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Pulmonology / Original Article
Prognostic significance of malnutrition for long-term mortality in community-acquired
pneumonia: a propensity score matched analysis
Hye Ju Yeo, Ki Sup Byun, Junhee Han, June Hyun Kim, Seung Eun Lee, Seong Hoon Yoon, Doosoo Jeon, Yun Seong Kim, Woo Hyun Cho
Korean J Intern Med. 2019;34(4):841-849. Published online January 29, 2019
Background/Aims: The impact of malnutrition on the outcome of hospitalized adults with community-acquired pneumonia (CAP) has not been fully investigated. This study evaluated the prevalence and prognostic significance of malnutrition in a Korean population with CAP. Methods: In total, 198 patients ..
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Pulmonology / Original Article
Birt-Hogg-Dubé syndrome in Korean: clinicoradiologic features and long term follow-up
Joo Hee Lee, Min Joo Jeon, Joon Seon Song, Eun Jin Chae, Jin-Ho Choi, Gu-Hwan Kim, Jin Woo Song
Korean J Intern Med. 2019;34(4):830-840. Published online October 26, 2018
Background/Aims: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder that is characterized by skin fibrofolliculomas, pulmonary cysts, and renal tumors. The objective of this study was to describe the features of Korean patients with BHD syndrome.
Methods: Clinical data were retro..
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Cardiology / Original Article
Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions
Wonsuk Choi, In-Ho Chae, Jin Joo Park, Sun-Hwa Kim, Si-Hyuck Kang, Il-Young Oh, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, Dong-Ju Choi
Korean J Intern Med. 2019;34(4):819-829. Published online July 4, 2018
Background/Aims: After a study comparing drug-eluting stents (DESs) to sequential treatment with drug-eluting balloons (DEBs) and bare metal stents (BMSs), we retrospectively analysed strut malapposition and neointimal hyperplasia in de novo coronary lesions using optical coherence tomography (OCT) ..
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Gastroenterology / Original Article
Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice
Jeong Eun Song, Chang Hyeong Lee, Byung Seok Kim
Korean J Intern Med. 2019;34(4):802-810. Published online April 8, 2019
Background/Aims: The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed to evaluate the long-term efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF therapy in..
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Gastroenterology / Original Article
Daclatasvir and asunaprevir combination therapy for patients with chronic hepatitis C virus genotype 1b infection in real world
Jae Young Oh, Byung Seok Kim, Chang Hyeong Lee, Jeong Eun Song, Heon Ju Lee, Jung Gil Park, Jae Seok Hwang, Woo Jin Chung, Byoung Kuk Jang, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Sang Gyu Kwak
Korean J Intern Med. 2019;34(4):794-801. Published online May 25, 2018
Background/Aims: Previous studies have reported a high rate of sustained virologic response (SVR) and a low rate of serious adverse events with the use of daclatasvir (DCV) and asunaprevir (ASV) combination therapy. We evaluated the efficacy and safety of DCV and ASV combination therapy for patient..
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Gastroenterology / Original Article
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019;34(4):777-784. Published online February 23, 2018
Background/Aims: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mon..
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Review
Current status of pulmonary arterial hypertension in Korea
Albert Youngwoo Jang, Wook-Jin Chung
Korean J Intern Med. 2019;34(4):696-707. Published online July 1, 2019
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the distal pulmonary arteries resulting in high pulmonary vascular resistance and, eventually, right ventricular heart failure. Although current advances in PAH therapy have improved outcomes, poor survival remains a reality wor..
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Rheumatology / Original Article
Magnetic resonance imaging-assessed synovial and bone changes in hand and wrist joints of rheumatoid arthritis patients
Kyung-Ann Lee, Sang-Ho Min, Tae-Hyung Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2019;34(3):651-659. Published online November 24, 2017
Background/Aims: Magnetic resonance imaging (MRI) is a sensitive and useful method for the detection of synovitis and joint destruction in rheumatoid arthritis (RA) patients. However, the patterns of MRI-detected bone erosion, bone marrow edema (BME), synovitis, and tenosynovitis have received insuf..
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Allergy / Original Article
Prevalence of anaphylaxis and prescription rates of epinephrine auto-injectors in urban and rural areas of Korea
Hyunseok Cho, Jae-Woo Kwon
Korean J Intern Med. 2019;34(3):643-650. Published online October 26, 2018
Background/Aims: Despite the clinical importance anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis, risk factors for anaphylaxis, and epinephrine auto-injector (EAI) prescription status for patients with anaphylaxis remain poorly described. Thus..
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Cardiology / Original Article
Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
Min Chul Kim, Kye Hun Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2019;34(3):549-558. Published online March 23, 2018
Background/Aims: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF).
