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Review
Proprotein convertase subtilisin/kexin type 9 inhibition in cardiovascular disease: current status and future perspectives
Kyung Hoon Cho, Young Joon Hong
Korean J Intern Med. 2020;35(5):1045-1058. Published online August 28, 2020
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the degradation of low-density lipoprotein (LDL) receptors; it has been proved that its inhibition improves cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease (ASCVD). Herein, we review the current..
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Cardiology / Original Article
Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry
Han Joon Bae, Yun-Kyeong Cho, Hyoung-Seob Park, Hyuck-Jun Yoon, Hyungseop Kim, Seongwook Han, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim, Jae-Kean Ryu, Deug Young Nah, Chang-Wook Nam
Korean J Intern Med. 2020;35(2):342-350. Published online August 19, 2019
Background/Aims: To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and safety through the prospective Daegu and Gyeong..
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Endocrinology-metabolism / Original Article
Validation of the Friedewald formula for estimating low density lipoprotein cholesterol: the Korea National Health and Nutrition Examination Survey, 2009 to 2011
Jongseok Lee, Sungok Jang, Haemin Jeong, Ohk-Hyun Ryu
Korean J Intern Med. 2020;35(1):150-159. Published online March 21, 2018
Background/Aims: The aim of this study is to compare Friedewald-estimated and directly measured low density lipoprotein cholesterol (LDL-C) values and assess the concordance in guideline risk classification between the two methods.
Methods: The data were derived from the 2009 to 2011 Korea National..
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Cardiology / Original Article
Efficacy and safety of alirocumab in Korean patients with hypercholesterolemia and high cardiovascular risk: subanalysis of the ODYSSEY-KT study
Chang-Wook Nam, Dong-Soo Kim, Jianyong Li, Marie T. Baccara-Dinet, Ivy Li, Ji-Hyun Kim, Chong-Jin Kim
Korean J Intern Med. 2019;34(6):1252-1262. Published online September 1, 2018
Background/Aims: Efficacy and safety data of alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), is not yet well established in the Korean population. We assessed them in ODYSSEY-KT through the pre-specified Korean subanalysis.
Methods: In the ODY..
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Endocrinology-metabolism / Original Article
ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels
Ji Eun Jun, Young Ju Choi, Yong-Ho Lee, Dae Jung Kim, Seok Won Park, Byung Wook Huh, Eun Jig Lee, Sun-Ha Jee, Kyu Yeon Hur, Sung Hee Choi, Kap Bum Huh
Korean J Intern Med. 2018;33(1):138-147. Published online December 28, 2017
Background/Aims: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein cholesterol (LDL-C) levels less than 100 mg/dL. Methods: This cross-secti..
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Rheumatology / Original Article
Factors related to outcomes in lupus-related protein-losing enteropathy
Doo-Ho Lim, Yong-Gil Kim, Seung-Hyeon Bae, Soomin Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2015;30(6):906-912. Published online October 30, 2015
Background/Aims: Protein-losing enteropathy (PLE), characterized by severe hypoalbuminemia and peripheral edema, is a rare manifestation of systemic lupus erythematosus. This present study aimed to identify the distinctive features of lupus-related PLE and evaluate the factors related to the treatme..
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Original Article
Characteristics of Subjects with Very Low Serum Low-Density Lipoprotein Cholesterol and the Risk for Intracerebral Hemorrhage
Jae-Geun Lee, Sung Joo Koh, So Yeon Yoo, Jung Re Yu, Sang Ah Lee, Gwanpyo Koh, Daeho Lee
Korean J Intern Med. 2012;27(3):317-326. Published online September 1, 2012
Background/AimsThe clinical implications of hypocholesterolemia have not been well studied, although some studies have revealed an association between hypocholesterolemia and intracerebral hemorrhage (ICH). We evaluated the clinical characteristics of subjects with very low-de..
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Original Article
Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
Jong-Seon Park, Young-Jo Kim, Ji-Yong Choi, Yoon-Nyun Kim, Teck-Jong Hong, Dong-Soo Kim, Ki-Young Kim, Myung-Ho Jeong, Jei-Keon Chae, Seok-Kyu Oh, In-Whan Seong
Korean J Intern Med. 2010;25(1):27-35. Published online February 26, 2010
Background/AimsThis multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic metabolic syndrome. MethodsIn tot..
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Original Article
Flexible Initial Dosing of Atorvastatin Based Upon Initial Low-Density Lipoprotein Cholesterol Levels in Type 2 Diabetic Patients
Korean J Intern Med. 2008;23(1):22-29. Published online March 20, 2008
Background/AimsWe used flexible starting doses and early titration of atorvastatin to determine the rate of achievement of a low-density lipoprotein cholesterol (LDL-C) target for hyperlipidemic patients with type 2 diabetes mellitus. Me.. </div>
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