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Original Article
Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome
Yeo Kyung Lee, Jo Eun Kim, Hyun Ju Oh, Kyung Sun Park, Soo Kyung Kim, Seok Won Park, Moon Jong Kim, Yong Wook Cho
Korean J Intern Med. 2011;26(4):432-439. Published online November 28, 2011
Background/AimsThe proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study..
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Original Article
Gender Differences in Susceptibility to Smoking among Patients with Lung Cancer
Jeong-Seon Ryu, Sang-Hoon Jeon, Jung-Soo Kim, Jung Hwan Lee, Seong Hyun Kim, Ji Taek Hong, Ju Hong Jeong, Ji Joong Jeong, Myung Dong Lee, Sang Joon Min, Hae-Seong Nam, Jae-Hwa Cho, Seung-Min Kwak, Hong Lyeol Lee, Hyun-Jung Kim
Korean J Intern Med. 2011;26(4):427-431. Published online November 28, 2011
Background/AimsTo determine whether female smokers are more or less susceptible to the detrimental pulmonary-function effects of smoking when compared to male smokers among patients with lung cancer. MethodsPack-years and pulmonary function indi..
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Original Article
Sound Analysis in an In Vitro Endotracheal Tube Model
Young Sik Park, Young Wook Kee, Kwang Suk Park, Jinwoo Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Seok-Chul Yang
Korean J Intern Med. 2011;26(4):421-426. Published online November 28, 2011
Background/AimsComplete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to the lack of proper detection methods. We tested w..
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Original Article
Alteration of Left Ventricular Function with Dobutamine Challenge in Patients with Myocardial Bridge
Joon-Hyung Jhi, Kyoung-Im Cho, Jong-kun Ha, Chan-Woo Jung, Bong-Jae kim, Seong-Oh Park, A-Ra Jo, Seong-Man Kim, Hyeon-Gook Lee, Tae-Ik Kim
Korean J Intern Med. 2011;26(4):410-420. Published online November 28, 2011
Background/AimsThe aim of this study was to identify changes in left ventricular (LV) performance in patients with a myocardial bridge (MB) in the left anterior descending coronary artery during resting and in an inotropic state. MethodsMyocardi..
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Original Article
A Combination of Melphalan, Prednisone, and 50 mg Thalidomide Treatment in Non-Transplant-Candidate Patients with Newly Diagnosed Multiple Myeloma
Hye Jung Chang, Jae Hoon Lee, Young Rok Do, Sung-Hwa Bae, Jung-Lim Lee, Seung Hyun Nam, Sung-Soo Yoon, Soo-Mee Bang
Korean J Intern Med. 2011;26(4):403-409. Published online November 28, 2011
Background/AimsThe clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as a first-line treatment. Because the side effects of thalidomid..
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Review
Endoscopic Therapy in Chronic Pancreatitis
Damien Meng Yew Tan, Stuart Sherman
Korean J Intern Med. 2011;26(4):384-399. Published online November 28, 2011
Chronic pancreatitis (CP) is a debilitating disease that can result in chronic abdominal pain, malnutrition, and other related complications. The main aims of treatment are to control symptoms, prevent disease progression, and correct any complications. A multidisciplinary approach involving medi..
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Review
Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic
Jae Youn Cho
Korean J Intern Med. 2011;26(4):367-383. Published online November 28, 2011
Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in asthma, including transforming growth factor-β, interleukin (IL)-5, basic fib..
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Case Report
Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes
Osman Sener, Ösman Kose, Özgür Kartal, Mukerrem Safali
Korean J Intern Med. 2011;26(3):360-363. Published online September 13, 2011
Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents ..
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Case Report
Topical Steroids to Treat Granulomatous Mastitis: A Case Report
Fatih Altintoprak
Korean J Intern Med. 2011;26(3):356-359. Published online September 13, 2011
Idiopathic granulomatous mastitis (IGM) is a rare and chronic benign disease of the breast. Histologically, the disease presents as an intense inflammatory reaction with non-caseated granulomas that are the characteristic symptom of the disease. No consensus exists on the best treatment modality ..
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Case Report
Transcatheter Arterial Embolization as Treatment for a Life-Threatening Retroperitoneal Hemorrhage Complicating Heparin Therapy
Sang-Ho Park, Se-Whan Lee, Ung Jeon, Min-Hyeok Jeon, Seung-Jin Lee, Won-Yong Shin, Dong-Kyu Jin
Korean J Intern Med. 2011;26(3):352-355. Published online September 13, 2011
Spontaneous retroperitoneal hemorrhage is a distinct clinical entity that can present in the absence of specific underlying pathology or trauma and is typically associated with anticoagulation therapy. We report a case of a 74-year-old female patient with a cerebral infarction related to atrial f..