Methods: A total of 384 surviving patients with acute ..
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Infectious diseases / Original Article
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Korean J Intern Med. 2019;34(2):409-417. Published online October 12, 2017
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients ..
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Hemato-oncology / Original Article
Prognostic role of beclin-1 in locally advanced non-small cell lung cancer in patients receiving docetaxel-platinum induction chemotherapy
Hee Yeon Lee, Jung Ha Shin, Kyo-Young Lee, Jae Kil Park, Sook Whan Sung, Yeon Sil Kim, Jin-Hyoung Kang, Jeong-Oh Kim
Korean J Intern Med. 2019;34(2):401-408. Published online September 6, 2018
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemotherapy (IC) yielding conflicting results. This study aimed to assess the clinicopathologic and prognostic significance of the excision repair cross-com..
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Hemato-oncology / Original Article
Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia
Chul Hee Kim, Yoon Seok Choi, Ji Young Moon, Duck Yong Kim, So Yeon Lee, Hyo Jin Lee, Hwan Jung Yun, Samyong Kim, Deog Yeon Jo, Ik Chan Song
Korean J Intern Med. 2019;34(2):383-389. Published online November 27, 2017
Background/Aims: Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use.
Methods: We retrospectively compared platelet responses and toxicities associated with these two treatments in..
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Nephrology / Original Article
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus
In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2019;34(2):365-374. Published online December 13, 2017
Background/Aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM).
Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subc..
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Endocrinology-metabolism / Original Article
Non-fasting triglyceride levels in the Korean population with and without ischemic heart disease and cerebrovascular disease
Seo Young Lee, Bo Kyung Koo, Min Kyong Moon
Korean J Intern Med. 2019;34(2):353-364. Published online November 15, 2017
Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans.
Methods: We conduc..
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Pulmonology / Original Article
Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study
Hyeonseok Kim, Jeong Ha Mok, Bohyoung Kang, Taehoon Lee, Hyun-Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Korean J Intern Med. 2019;34(2):344-352. Published online July 27, 2018
Background/Aims: This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea.
Methods: We retrospectively reviewed the drug susceptibility testing results of c..
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Cardiology / Original Article
A score for decision making during percutaneous coronary intervention in acute myocardial infarction patients with multivessel disease
Hae Chang Jeong, Joon Ho Ahn, Min Chul Kim, Doo Sun Sim, Keun Ho Park, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Ki-Bae Seung, Kiyuk Chang, Youngkeun Ahn
Korean J Intern Med. 2019;34(2):324-334. Published online March 20, 2018
Background/Aims: The optimal percutaneous coronary intervention (PCI) strategy in patients with acute myocardial infarction (AMI) with multivessel disease (MVD) is uncertain. This study was designed to develop a novel and simple tool for assessing an individualized and optimized PCI strategy in AMI ..
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Gastroenterology / Original Article
Clinical features of snoring patients during sedative endoscopy
Jung Wha Chung, Nayoung Kim, Jee Hye Wee, Jaebong Lee, Jongchan Lee, Soohoon Kwon, Young-Jae Hwang, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Jin-Wook Kim
Korean J Intern Med. 2019;34(2):305-314. Published online November 15, 2017
Background/Aims: Snoring is the sound of turbulence and vibration of the upper respiratory tissues and has been identified as a risk factor of obstructive sleep apnea (OSA) and cardiovascular disease. The aim of this study was to identify associated clinical factors in snoring patients undergoing se..
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Gastroenterology / Original Article
Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis
Hyo Young Lee, Dae Won Jun, Hyun Jung Kim, Hyunwoo Oh, Waqar Khalid Saeed, Hyeongsik Ahn, Ramsey C. Cheung, Mindie H. Nguyen
Korean J Intern Med. 2019;34(2):296-304. Published online March 20, 2018
Background/Aims: A number of clinical trials reported varying effects of cholesterol lowering agents in nonalcoholic fatty liver disease (NAFLD) patients. We, therefore, assessed the changes in hepatic steatosis and NAFLD activity score (NAS) after treatment with cholesterol lowering agents in NAFLD..
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Cardiology / Review
Chronic venous insufficiency and varicose veins of the lower extremities
Young Jin Youn, Juyong Lee
Korean J Intern Med. 2019;34(2):269-283. Published online October 26, 2018
Chronic venous insufficiency (CVI) of the lower extremities manifests itself in various clinical spectrums, ranging from asymptomatic but cosmetic problems to severe symptoms, such as venous ulcer. CVI is a relatively common medical problem but is often overlooked by healthcare providers because of ..
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