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Infectious diseases / Review
Appropriate timing of antibiotic initiation in patients with sepsis or septic shock: a systematic review and meta-analysis
Nam Su Ku, Yongseop Lee, Dae Won Park
Korean J Intern Med. 2025;40(5):725-733. Published online August 26, 2025
Evidence supporting antibiotic administration within 3 hours in sepsis without shock is limited. Therefore, we conducted a systematic review and meta-analysis to determine whether the timing of antibiotic initiation influences mortality in patients with sepsis or septic shock. We comprehensively searched Pub..
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Gastroenterology / Original Article
Prevalence and predictors of multidrug-resistant bacteremia in liver cirrhosis
Aryoung Kim, Byeong Geun Song, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh
Korean J Intern Med. 2024;39(3):448-457. Published online April 30, 2024
Background/Aims: Improved knowledge of local epidemiology and predicting risk factors of multidrug-resistant (MDR) bacteria are required to optimize the management of infections. This study examined local epidemiology and antibiotic resistance patterns of liver cirrhosis (LC) patients and evaluated ..
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Infectious diseases / Review
Implementing antimicrobial stewardship: lessons and perspectives from a university-affiliated tertiary hospital in Korea
Soo Jin Lee, Raeseok Lee, Sung-Yeon Cho, Dukhee Nho, Hye Lim Ahn, Dong-Gun Lee
Korean J Intern Med. 2024;39(3):399-412. Published online April 30, 2024
Antimicrobial stewardship programs (ASPs) can lower antibiotic use, decrease medical expenses, prevent the emergence of resistant bacteria, and enhance treatment for infectious diseases. This study summarizes the stepwise implementation and effects of ASPs in a single university-affiliated tertiary ..
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Pulmonology / Original Article
The impact of antimicrobial de-escalation therapy in culture-negative pneumonia: a systematic review and meta-analysis
Jae-Uk Song, Jonghoo Lee
Korean J Intern Med. 2023;38(5):704-713. Published online August 17, 2023
Background/Aims: Antimicrobial de-escalation (ADE) remains a challenging strategy in the treatment of pneumonia. We investigated the outcomes of ADE as measured by mortality and duration of the use of antibiotics in patients with culture- negative pneumonia.
Methods: We performed a systematic revie..
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Pulmonology / Original Article
Clinical outcomes of and risk factors for secondary infection in patients with severe COVID-19: a multicenter cohort study in South Korea
Yong Sub Na, Ae-Rin Baek, Moon Seong Baek, Won-Young Kim, Jin Hyoung Kim, Bo young Lee, Gil Myeong Seong, Song-I Lee
Korean J Intern Med. 2023;38(1):68-79. Published online November 24, 2022
Background/Aims: Secondary infection with influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, there is limited information about it in patients with severe coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical outco..
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Review
Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria
Hyo-Jin Lee, Dong-Gun Lee
Korean J Intern Med. 2022;37(2):271-280. Published online February 28, 2022
Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received regulatory approval in the United States. However, few new antibiotics have been introduced in Rep..
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Review
Desensitization for the prevention of drug hypersensitivity reactions
Sung-Yoon Kang, Jeongmin Seo, Hye-Ryun Kang
Korean J Intern Med. 2022;37(2):261-270. Published online February 28, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose. It can be used as a therapeutic strategy for patients with drug hypersensitivity when no comparable alternativ..
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Infectious diseases / Original Article
Evaluation of copper alloys for reducing infection by methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus faecium in intensive care unit and in vitro
Sung Im Choi, Mee Soo Chang, Taeeun Kim, Kyung Hwa Chung, Seongman Bae, Sung-Han Kim, Chan Jin Yoon, Young Kyoon Kim, Jun Hee Woo
Korean J Intern Med. 2021;36(5):1204-1210. Published online August 18, 2021
Background/Aims: Multi-drug resistant pathogens are increasing among healthcare-associated infections. It is well known that copper and copper alloys have antimicrobial activity. We evaluated the activity of copper against bacteria in a hospital setting in Korea.
Methods: This study was conducted i..
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Gastroenterology / Original Article
Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation
Mun Sun Choi, Eun Young Ze, Jae Yong Park, Tae-Seop Shin, Jae Gyu Kim
Korean J Intern Med. 2021;36(4):854-867. Published online November 27, 2020
Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the effects of H. pylori-derived OMVs.
