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Gastroenterology / Original Article
The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2
Sung Yong Han, Hyun Young Woo, Jeong Heo, Sang Gyu Park, Sung Ik Pyeon, Young Joo Park, Dong Uk Kim, Gwang Ha Kim, Hyung Hoi Kim, Geun Am Song, Mong Cho
Korean J Intern Med. 2021;36(3):544-556. Published online March 19, 2019
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical ..
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Gastroenterology / Original Article
Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma
Byung Soo Kwan, Jeong Han Kim, Seong Jun Park, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2021;36(2):292-304. Published online April 3, 2020
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC pati..
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Gastroenterology / Original Article
Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Korean J Intern Med. 2020;35(1):65-78. Published online June 17, 2019
Background/Aims: We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea.
Methods: A total of 447 consecutive treatment-naïve NBNC-HCC adult patients who were r..
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Gastroenterology / Original Article
Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Korean J Intern Med. 2019;34(6):1223-1232. Published online October 26, 2018
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods: This study analyzed 175 conse..
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Gastroenterology / Original Article
Clinical significance of radiation-induced liver disease after stereotactic body radiation therapy for hepatocellular carcinoma
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Korean J Intern Med. 2018;33(6):1093-1102. Published online August 28, 2017
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD.
Methods: We retrospectively rev..
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Letter to the editor
Hepatocellular carcinoma hidden by multiple infarcted regenerative nodules
Jin Ah Kim, Hye Sung Ahn, Haneul Park, Yoo Rim Seo, Ju Hyun Seo, Chang Wook Kim, Hee Yeon Kim
Korean J Intern Med. 2016;31(6):1178-1180. Published online February 18, 2016
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Gastroenterology / Original Article
Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea
Dae Geon Ahn, Hyung Joon Kim, Hyun Kang, Hyun Woong Lee, Si Hyun Bae, Joon Hyoek Lee, Yong Han Paik, June Sung Lee
Korean J Intern Med. 2016;31(1):46-53. Published online December 28, 2015
Background/Aims: The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients.
Methods: We retrospectively reviewed the medical records of HCC and cirrhosis patients at three hospitals. For each HCC patient..
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Gastroenterology / Original Article
Use of 18F-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
Min Jin Kim, Young Seok Kim, Youn Hee Cho, Hee Yoon Jang, Jeong-Yeop Song, Sae Hwan Lee, Soung Won Jeong, Sang Gyune Kim, Jae Young Jang, Hong Su Kim, Boo Sung Kim, Won Hyung Lee, Jung Mi Park, Jae Myung Lee, Min Hee Lee, Deuk Lin Choi
Korean J Intern Med. 2015;30(3):308-315. Published online April 29, 2015
Background/Aims: 18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and sur..
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Gastroenterology / Original Article
A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
Su Jong Yu, Jae-Kyung Won, Han Suk Ryu, Won-Mook Choi, Hyeki Cho, Eun-Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Kyung-Suk Suh, Ja-June Jang, Chung Yong Kim, Hyo-Suk Lee, Jung-Hwan Yoon, Kwang-Hyun Cho
Korean J Intern Med. 2014;29(5):580-587. Published online August 28, 2014
Background/Aims: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has..
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Case Report
Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma
Suh Yoon Yang, Bong Ki Cha, Gihyeon Kim, Hyun Woong Lee, Jae Gyu Kim, Sae Kyung Chang, Hyung Joon Kim
Korean J Intern Med. 2014;29(2):231-235. Published online February 27, 2014
Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian c..
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Gastroenterology / Review
Newer treatments for advanced hepatocellular carcinoma
Myeong Jun Song, Si Hyun Bae
Korean J Intern Med. 2014;29(2):149-155. Published online February 27, 2014
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The only curative treatment modalities for HCC are surgery, percutaneous ablation, and liver transplantation. Unfortunately, the majority of patients have unresectable disease at diagnosis. Therefore, effective treatment opt..
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Case Report
Hepatoduodenal fistula formation following
transcatheter arterial chemoembolization and
radiotherapy for hepatocellular carcinoma:
treatment with endoscopic Histoacryl injection
Jaryong Jeon, Joonseong Ahn, Hongseok Yoo, Taek Kyu Park, Dongmo Je, Hyemin Jeong, Kwang Hyuck Lee
Korean J Intern Med. 2014;29(1):101-105. Published online January 2, 2014
A 71-year-old male patient was readmitted to our hospital 1 month after discharge
because of relapse of abdominal pain. He had been diagnosed with hepatocellular
carcinoma (HCC) 1 year prior and had undergone repeated transcatheter arterial
chemoembolization and radiotherapy. During the last hosp..
