Hemato-oncology / Original Article Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia Jung Min Lee, Do Young Kim, Hee Jeong Cho, Joon Ho Moon, Sang Kyun Sohn, Ho Jin Shin, Young Rok Do, Mi Hwa Heo, Min Kyoung Kim, Young Seob Park, Dong Won Baek Korean J Intern Med. 2025;40(1):124-134.   Published online January 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.227                      Background/Aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction..

Hemato-oncology / Original Article The characteristics of Korean elderly multiple myeloma patients aged 80 years or over Sang Hwan Lee, Hee-Jeong Cho, Joon Ho Moon, Ji Yoon Jung, Min Kyoung Kim, Mi Hwa Heo, Young Rok Do, Yunhwi Hwang, Sung Hwa Bae Korean J Intern Med. 2025;40(1):115-123.   Published online January 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.041                      Background/Aims: Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed. Methods: This retrospective multicenter st..

Hemato-oncology / Original Article Geriatric risk model for older patients with diffuse large B-cell lymphoma (GERIAD): a prospective multicenter cohort study Ho-Young Yhim, Yong Park, Jeong-A Kim, Ho-Jin Shin, Young Rok Do, Joon Ho Moon, Min Kyoung Kim, Won Sik Lee, Dae Sik Kim, Myung-Won Lee, Yoon Seok Choi, Seong Hyun Jeong, Kyoung Ha Kim, Jinhang Kim, Chang-Hoon Lee, Ga-Young Song, Deok-Hwan Yang, Jae-Yong Kwak Korean J Intern Med. 2024;39(3):501-512.   Published online January 30, 2024 DOI: https://doi.org/10.3904/kjim.2023.265              Web of Science 3    Crossref 3                      Background/Aims: Optimal risk stratification based on simplified geriatric assessment to predict treatment-related toxicity and survival needs to be clarified in older patients with diffuse large B-cell lymphoma (DLBCL). Methods: This multicenter prospective cohort study enrolled newly diagnosed pat..

Hemato-oncology / Original Article Prognostic Significance Of Sequential 18f-fdg Pet/Ct During Frontline Treatment Of Peripheral T Cell Lymphomas Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Mihee Kim, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang Korean J Intern Med. 2024;39(2):327-337.   Published online January 25, 2024 DOI: https://doi.org/10.3904/kjim.2023.323                      Background/Aims: The prognostic significance of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential 18F-FDG PET/CT during frontline chemo..

Hemato-oncology / Review Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy Jae-Ho Yoon, Seok Lee Korean J Intern Med. 2024;39(1):34-56.   Published online January 1, 2024 DOI: https://doi.org/10.3904/kjim.2023.407              Web of Science 3    Crossref 3                 Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..

Hemato-oncology / Original Article Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim Korean J Intern Med. 2023;38(6):893-902.   Published online August 21, 2023 DOI: https://doi.org/10.3904/kjim.2023.134              Web of Science 1    Crossref 2                 Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge. Methods: We developed a rituximab-resistant cell line (RRCL) by sequential exposure to gradually increasi..

Hemato-oncology / Review Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms Seug Yun Yoon, Sung-Yong Kim Korean J Intern Med. 2023;38(6):810-817.   Published online November 1, 2023 DOI: https://doi.org/10.3904/kjim.2023.333              Web of Science 3    Crossref 3                 Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. The progression of MPNs follows a biolog..

Hemato-oncology / Editorial Identifying and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing Youngwoo Jeon Korean J Intern Med. 2023;38(6):785-786.   Published online November 1, 2023 DOI: https://doi.org/10.3904/kjim.2023.437

Hemato-oncology / Original Article Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06) Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi Korean J Intern Med. 2023;38(5):747-757.   Published online June 26, 2023 DOI: https://doi.org/10.3904/kjim.2022.408              Web of Science 2    Crossref 2                      Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL. Methods: A t..