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Infectious diseases / Original Article
Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-jae Lee, Hyunjoo Pai
Korean J Intern Med. 2020;35(3):703-713. Published online September 27, 2018
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each ..
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Infectious diseases / Original Article
Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis
Jungok Kim, Cheol-In Kang, Geum-Youn Gwak, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2020;35(1):215-221. Published online March 5, 2018
Background/Aims: Healthcare-associated (HCA) infection is a recently suggested new category of community-onset infections. The implications of HCA infections in terms of diagnosis, treatment, and outcomes of spontaneous bacterial peritonitis (SBP) are not well understood. We sought to delineate the ..
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Infectious diseases / Original Article
Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi
Muhammad Shamshir Alam, Krishna Kolappa Pillai, Syed Aliul Hasan Abdi, Prem Kapur, Paru Kutty Pillai, Kandasamy Nagarajan
Korean J Intern Med. 2018;33(6):1203-1209. Published online September 6, 2017
Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia.
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Nephrology / Original Article
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
Korean J Intern Med. 2017;32(3):505-513. Published online March 25, 2016
Background/Aims: There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vi..
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Gastroenterology / Review
The antibacterial effect of fatty acids on Helicobacter pylori infection
Sung Woo Jung, Sang Woo Lee
Korean J Intern Med. 2016;31(1):30-35. Published online December 28, 2015
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have dec..
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Infectious diseases / Original Article
Drug utilization review of mupirocin ointment in a Korean university-affiliated hospital
Sung Hee Youn, Seung Soon Lee, Sukyeon Kim, Jeong-a Lee, Bum Joon Kim, Jounghee Kim, Hye-kyung Han, Jae-Seok Kim
Korean J Intern Med. 2015;30(4):515-520. Published online June 29, 2015
Background/Aims: Intranasa l mupirocin and chlorhexidine bathing are candidate strategies to prevent healthcare-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In Korea, intranasal mupirocin is not available, and mupirocin ointment, an over-the-counter drug..
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Infectious diseases / Original Article
Clinical and microbiological features of Providencia bacteremia: experience at a tertiary care hospital
Hee Kyoung Choi, Young Keun Kim, Hyo Youl Kim, Jeong Eun Park, Young Uh
Korean J Intern Med. 2015;30(2):219-225. Published online February 27, 2015
Background/Aims: Providencia species frequently colonize urinary catheters and cause urinary tract infections (UTIs); however, bacteremia is uncommon and not well understood. We investigated the clinical features of Providencia bacteremia and the antibiotic susceptibility of Provide..
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Original Article
Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum β-Lactamase Production in Proteus mirabilis Bacteremia
Kyung Mok Sohn, Cheol-In Kang, Eun-Jeong Joo, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2011;26(1):89-93. Published online March 3, 2011
Background/AimsWe evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance. MethodsFrom October 2000 to July 2009, 37 patients with clinically signific..
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Original Article
The Current Practice of Skin Testing for Antibiotics in Korean Hospitals
So Hee Lee, Heung Woo Park, Sae Hoon Kim, Yoon Seok Chang, Sun Sin Kim, Sang Heon Cho, Kyung Up Min, You Young Kim
Korean J Intern Med. 2010;25(2):207-212. Published online June 1, 2010
Background/AimsAntibiotic skin testing is a useful procedure for identifying patients with IgE-mediated hypersensitivity to antibiotics. The procedures, however, have not been standardized, and the testing is performed with diverse protocols in Korean hospitals wards. Thus, we..
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Case Report
Klebsiella pneumoniae Orbital Cellulitis with Extensive Vascular Occlusions in a Patient with Type 2 Diabetes
Sae Jeong Yang, Soo Yeon Park, Yun Jeong Lee, Hee Young Kim, Ji A Seo, Sin Gon Kim, Dong Seop Choi
Korean J Intern Med. 2010;25(1):114-117. Published online February 26, 2010
A 39-year-old woman visited the emergency room complaining of right eye pain and swelling over the preceding three days. The ophthalmologist's examination revealed orbital cellulitis and diabetic retinopathy in the right eye, although the patient had no prior diagnosis of diabetes. It was therefo..
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