Cardiology / Original Article
Contemporary use of lipid-lowering therapy for secondary prevention in Korean patients with atherosclerotic cardiovascular diseases
Su-Yeon Choi, Bo Ram Yang, Hyun-Jae Kang, Kyong Soo Park, Hyo-Soo Kim
Korean J Intern Med. 2020;35(3):593-604. Published online November 25, 2019
Background/Aims: We evaluated the contemporary use of lipid-lowering therapy (LLT) in Korean patients with atherosclerotic cardiovascular disease (ASCVD), and identified factors associated with statin non-prescription.
Methods: Using the Korean Health Insurance Review and Assessment data, we identi..
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Allergy / Original Article
Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2018;33(6):1210-1223. Published online April 19, 2018
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in o..
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Rheumatology / Original Article
Atorvastatin inhibits osteoclast differentiation by suppressing NF-κB and MAPK signaling during IL-1β-induced osteoclastogenesis
Won-Seok Lee, Eun-Gyeong Lee, Myung-Soon Sung, Yun-Jung Choi, Wan-Hee Yoo
Korean J Intern Med. 2018;33(2):397-406. Published online March 28, 2017
Background/Aims: To define the effect of statins on interleukin 1β (IL-1β)-induced osteoclastogenesis and elucidate the underlying mechanisms.
Methods: Bone marrow cells were obtained from 5-week-old male ICR (Institute for Cancer Research) mice, and they were cultured to differentiate them into ..
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Cardiology / Original Article
Effects of intensive versus mild lipid lowering by statins in patients with ischemic congestive heart failure: Korean Pitavastatin Heart Failure (SAPHIRE) study
Hae-Young Lee, Hyun-Jai Cho, Hee-Yul Kim, Hee-Kyung Jeon, Joon Han Shin, Suk-Min Kang, Sang Hong Baek
Korean J Intern Med. 2014;29(6):754-763. Published online October 31, 2014
Background/Aims: This study was designed to evaluate the dose-effect relationship of statins in patients with ischemic congestive heart failure (CHF), since the role of statins in CHF remains unclear.
Methods: The South koreAn Pitavastatin Heart FaIluRE (SAPHIRE) study was designed to randomize pat..
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Original Article
Characteristics of Subjects with Very Low Serum Low-Density Lipoprotein Cholesterol and the Risk for Intracerebral Hemorrhage
Jae-Geun Lee, Sung Joo Koh, So Yeon Yoo, Jung Re Yu, Sang Ah Lee, Gwanpyo Koh, Daeho Lee
Korean J Intern Med. 2012;27(3):317-326. Published online September 1, 2012
Background/AimsThe clinical implications of hypocholesterolemia have not been well studied, although some studies have revealed an association between hypocholesterolemia and intracerebral hemorrhage (ICH). We evaluated the clinical characteristics of subjects with very low-de..
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Case Report
Duodenal Somatostatinoma: A Case Report and Review
Jung A Kim, Won-Ho Choi, Chul Nam Kim, Young Soo Moon, Sun Hee Chang, Hye Ran Lee
Korean J Intern Med. 2011;26(1):103-107. Published online March 2, 2011
Somatostatinomas are rare functioning carcinoid tumors that usually arise in the pancreas and duodenum. They are seldom associated with typical clinical symptoms; their diagnosis is confirmed only by histological and immunohistochemical studies and the presence of specific hormones. Two distinct ..
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Original Article
Role of 68Ga-DOTATOC PET/CT in the Evaluation of Primary Pulmonary Carcinoids
Tarun Jindal, Arvind Kumar, Balasubramanian Venkitaraman, Roman Dutta, Rakesh Kumar
Korean J Intern Med. 2010;25(4):386-391. Published online November 27, 2010
Background/AimsAlthough carcinoid tumors usually have good prognosis, early and specific diagnosis is important. Computed tomography and magnetic resonance imaging do not provide findings that are specific for carcinoids, and somatostatin receptor scintigraphy suffers from low..
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Original Article
Application of Cystatin C Reduction Ratio to High-Flux Hemodialysis as an Alternative Indicator of the Clearance of Middle Molecules
Joon-Sung Park, Gheun-Ho Kim, Chong Myung Kang, Chang Hwa Lee
Korean J Intern Med. 2010;25(1):77-81. Published online February 26, 2010
Background/AimsAlthough high-flux (HF) dialyzers with enhanced membrane permeability are widely used in current hemodialysis (HD) practice, urea kinetic modeling is still being applied to indicate the adequacy of both low-flux (LF) and HF HD. In comparison with urea (molecular..
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Original Article
Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
Jong-Seon Park, Young-Jo Kim, Ji-Yong Choi, Yoon-Nyun Kim, Teck-Jong Hong, Dong-Soo Kim, Ki-Young Kim, Myung-Ho Jeong, Jei-Keon Chae, Seok-Kyu Oh, In-Whan Seong
Korean J Intern Med. 2010;25(1):27-35. Published online February 26, 2010
Background/AimsThis multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic metabolic syndrome. MethodsIn tot..
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Original Article
The Efficacy and Safety of Ezetimibe and Low-Dose Simvastatin as a Primary Treatment for Dyslipidemia in Renal Transplant Recipients
Hye Eun Yoon, Joon Chang Song, Bok Jin Hyoung, Hyeon Seok Hwang, So Young Lee, Youn Joo Jeon, Bum Soon Choi, Yong Soo Kim, Chul Woo Yang
Korean J Intern Med. 2009;24(3):233-237. Published online August 26, 2009
Background/AimsThe efficacy and safety of a combination of ezetimibe and low-dose statin as primary treatment for dyslipidemia in renal transplant patients were evaluated prospectively. MethodsThe study enrolled 77 renal transplant recipients wi..
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Original Article
Flexible Initial Dosing of Atorvastatin Based Upon Initial Low-Density Lipoprotein Cholesterol Levels in Type 2 Diabetic Patients
Korean J Intern Med. 2008;23(1):22-29. Published online March 20, 2008
Background/AimsWe used flexible starting doses and early titration of atorvastatin to determine the rate of achievement of a low-density lipoprotein cholesterol (LDL-C) target for hyperlipidemic patients with type 2 diabetes mellitus. Me..
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