Hemato-oncology / Original Article Rituximab plus multiagent chemotherapy for newly diagnosed CD20-positive acute lymphoblastic leukemia: a prospective phase II study Dong Won Baek, Han-Seung Park, Sang Kyun Sohn, Dae Young Kim, Inho Kim, Jae-Sook Ahn, Young Rok Do, Se Ryeon Lee, Hyeon-Seok Eom, Won-Sik Lee, Sung-Hyun Kim, Ho Sup Lee, Yoo Jin Lee, Joon Ho Moon, Je-Hwan Lee; Adult Acute Lymphoblastic Leukemia Working Party, the Korean Society of Hematology Korean J Intern Med. 2023;38(5):734-746.   Published online June 20, 2023 DOI: https://doi.org/10.3904/kjim.2022.401              Web of Science 7    Crossref 7                      Background/Aims: We performed a prospective study to determine the efficacy and safety of rituximab including chemotherapy in CD20-positive acute lymphoblastic leukemia (ALL). Methods: Patients with newly diagnosed ALL, aged ≥ 15 years, were eligible for the study if their leukemic blast cells in ..

Hemato-oncology / Erratum Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/refractory multiple myeloma Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon Korean J Intern Med. 2023;38(4):578-578.   Published online June 9, 2023 DOI: https://doi.org/10.3904/kjim.2022.183e Corrects: Korean J Intern Med 2023 3; 38(2): 238

Hemato-oncology / Image of interest Asymptomatic huge spleen mass Sanghyeok Han, Kyeongmin Kim, In Ho Choi, Jong-Ho Won, Seug Yun Yoon Korean J Intern Med. 2023;38(4):576-577.   Published online June 9, 2023 DOI: https://doi.org/10.3904/kjim.2022.335

Hemato-oncology / Original Article The prognostic impact of reduced variant burden in elderly patients with acute myeloid leukemia treated with decitabine Mihee Kim, TaeHyung Kim, Seo-Yeon Ahn, Jun Hyung Lee, Ju Heon Park, Myung-Geun Shin, Sung-Hoon Jung, Ga-Young Song, Deok-Hwan Yang, Je-Jung Lee, Seung Hyun Choi, Mi Yeon Kim, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim Korean J Intern Med. 2023;38(4):534-545.   Published online June 9, 2023 DOI: https://doi.org/10.3904/kjim.2022.396                      Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy. Methods: A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We an..

Hemato-oncology / Image of interest Fever of unknown origin caused by hemophagocytic lymphohistiocytosis associated with diffuse large B-cell lymphoma Min-Sun Kim, Bohyun Kim, Han-Jo Kim, Sang-Cheol Lee Korean J Intern Med. 2023;38(3):448-449.   Published online April 7, 2023 DOI: https://doi.org/10.3904/kjim.2023.025

Hemato-oncology / Original Article Efficacy of the granisetron transdermal system for the control of nausea and vomiting induced by highly emetogenic chemotherapy: a multicenter, randomized, controlled trial Der Sheng Sun, Yoon Ho Ko, Jong Youl Jin, In Sook Woo, Suk Young Park, Yun Ae Eom, Jin Hyoung Kang, Hoon Kyo Kim Korean J Intern Med. 2023;38(3):406-416.   Published online March 11, 2022 DOI: https://doi.org/10.3904/kjim.2020.359              Web of Science 4    Crossref 5                      Background/Aims: We compared the efficacy of the granisetron transdermal system (GTS) with that of ondansetron for controlling chemotherapy-induced nausea and vomiting (CINV) in patients treated with highly emetogenic chemotherapy (HEC). Methods: We randomized a total of 389 patients to groups trea..

Hemato-oncology / Original Article Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma [corrected-article] Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon Korean J Intern Med. 2023;38(2):238-247.   Published online January 26, 2023 DOI: https://doi.org/10.3904/kjim.2022.183              Web of Science 1   Correction in: Korean J Intern Med 2023 7; 38(4): 578                      Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for pre..