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ORIGINAL ARTICLES 2016 February 15
Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma
KEY MESSAGE
1. Combining radiofrequency ablation (RFA) with transarterial chemoembolization (TACE) to treat hepatocellular carcinoma may have a synergistic effect.
2. In this study, the treatment efficacy and safety of combination treatment was better than RFA or TACE monotherapy.
3. TACE + RFA combination treatment should be considered in suitable early-stage hepatocellular carcinoma patients.
ORIGINAL ARTICLES 2016 February 11
Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
KEY MESSAGE
1. Second primary cancers (SPC) were found in 6.6% of squamous esophageal cancer (EC) patients at initial staging work-ups; therefore, physicians should be aware of the co-existence of SPC with squamous EC.
2. Complementary staging with positron emission tomography-computed tomography (PET-CT) plays a substantial role in the detection of synchronous SPC that were missed on conventional CT.
3. EC patients with SPC had poor survival due to the challenges in providing stage-appropriate treatment.
ORIGINAL ARTICLES 2016 February 26
Effects of bispectral index monitoring as an adjunct to nurse-administered propofol combined sedation during colonoscopy: a randomized clinical trial
KEY MESSAGE
1. The bispectral index monitoring method doesn't seem like better than modified Observer’s Assessment of Alertness/Sedation Scale (MOAA/S) when the trained nurse monitored in moderate sedation.
2. The moderate sedative colonoscopy could be well performed by the trained nurse using MOAA/S even though the operator is less experienced.
ORIGINAL ARTICLES 2016 February 15
Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
1. Low-dose valsartan therapy reduced proteinuria significantly without causing any intolerability in normotensive immunoglobulin A nephropathy (IgAN) patients with minimal proteinuria and normal renal function.
2. To achieve an antiproteinuric effect, low-dose valsartan should be used for > 24 weeks in normotensive IgAN patients with minimal proteinuria.
ORIGINAL ARTICLES 2016 February 15
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
1. Co-treatment of deferasirox and imatinib showed anti-leukemic effects against both imatinib- sensitive and imatinib-resistant chronic myeloid leukemia cells.
2. Anti-leukemic effects of deferasirox are due to induction of apoptosis and cell cycle arrest by down-regulated expression of nuclear factor-κB and β-catenin levels.
ORIGINAL ARTICLES 2016 February 11
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
1. Acute appendicitis and familial Mediterranean fever (FMF) attack may be confused in emergency department and reliable markers to differentiate the two are required.
2. In this study, neutrophil to lymphocyte ratio was significantly higher in patients with acute appendicitis compared with those of FMF attack.
3. Prospective studies taking clinical presentation as well as several laboratory markers into account would provide additional clues to distinguish the two disorders.
Volume31 No. 2
Current Issue
Volume 31(2); March 2016
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Reviews
Diagnosis and management of gastric dysplasia
Korean J Intern Med. 2016;31(2):201-209.   Published online 2016 February 26
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Current concepts in the management of rheumatoid arthritis
Korean J Intern Med. 2016;31(2):210-218.   Published online 2016 February 26
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The specialist physician’s approach to rheumatoid arthritis in South Africa
Korean J Intern Med. 2016;31(2):219-236.   Published online 2016 February 26
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Editorial
Angiotensin converting enzyme inhibitors remain the first treatment of choice
Korean J Intern Med. 2016;31(2):237-241.   Published online 2016 February 26
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Original Articles
Gastroenterology
Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma
Korean J Intern Med. 2016;31(2):242-252.   Published online 2016 February 15
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Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
Korean J Intern Med. 2016;31(2):253-259.   Published online 2016 February 11
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Effects of bispectral index monitoring as an adjunct to nurse-administered propofol combined sedation during colonoscopy: a randomized clinical trial
Korean J Intern Med. 2016;31(2):260-266.   Published online 2016 February 26
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Cardiology
Angiotensin II type 1 receptor blockers as a first choice in patients with acute myocardial infarction
Korean J Intern Med. 2016;31(2):267-276.   Published online 2015 December 23
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Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
Korean J Intern Med. 2016;31(2):277-287.   Published online 2016 February 16
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Pulmonology
Bleeding complications in critically ill patients with liver cirrhosis
Korean J Intern Med. 2016;31(2):288-295.   Published online 2016 January 25
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Facility characteristics as independent prognostic factors of nursing home-acquired pneumonia
Korean J Intern Med. 2016;31(2):296-304.   Published online 2016 February 2
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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
Korean J Intern Med. 2016;31(2):305-312.   Published online 2016 January 29
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Endocrinology-metabolism
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Korean J Intern Med. 2016;31(2):313-322.   Published online 2015 December 23
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Nephrology
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice
Korean J Intern Med. 2016;31(2):323-334.   Published online 2016 February 26
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Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Korean J Intern Med. 2016;31(2):335-343.   Published online 2016 February 15
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Validation of the Korean coefficient for the modification of diet in renal disease study equation
Korean J Intern Med. 2016;31(2):344-356.   Published online 2016 January 13
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Hemato-oncology
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Korean J Intern Med. 2016;31(2):357-366.   Published online 2016 February 15
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Infectious diseases
Controlling endemic multidrug-resistant Acinetobacter baumannii in Intensive Care Units using antimicrobial stewardship and infection control
Korean J Intern Med. 2016;31(2):367-374.   Published online 2016 February 15
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Allergy
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Korean J Intern Med. 2016;31(2):375-385.   Published online 2015 December 23
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Rheumatology
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Korean J Intern Med. 2016;31(2):386-391.   Published online 2016 February 11
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Letters to the editor
Large Brunner’s gland hamartoma with annular stricture causing gastric outlet obstruction
Korean J Intern Med. 2016;31(2):392-395.   Published online 2016 January 25
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Series with complete resolution of left atrial appendage thrombi with apixaban in elderly patients
Korean J Intern Med. 2016;31(2):396-398.   Published online 2016 February 12
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Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy
Korean J Intern Med. 2016;31(2):399-402.   Published online 2016 February 26
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Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis
Korean J Intern Med. 2016;31(2):403-405.   Published online 2016 February 11
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Mixed-phenotype acute leukemia treated with decitabine
Korean J Intern Med. 2016;31(2):406-408.   Published online 2016 February 15
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Images of interest
Widespread intracranial calcifications in a patient with hypoparathyroidism
Korean J Intern Med. 2016;31(2):409-410.   Published online 2016 January 29
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Fluorodeoxyglucose-positron emission tomography/computed tomography imaging of squamous cell carcinoma arising in a meningomyelocele
Korean J Intern Med. 2016;31(2):411-412.   Published online 2015 December 23
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Letter to the editor
Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer
Korean J Intern Med. 2016;31(2):413-416.   Published online 2016 January 29
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