|
Gastroenterology / Original Article
Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Korean J Intern Med. 2020;35(1):65-78. Published online June 17, 2019
Background/Aims: We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea.
Methods: A total of 447 consecutive treatment-naïve NBNC-HCC adult patients who were r..
|
|
|
Review
Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome
Hajeong Lee, Eunjeong Kang, Hee Gyung Kang, Young Hoon Kim, Jin Seok Kim, Hee-Jin Kim, Kyung Chul Moon, Tae Hyun Ban, Se Won Oh, Sang Kyung Jo, Heeyeon Cho, Bum Soon Choi, Junshik Hong, Hae Il Cheong, Doyeun Oh
Korean J Intern Med. 2020;35(1):25-40. Published online January 2, 2020
Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of endothelial cell damage, as well as the resulting ischemic end-organ injuries. A variety of clinical scenarios have features of ..
|
|
|
Rheumatology / Original Article
Standardized, musculoskeletal ultrasonographic reference values for healthy Korean adults
Hyun-Sook Kim, Hae-Rim Kim, Bo Young Kim, Yun Sung Kim, Young Ok Jung, Sung Jae Choi, Hyun-Ok Kim, Jiwon Hwang, Sunggun Lee, Hyoun-Ah Kim, So Young Bang, Ji-Young Chai, Sung-Hoon Park, Chong-Hyeon Yoon
Korean J Intern Med. 2019;34(6):1372-1380. Published online May 4, 2018
Background/Aims: To define standard reference values for musculoskeletal ultrasonography (MSUS) in Korea.
Methods: A total of 251 healthy adults were recruited for this study. Ultrasonography was performed by experienced rheumatologists who had undergone four appropriate training programs in Korea..
|
|
|
Hemato-oncology / Original Article
The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis
Hyera Kim, Kang Kook Lee, Mi Hwa Heo, Jin Young Kim
Korean J Intern Med. 2019;34(6):1324-1332. Published online October 26, 2018
Background/Aims: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of canc..
|
|
|
Endocrinology-metabolism / Original Article
Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Korean J Intern Med. 2019;34(6):1287-1296. Published online March 13, 2018
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.
Methods: We retrospectively review..
|
|
|
Gastroenterology / Original Article
Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Korean J Intern Med. 2019;34(6):1223-1232. Published online October 26, 2018
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods: This study analyzed 175 conse..
|
|
|
Review
Rheumatic complications in cancer patients treated with immune checkpoint inhibitors
Kyung-Ann Lee, Hae-Rim Kim, So Young Yoon
Korean J Intern Med. 2019;34(6):1197-1209. Published online April 25, 2019
Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-..
|
|
|
Hemato-oncology / Original Article
Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial
Ho-Young Yhim, Won-Il Choi, Sung-Hyun Kim, Seung-Hyun Nam, Kyoung Ha Kim, Yeung-Chul Mun, Doyeun Oh, Hun-Gyu Hwang, Keun-Wook Lee, Eun-Kee Song, Yong Shik Kwon, Soo-Mee Bang
Korean J Intern Med. 2019;34(5):1125-1135. Published online May 23, 2018
Background/Aims: Limited data are available regarding the efficacy of rivaroxaban for the treatment of cancer-associated venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of rivaroxaban for the treatment of VTE in active cancer patients.
Methods: In th..
|
|
|
Hemato-oncology / Original Article
Efficacy and safety of cisplatin and weekly docetaxel in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
Moon Jin Kim, Sung Min Kim, Hyun Ae Jung, Jung Yong Hong, Won Jin Chang, Moon Ki Choi, Hye Sook Kim, Jong-Mu Sun, Keunchil Park, Myung-Ju Ahn
Korean J Intern Med. 2019;34(5):1107-1115. Published online June 20, 2018
Background/Aims: We investigated the efficacy and toxicity of a weekly schedule of docetaxel and cisplatin as a first-line treatment in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC).
Methods: In this study, 18 patients with previously diagnosed R/M HNSCC we..
|
|
|
Hemato-oncology / Original Article
Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Ji-Yeon Kim, Jin-Seok Ahn, Young-Hyuck Im, Yeon Hee Park
Korean J Intern Med. 2019;34(5):1100-1106. Published online March 16, 2018
Background/Aims: We conducted a retrospective analysis of the clinical activity of fulvestrant in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) previously treated with endocrine therapy and/or chemotherapy..
|
|
|
Nephrology / Original Article
Clinical outcomes and effects of treatment in older patients with idiopathic membranous nephropathy
Yaeni Kim, Hye Eun Yoon, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Yu Ah Hong, Suk Young Kim, Yoon-Kyung Chang, Hyeon Seok Hwang
Korean J Intern Med. 2019;34(5):1091-1099. Published online August 14, 2019
Background/Aims: Membranous nephropathy (MN) is the most common primary glomerular disease diagnosed in older patients. Few reports describe the clinical outcomes in older patients with idiopathic MN.
