 1, 2025
Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..
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Gastroenterology / Original Article
Impact of body mass index on clinical outcomes in intestinal Behçet’s disease
Daye Park, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
Korean J Intern Med. 2025;40(4):606-615. Published online July 1, 2025
Background/Aims: The impact of body mass index (BMI) on the clinical outcomes of intestinal Behçet’s disease (BD) remains unclear. This study assessed the association between BMI and disease progression.
Methods: A retrospective analysis of 760 patients with intestinal BD was conducted. Patients were..
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Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
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Gastroenterology / Original Article
Prevalence of cholesterol gallstones in a Korean population over a 14-year period
Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, Tae Young Park, Jae Hyuk Do, Yoo Shin Choi, Seung Eun Lee, Tae Yoon Lee, Hyun Kang, Hyoung-Chul Oh
Korean J Intern Med. 2025;40(4):584-591. Published online June 30, 2025
Background/Aims: The incidence of cholesterol gallstones has increased in the last few decades. This study aimed to evaluate the prevalence of cholesterol gallstones in Korea over a 14-year period, analyze any changes, and identify the predisposing factors.
Methods: A total of 3,909 patients underw..
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Gastroenterology / Original Article
Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim
Korean J Intern Med. 2025;40(4):571-583. Published online July 1, 2025
Background/Aims: The early detection of gastric cancer is crucial for improving patient outcomes. However, its pathogenesis is not fully understood. The microbiome and extracellular vesicles (EVs) might play a role in gastric carcinogenesis. We aimed to identify gastric-carcinogenesis-associated mic..
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Nephrology / Review
Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review
Hyo Jin Kim, Sang Heon Song
Korean J Intern Med. 2025;40(4):557-570. Published online July 1, 2025
Medium cut-off (MCO) membranes have emerged as a promising innovation in hemodialysis (HD), offering enhanced clearance of large middle-molecules of uremic toxins compared to traditional HD membranes, while maintaining minimal loss of albumin. The introduction of MCO membranes represents a significa..
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Pulmonology / Review
Updates on lung cancer screening for early detection
Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang
Korean J Intern Med. 2025;40(4):546-556. Published online July 1, 2025
This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality s..
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Cardiology / Review
Role of catheter ablation in patients with heart failure and atrial fibrillation
Min-Su Jung, Hyoung-Seob Park
Korean J Intern Med. 2025;40(4):533-545. Published online July 1, 2025
Atrial fibrillation (AF) and heart failure (HF) frequently coexist with other cardiovascular conditions and adversely affect each other. Over the past few decades, there have been therapeutic advances in AF and HF; however, whether rate-control or rhythm-control is the superior approach for these pa..
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Infectious diseases / Editorial
Unraveling the immune responses in long COVID through cytokine profiling
Oh-Hyun Cho
Korean J Intern Med. 2025;40(4):531-532. Published online July 1, 2025
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Cardiology / Editorial
Unexplained syncope: what time-to-diagnosis and risk profiles tell us
Yoon Jung Park
Korean J Intern Med. 2025;40(4):529-530. Published online July 1, 2025
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Rheumatology / Image of interest
Hematologic malignancy detected on sacroiliac magnetic resonance imaging in a patient with inflammatory back pain
Jiwon Yang, Hyoo Jeong Lim, Seul Ki Lee, Seung Min Jung
Korean J Intern Med. 2025;40(3):526-527. Published online March 25, 2025
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Gastroenterology / Image of interest
Unusual polypoid mass in the colon
Seung-Woo Lee, Jong Ok Kim
Korean J Intern Med. 2025;40(3):524-525. Published online February 17, 2025
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Rheumatology / Original Article
Clinical perspective on serum periostin in antineutrophil-cytoplasmic antibody-associated vasculitis
Taejun Yoon, Jiyeol Yoon, Eunhee Ko, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2025;40(3):512-523. Published online April 30, 2025
Background/Aims: This study evaluated the clinical utility of serum periostin measured at diagnosis in reflecting activity at diagnosis and predicting all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
Methods: This study included ..
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Rheumatology / Original Article
Altered polyunsaturated fatty acids and oxylipins profile in Behçet’s disease
Mohamed Kacem Ben-Fradj, Ines Naceur, Emna Talbi, Rahma Wada, Omar Feki, Monia Smiti-Khanfir, Moncef Feki
Korean J Intern Med. 2025;40(3):502-511. Published online February 21, 2025
Background/Aims: Behçet’s disease (BD) is an autoinflammatory disease of unknown etiopathogenesis. Oxylipins i.e., prostaglandins, leukotrienes, lipoxins, resolvins, and protectins are bioactive polyunsaturated fatty acids (PUFAs) derivatives involved in inflammatory response induction and resolu..
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Allergy / Original Article
Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting β2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial
Sang Pyo Lee, Sang Min Lee, Sung-Yoon Kang
Korean J Intern Med. 2025;40(3):491-501. Published online April 30, 2025
Background/Aims: Asthma is characterized by chronic inflammation. Inhaled corticosteroids (ICS) remain the cornerstone of anti-inflammatory therapy, targeting both the large and small airways.
Methods: This randomized open-label crossover trial included 30 patients receiving step 3 inhaled medicati..
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