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ORIGINAL ARTICLES 2014 August 29
A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
1. The expression of protein disulfide isomerase (PDI) was increased in hepatocellular carcinoma (HCC) tissues compared to adjacent nontumor tissues. 2. The level of PDI expression was significantly associated with the Edmondson-Steiner grade. 3. Univariate and multivariate analyses revealed that high PDI expression was an independent predictor of a shorter time to progression and poorer overall survival of HCC patients who underwent surgical resection.
ORIGINAL ARTICLES 2014 August 29
Long-term outcomes of simple crossover stenting from the left main to the left anterior descending coronary artery
1. The long-term clinical outcomes of left main-to-left anterior descending coronary artery simple crossover stenting, without opening of a strut on the left circumflex coronary ostium, were accept-able. 2. Use of such a strategy reduces the need for additional complex left main bifurcation procedures, which may increase the risk of complications.
ORIGINAL ARTICLES 2014 August 29
Factors predictive of the failure of medical treatment in patients with pleural infection
1. A younger age < 50.5 years and shorter duration of chief complaint < 4.5 days were independent predictive factors for the medical treatment failure in patients with pleural infection. 2. Pleura l infection patients of relatively younger age and with a short duration of chief complaint should undergo surgical treatments to reduce the use of time-consuming medical management, or should undergo early surgical interventions without additional medical treatment after the failure of initial medical treatment. 3. This could be used as a new criteria for selection of the optimal treatment in patients with pleural infection.
ORIGINAL ARTICLES 2014 August 29
The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
1. Vitamin D levels are negatively related to insulin resistance (IR) and arterial stiffness. IR might link vitamin D deficiency and arterial stiffness in type 2 diabetic patients. However, no interventional trials of the effect of vitamin D on both IR and arterial stiffness in type 2 diabetes have been performed. 2. High-dose vitamin D supplementation had no beneficial effects on cardiovascular risk factors (glycemic control, lipid profiles, IR, blood pres-sure) or arterial stiffness (brachial-ankle pulse wave velocity and radial augmentation index) in vitamin D-deficient type 2 diabetic patients.
ORIGINAL ARTICLES 2014 August 29
SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes
1. SKI306X and its herbal components inhibit glycosaminoglycan degradation in human cartilage from osteoarthritis patients in part by down-regulating catabolic gene expression. 2. SK I306X fractions contain potential a disintegrin and metalloprotease with thrombospondin motifs-4 inhibitor(s).
ORIGINAL ARTICLES 2014 August 29
Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials
1. This meta-analysis shows that tofacitinib at dosages of 5 and 10 mg twice daily was effective in patients with active rheumatoid arthritis that had shown an inadequate response to disease-modifying antirheumatic drugs. 2. Tofacitinib had a manageable safety profile. 3. Long-term studies are needed to adequately assess the efficacy and safety of tofacitinib.
Volume29 No. 5
Current Issue
Volume 29(5); September 2014
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Reviews
Recent technological updates and clinical applications of induced pluripotent stem cells
Korean J Intern Med. 2014;29(5):547-557.   Published online 2014 August 29
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Crohn’s disease in Korea: past, present, and future
Korean J Intern Med. 2014;29(5):558-570.   Published online 2014 August 29
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Editorials
Adverse effects of long-term amiodarone therapy
Korean J Intern Med. 2014;29(5):571-573.   Published online 2014 August 29
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Is vitamin D supplementation really effective in patients with type 2 diabetes?
Korean J Intern Med. 2014;29(5):574-576.   Published online 2014 August 29
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Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?
Korean J Intern Med. 2014;29(5):577-579.   Published online 2014 August 29
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Original articles
A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
Korean J Intern Med. 2014;29(5):580-587.   Published online 2014 August 29
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The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice
Korean J Intern Med. 2014;29(5):588-596.   Published online 2014 August 29
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Long-term outcomes of simple crossover stenting from the left main to the left anterior descending coronary artery
Korean J Intern Med. 2014;29(5):597-602.   Published online 2014 August 29
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Factors predictive of the failure of medical treatment in patients with pleural infection
Korean J Intern Med. 2014;29(5):603-612.   Published online 2014 August 29
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The effects of secondhand smoke on chronic obstructive pulmonary disease in nonsmoking Korean adults
Korean J Intern Med. 2014;29(5):613-619.   Published online 2014 August 29
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The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Korean J Intern Med. 2014;29(5):620-629.   Published online 2014 August 29
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Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation
Korean J Intern Med. 2014;29(5):630-636.   Published online 2014 August 29
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Prevalence and impact of extended-spectrum β-lactamase production on clinical outcomes in cancer patients with Enterobacter species bacteremia
Korean J Intern Med. 2014;29(5):637-646.   Published online 2014 August 29
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SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes
Korean J Intern Med. 2014;29(5):647-655.   Published online 2014 August 29
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Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials
Korean J Intern Med. 2014;29(5):656-663.   Published online 2014 August 29
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Letters to the editor
Unexpected development of acute abdominal aortic thrombosis during percutaneous coronary intervention
Korean J Intern Med. 2014;29(5):664-666.   Published online 2014 August 29
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Adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with abnormal cortisol secretion mediated by catecholamines
Korean J Intern Med. 2014;29(5):667-670.   Published online 2014 August 29
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Immune thrombocytopenic purpura in a patient with renal cell carcinoma
Korean J Intern Med. 2014;29(5):671-674.   Published online 2014 August 29
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Cytomegalovirus appendicitis with concurrent bacteremia after chemotherapy for acute leukemia
Korean J Intern Med. 2014;29(5):675-678.   Published online 2014 August 29
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Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome
Korean J Intern Med. 2014;29(5):679-682.   Published online 2014 August 29
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Image of interest
Seropositive rheumatoid arthritis in a female patient with sensory neuropathy
Korean J Intern Med. 2014;29(5):683-684.   Published online 2014 August 29
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