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Letter to the editor
Hemothorax caused by spontaneous rupture of a metastatic mediastinal lymph node in hepatocellular carcinoma: a case report
Ssang Yong Oh, Kwang Won Seo, Yangjin Jegal, Jong-Joon Ahn, Young Joo Min, Chang Ryul Park, Jae Cheol Hwang
Korean J Intern Med. 2013;28(5):622-625. Published online August 14, 2013
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Gastroenterology / Original Article
Factors influencing hepatocellular carcinoma prognosis after hepatectomy: a single-center experience
Sung Keun Park, Young Kul Jung, Dong Hae Chung, Keon Kuk Kim, Yeon Ho Park, Jung Nam Lee, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim
Korean J Intern Med. 2013;28(4):428-438. Published online July 1, 2013
Background/AimsRecurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in pati..
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Review
Status Quo of Chronic Liver Diseases, Including Hepatocellular Carcinoma, in Mongolia
Amarsanaa Jazag, Natsagnyam Puntsagdulam, Jigjidsuren Chinburen
Korean J Intern Med. 2012;27(2):121-127. Published online May 31, 2012
Because Mongolia has much higher liver disease burden than any other regions of the world, it is necessary to provide information on real-time situation of chronic liver disease in Mongolia. In this article, we reviewed studies performed in Mongolia from 2000 to 2011 on seroprevalence of hepatiti..
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Original Article
Risk Factors of Cryptogenic Hepatocellular Carcinoma in Patients with Low Body Mass Index or without Metabolic Syndrome
Hwa Young Song, Hyo Keun Lee, June Sung Lee, Jong Yeon Kim, Yun Hyuk Yim, Tae Jun Song, Won Ki Bae, Nam-Hoon Kim, Kyung-Ah Kim
Korean J Intern Med. 2012;27(1):47-52. Published online February 28, 2012
Background/AimsMany patients are diagnosed with cryptogenic hepatocellular carcinoma (HCC) without metabolic syndrome (MS). We investigated the risk factors for cryptogenic HCC in patients with a low body mass index (BMI) or without MS. MethodsT..
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Review
Molecular Epidemiology of Hepatitis B Virus
Jia-Horng Kao
Korean J Intern Med. 2011;26(3):255-261. Published online September 13, 2011
Although safe and effective vaccines for hepatitis B virus (HBV) have been available for nearly three decades, this virus kills at least 600,000 people annually worldwide and remains the leading global cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Because the HBV reverse tr..
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Case Report
Application of Helical Tomotherapy for Two Cases of Advanced Hepatocellular Carcinoma
Joon Sung Kim, Chan Ran You, Jeong Won Jang, Si-Hyun Bae, Jong Yong Choi, Seung Kew Yoon, Chul Seung Kay
Korean J Intern Med. 2011;26(2):201-206. Published online June 1, 2011
The role of radiotherapy in the treatment of hepatocellular carcinoma (HCC) has been limited to date, because the liver has a low tolerance to radiation. However, reconstructing tumors and surrounding organs via a three-dimensional conformal planning system can avoid excess radiotherapy exposure ..
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Case Report
Successful Treatment of Stereotactic Body Radiation Therapy Combined with Transarterial Chemolipiodolization for Hepatocellular Carcinoma with Biliary Obstruction
Chan-Kwon Park, Si-Hyun Bae, Hong-Jun Yang, Ho-Jong Chun, Il-Bong Choi, Jong-Young Choi, Seung-Kew Yoon
Korean J Intern Med. 2011;26(1):94-98. Published online March 2, 2011
Conventional radiation therapy (RT) is a widely recognized treatment for hepatocellular carcinoma (HCC). However, conventional RT plays only a limited role in HCC treatment because of its low efficacy and the low tolerance of the liver for this modality. Stereotactic body radiation therapy (SBRT)..
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Case Report
A Case of Hepatocellular Carcinoma Within Hepatocellular Adenoma in a Non-Cirrhotic Male
Dong Hwan Kim, Seung Up Kim, Dong Hyuk Nam, Yoon Jung Choi, Soo Mi Park, Chon Kyun Lee, Do Young Kim
Korean J Intern Med. 2009;24(2):147-152. Published online June 8, 2009
Hepatocellular adenoma (HA) is a benign hepatic lesion that predominantly occurs in young women. Most hepatocellular carcinomas (HCC) arise in a cirrhotic liver during the fifth or sixth decades. There have been several reported cases of HCC developing from HA in female patients. However, there a..
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