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Case Report
Primary Adenosquamous Cell Carcinoma of the Pancreas: A Case Report with a Review of the Korean Literature
Youn Ju Na, Ki-Nam Shim, Min Sun Cho, Sun Hee Sung, Sung-Ae Jung, Kwon Yoo, Kyu Won Chung
Korean J Intern Med. 2011;26(3):348-351. Published online September 13, 2011
The most common pancreatic cancer is adenocarcinoma. Primary adenosquamous cell carcinoma of the pancreas is very rare and aggressive. A 46-year-old man presented with a 3-month history of dyspepsia and a 7-kg weight loss. The physical examination showed tenderness of the right upper quadrant of..
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Original Article
Efficacy and Safety of Monthly 150 mg Oral Ibandronate in Women with Postmenopausal Osteoporosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Young Ho Lee, Gwan Gyu Song
Korean J Intern Med. 2011;26(3):340-347. Published online September 13, 2011
Background/AimsThe aim of this study was to assess the efficacy and safety of monthly oral 150 mg ibandronate in women with postmenopausal osteoporosis (PMO). MethodsA systematic review and meta-analysis were performed to determine treatment eff..
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Original Article
Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience
Dong-Yeop Shin, Inho Kim, Ki-Hwan Kim, Younak Choi, Seung Hoon Beom, Yaewon Yang, Yoojoo Lim, Eunyoung Lee, June Koo Lee, Ji Yeon Kim, Hyun Kyung Kim, Sung-Soo Yoon, Dong Soon Lee, Seonyang Park, Byoung-Kook Kim
Korean J Intern Med. 2011;26(3):328-339. Published online September 13, 2011
Background/AimsWe investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). MethodsWe reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of el..
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Original Article
Effects of Lowering Dialysate Calcium Concentrations on Arterial Stiffness in Patients Undergoing Hemodialysis
Jwa-Kyung Kim, Sung Jin Moon, Hyeong Cheon Park, Jae Sung Lee, Soung Rok Sim, Sung Chang Bae, Sung Kyu Ha
Korean J Intern Med. 2011;26(3):320-327. Published online September 13, 2011
Background/AimsWe assessed changes in hemodynamic and arterial stiffness parameters following reductions of dialysate calcium concentrations in patients undergoing hemodialysis. MethodsIn this prospective study, 20 patients on maintenance hemodi..
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Original Article
Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells
Youn Joo Jeon, Yong Soo Kim
Korean J Intern Med. 2011;26(3):314-319. Published online September 13, 2011
Background/AimsHypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. MethodsHuh7 cells were incubate..
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Original Article
Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
Young Sun Kim, Hye Lim Lee, Ki Bum Lee, Joo Hun Park, Wou Young Chung, Keu Sung Lee, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang
Korean J Intern Med. 2011;26(3):304-313. Published online September 13, 2011
Background/AimsOxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2) binds to antioxidant responsive elements..
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Original Article
Comparison of Clinical Outcomes of Hydrophilic and Lipophilic Statins in Patients with Acute Myocardial Infarction
Min Chul Kim, Youngkeun Ahn, Su Young Jang, Kyung Hoon Cho, Seung Hwan Hwang, Min Goo Lee, Jum Suk Ko, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Yoon, Kye Hun Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2011;26(3):294-303. Published online September 13, 2011
Background/AimsA controversy exists about which statin is preferable for patients with acute myocardial infarction (AMI), and clinical impacts of different statins according to lipophilicity have not been established. MethodsThe 1,124 patients w..
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Original Article
Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
Sang Soo Kim, Jeong Gyu Lee, Dong Wok Kim, Bo Hyun Kim, Yun Kyung Jeon, Mi Ra Kim, Jeong Eun Huh, Ji Young Mok, Seong-Jang Kim, Yong Ki Kim, In Joo Kim
Korean J Intern Med. 2011;26(3):285-293. Published online September 13, 2011
Background/AimsThe objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status. MethodsThe study included 4,125 consecutive Korean subjects (30-79 ..
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Original Article
Sleep Disorder and Cardiovascular Risk Factors among Patients with Type 2 Diabetes Mellitus
Unjin Shim, Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung
Korean J Intern Med. 2011;26(3):277-284. Published online September 13, 2011
Background/AimsSleep disorder (SD) is associated with an increased risk of cardiovascular disease and is more prevalent among individuals with type 2 diabetes mellitus. These health problems not only frequently coexist but also exacerbate each other. We conducted a cross-secti..
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Review
Impact of Air Pollution on Allergic Diseases
Hajime Takizawa
Korean J Intern Med. 2011;26(3):262-273. Published online September 13, 2011
The incidence of allergic diseases in most industrialized countries has increased. Although the exact mechanisms behind this rapid increase in prevalence remain uncertain, a variety of air pollutants have been attracting attention as one causative factor. Epidemiological and toxicological researc..
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