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											 Original Article											 
											Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
											
																								
												Jeong-Sup Song, Kyung-Sook Cho, Hyung-Kyu Yoon, Hwa-Sik Moon, Sung-Hak Park 
												
												Korean J Intern Med. 2005;20(4):275-283.   Published online December 31, 2005												 
																										
												
												
																								
													BackgroundNeutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway through which NE induces MUC5AC gene expression in bronchial..												  
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