1. The expression of protein disulfide isomerase (PDI) was increased in hepatocellular carcinoma (HCC) tissues compared to adjacent nontumor tissues. 2. The level of PDI expression was significantly associated with the Edmondson-Steiner grade. 3. Univariate and multivariate analyses revealed that high PDI expression was an independent predictor of a shorter time to progression and poorer overall survival of HCC patients who underwent surgical resection.
1. The long-term clinical outcomes of left main-to-left anterior descending coronary artery simple crossover stenting, without opening of a strut on the left circumflex coronary ostium, were accept-able. 2. Use of such a strategy reduces the need for additional complex left main bifurcation procedures, which may increase the risk of complications.
1. A younger age < 50.5 years and shorter duration of chief complaint < 4.5 days were independent predictive factors for the medical treatment failure in patients with pleural infection. 2. Pleura l infection patients of relatively younger age and with a short duration of chief complaint should undergo surgical treatments to reduce the use of time-consuming medical management, or should undergo early surgical interventions without additional medical treatment after the failure of initial medical treatment. 3. This could be used as a new criteria for selection of the optimal treatment in patients with pleural infection.
1. Vitamin D levels are negatively related to insulin resistance (IR) and arterial stiffness. IR might link vitamin D deficiency and arterial stiffness in type 2 diabetic patients. However, no interventional trials of the effect of vitamin D on both IR and arterial stiffness in type 2 diabetes have been performed. 2. High-dose vitamin D supplementation had no beneficial effects on cardiovascular risk factors (glycemic control, lipid profiles, IR, blood pres-sure) or arterial stiffness (brachial-ankle pulse wave velocity and radial augmentation index) in vitamin D-deficient type 2 diabetic patients.
1. SKI306X and its herbal components inhibit glycosaminoglycan degradation in human cartilage from osteoarthritis patients in part by down-regulating catabolic gene expression. 2. SK I306X fractions contain potential a disintegrin and metalloprotease with thrombospondin motifs-4 inhibitor(s).
1. This meta-analysis shows that tofacitinib at dosages of 5 and 10 mg twice daily was effective in patients with active rheumatoid arthritis that had shown an inadequate response to disease-modifying antirheumatic drugs. 2. Tofacitinib had a manageable safety profile. 3. Long-term studies are needed to adequately assess the efficacy and safety of tofacitinib.