Methods: The outcomes of 135 patients with histologically proven MN were analyzed. ‘Older’ was ..
|
|
|
Pulmonology / Original Article
Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment
Tae-Ok Kim, Hong-Joon Shin, Yu-Il Kim, Sung-Chul Lim, Young-Il Koh, Yong-Soo Kwon
Korean J Intern Med. 2019;34(5):1050-1057. Published online March 19, 2019
Background/Aims: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients undergoing anti-TB treatment.
Methods: We retrospecti..
|
|
|
Cardiology / Original Article
Clinical characteristics and outcomes in acute myocardial infarction patients with versus without any cardiovascular risk factors
Ah-Ra Choi, Myung Ho Jeong, Young Joon Hong, Seok-Joon Sohn, Hyun Yi Kook, Doo Sun Sim, Young Keun Ahn, Ki Hong Lee, Jae Yeong Cho, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim; other Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2019;34(5):1040-1049. Published online September 1, 2018
Background/Aims: Although cardiovascular (CV) risk factors are well established, some patients experience acute myocardial infarction (AMI) even without any risk factors.
Methods: We analyzed total 11,390 patients (63.6 ± 12.6 years old, 8,401 males) with AMI enrolled in Korea Acute Myocardial In..
|
|
|
Gastroenterology / Original Article
Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2019;34(5):1022-1029. Published online June 14, 2018
Background/Aims: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect t..
|
|
|
Gastroenterology / Original Article
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis
Ki-Nam Shim, Jin Il Kim, Nayoung Kim, Sang Gyun Kim, Yun Ju Jo, Su Jin Hong, Jeong Eun Shin, Gwang Ha Kim, Kyung Sik Park, Suck Chei Choi, Joong Goo Kwon, Jie-Hyun Kim, Hyun Jin Kim, Ji Won Kim
Korean J Intern Med. 2019;34(5):1008-1021. Published online June 1, 2018
Background/Aims: Irsogladine maleate, an enhancer of gastric mucosal protective factors, has demonstrated its efficacy for various gastric mucosal injuries. The aim of this study was to evaluate the efficacy and safety of irsogladine for prevention of nonsteroidal anti-inflammatory drugs (NSAIDs) or..
|
|
|
Gastroenterology / Original Article
Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Korean J Intern Med. 2019;34(5):998-1007. Published online May 31, 2018
Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma.
Methods: A cross-sectional st..
|
|
|
Review
Cellular immunotherapy in multiple myeloma
Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Duck Cho, Hye-Seong Park, Tan-Huy Chu, Hyun-Ju Lee, Hyeoung-Joon Kim, Sang-Ki Kim, Je-Jung Lee
Korean J Intern Med. 2019;34(5):954-965. Published online February 15, 2019
In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic..
|
|
|
Rheumatology / Original Article
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung; Korean Observational Study Network for Arthritis (KORONA) Investigators
Korean J Intern Med. 2019;34(4):910-916. Published online December 15, 2017
Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA).
Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in t..
|
|
|
Hemato-oncology / Original Article
Clinical significance of rituximab infusion-related reaction in diffuse large B-cell lymphoma patients receiving R-CHOP
Kyoung Min Cho, Bhumsuk Keam, Hyerim Ha, Miso Kim, Jae-Woo Jung, Woo-Jung Song, Tae Min Kim, Yoon Kyung Jeon, Hye-Ryun Kang, Dong-Wan Kim, Chul Woo Kim, Dae Seog Heo
Korean J Intern Med. 2019;34(4):885-893. Published online November 20, 2017
Background/Aims: This study was to evaluate the clinical significance of infusion-related reaction (IRR) of rituximab in diffuse large B-cell lymphoma (DLBCL) patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) as a first-line chemotherapy.
Methods..
|
|
|
Endocrinology-metabolism / Original Article
Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity
Hye Jeong Kim, Mi Kyung Kwak, In Ho Choi, So-Young Jin, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
Korean J Intern Med. 2019;34(4):850-857. Published online February 23, 2018
Background/Aims: The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules.
Methods: One ..
|
|
|
