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ORIGINAL ARTICLES 2015 December 28
New monoclonal antibody-based test for Helicobacter pylori urease in gastric tissue
1. The new monoclonal antibody-based test (Helicobacter pylori urease [HPU]) provided rapid and qualitative detection of HPU. 2. The HPU detected H. pylori urease in the presence of atrophic gastritis or intestinal metaplasia. It was unaffected by gastric aspirate ammonia or pH levels.
ORIGINAL ARTICLES 2015 December 28
Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea
1. The cut-off α-fetoprotein (AFP) value for early-stage hepatocellular carcinoma (HCC) is 17.4 ng/mL. 2. As a diagnostic tool for HCC, a cut-off of 100 ng/ mL is more sensitive than one of 200 ng/mL, with similar specificity and positive predictive value. 3. AFP still has a role in the diagnosis of HCC, and an appropriate AFP value may be 100 ng/mL rather than the previously reported value of 200 ng/mL.
ORIGINAL ARTICLES 2015 December 28
Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding
1. This study demonstrates that comorbidity of diabetes mellitus or metastatic malignancy, age ≥ 65 years and hemodynamic instability during hospitalization are risk factors of 30-day mortality in patients with nonvariceal upper gastrointestinal bleeding. 2. Early death was mainly caused by hemorrhage, whereas death after hospital discharge was mainly caused by patients’ comorbidities.
ORIGINAL ARTICLES 2015 December 28
Early monitoring for detection of antituberculous drug-induced hepatotoxicity
1. Of the 1,031 patients, hepatotoxicity occurred in 10.5% of patients who received antituberculous therapy. 2. The majority (67.6%) of hepatotoxicity events appeared within the first 30 days of treatment. 3. Earlier detection of hepatotoxicity enabled patients with antituberculous treatment to maintain the first-line drug regimen compared to later detection.
ORIGINAL ARTICLES 2015 December 28
Predictive value of CHADS2 score for cardiovascular events in patients with acute coronary syndrome and documented coronary artery disease
1. CHADS2 score may be capable of reflecting the severity of coronary artery obstructive disease and early diastolic dysfunction. 2. CHADS2 score showed a predictive value for cardiovascular and cerebrovascular events in acute coronary syndrome patients with documented coronary artery disease regardless of atrial fibrillation.
ORIGINAL ARTICLES 2015 December 28
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
1. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonists are known to have anti-inflammatory effects in chronic airway disease. 2. This study demonstrated that rosiglitazone inhalation has a protective effect on developing asthmatic airways through inhibiting Toll-like receptor 4 signaling pathways in an ovalbumin-challenged chronic asthma model. 3. Intranasal administration of the PPAR-γ agonist rosiglitazone may have therapeutic potential in asthma patients with few systemic side effects.
ORIGINAL ARTICLES 2015 December 28
Relationship between metabolic syndrome and thyroid nodules in healthy Koreans
1. There is a positive relationship between the components of metabolic syndrome (MS) and thyroid nodules in an ostensibly healthy Korean population. 2. A recent increase in thyroid nodules is partly due to increases in both MS and obesity.
Volume31 No. 1
Current Issue
Volume 31(1); January 2016
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Reviews
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Korean J Intern Med. 2016;31(1):1-14.   Published online 2015 December 28
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Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Korean J Intern Med. 2016;31(1):15-29.   Published online 2015 December 28
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The antibacterial effect of fatty acids on Helicobacter pylori infection
Korean J Intern Med. 2016;31(1):30-35.   Published online 2015 December 28
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Editorial
Can a high-flow nasal cannula substitute for noninvasive positive pressure ventilation in post-extubation respiratory failure?
Korean J Intern Med. 2016;31(1):36-39.   Published online 2015 December 28
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Original Articles
Gastroenterology
New monoclonal antibody-based test for Helicobacter pylori urease in gastric tissue
Korean J Intern Med. 2016;31(1):40-45.   Published online 2015 December 28
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Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea
Korean J Intern Med. 2016;31(1):46-53.   Published online 2015 December 28
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Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding
Korean J Intern Med. 2016;31(1):54-64.   Published online 2015 December 28
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Early monitoring for detection of antituberculous drug-induced hepatotoxicity
Korean J Intern Med. 2016;31(1):65-72.   Published online 2015 December 28
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Cardiology
Predictive value of CHADS2 score for cardiovascular events in patients with acute coronary syndrome and documented coronary artery disease
Korean J Intern Med. 2016;31(1):73-81.   Published online 2015 December 28
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Pulmonology
Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure
Korean J Intern Med. 2016;31(1):82-88.   Published online 2015 December 28
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Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Korean J Intern Med. 2016;31(1):89-97.   Published online 2015 December 28
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Endocrinology-metabolism
Relationship between metabolic syndrome and thyroid nodules in healthy Koreans
Korean J Intern Med. 2016;31(1):98-105.   Published online 2015 December 28
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Nephrology
Impact of dialysis modality on technique survival in end-stage renal disease patients
Korean J Intern Med. 2016;31(1):106-115.   Published online 2015 December 28
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Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Korean J Intern Med. 2016;31(1):116-124.   Published online 2015 December 28
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Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection
Korean J Intern Med. 2016;31(1):125-133.   Published online 2015 December 28
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Hemato-oncology
Evaluation of treatment response and tissue necrosis as prognostic indicators following neoadjuvant chemoradiotherapy in rectal cancer patients
Korean J Intern Med. 2016;31(1):134-144.   Published online 2015 December 28
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Infectious diseases
Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli
Korean J Intern Med. 2016;31(1):145-155.   Published online 2015 December 28
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Amikacin therapy for urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Korean J Intern Med. 2016;31(1):156-161.   Published online 2015 December 28
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Risk factors and etiology of surgical site infection after radical neck dissection in patients with head and neck cancer
Korean J Intern Med. 2016;31(1):162-169.   Published online 2015 December 28
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Rheumatology
Validation and reliability of a Behcet’s Syndrome Activity Scale in Korea
Korean J Intern Med. 2016;31(1):170-175.   Published online 2015 December 28
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Letters to the editor
Successful transcatheter closure of an inferior sinus venosus atrial septal defect
Korean J Intern Med. 2016;31(1):176-178.   Published online 2015 December 28
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Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis
Korean J Intern Med. 2016;31(1):179-183.   Published online 2015 December 28
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Diagnosis of cyclic Cushing syndrome using the morning urine free cortisol to creatinine ratio
Korean J Intern Med. 2016;31(1):184-187.   Published online 2015 December 28
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First Korean case of Emberger syndrome (primary lymphedema with myelodysplasia) with a novel GATA2 gene mutation
Korean J Intern Med. 2016;31(1):188-190.   Published online 2015 December 28
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Epithelioid sarcoma with spontaneous pneumothorax and massive pleural effusion
Korean J Intern Med. 2016;31(1):191-193.   Published online 2015 December 28
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Co-existing proteinase 3-antineutrophil cytoplasmic antibody-associated vasculitis with immunoglobulin A nephropathy
Korean J Intern Med. 2016;31(1):194-196.   Published online 2015 December 28
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Images of interest
Daughter cysts in a cyst of the liver: hepatic echinococcosis
Korean J Intern Med. 2016;31(1):197-198.   Published online 2015 December 28
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A hundred years after the first article, a recollection: Cabot ring
Korean J Intern Med. 2016;31(1):199-199.   Published online 2015 December 28
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