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Nephrology / Original Article
Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Nephrology / Original Article
Tumor necrosis factor α is a risk factor for infection in peritoneal dialysis patients
Eunjung Kang, Seihran Kim, Hwa Jung Lee, Inhwee Park, Heungsoo Kim, Gyu-Tae Shin
Korean J Intern Med. 2016;31(4):722-729. Published online March 22, 2016
Background/Aims: It has been shown that circulating tumor necrosis factor α (TNF-α) is elevated in end stage renal disease patients; however, the relationship between TNF-α and the development of infection in these patients is unknown. In this study, we investigated the association of plasma TNF-..
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Pulmonology / Original Article
Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment
response
Sung-Jin Nam, Jee-Yeong Jeong, Tae-Won Jang, Mann-Hong Jung, Bong-Kwon Chun, Hee-Jae Cha, Chul-Ho Oak
Korean J Intern Med. 2016;31(4):694-702. Published online June 3, 2016
Background/Aims: It is not clear which tests are indicative of the activity and severity of tuberculosis (TB). This study aimed to investigate the predictive value of neuron-specific enolase (NSE) and to determine the origin of NSE in TB patients.
Methods: A single-center retrospective analysis was..
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Rheumatology / Review
Macrophage migration inhibitory factor: a potential therapeutic target for rheumatoid arthritis
Kyoung-Woon Kim, Hae-Rim Kim
Korean J Intern Med. 2016;31(4):634-642. Published online May 12, 2016
Macrophage migration inhibitory factor (MIF) is originally identified in the culture medium of activated T lymphocytes as a soluble factor that inhibits the random migration of macrophages. MIF is now recognized as a multipotent cytokine involved in the regulation of immune and inf lammatory respons..
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Letter to the editor
Occurrence of sarcoidosis after chemotherapy for non-Hodgkin lymphoma
Hyungwoo Cho, Dok Hyun Yoon, Jwa Hoon Kim, Young Bo Ko, Byoung Soo Kwon, In-Hye Song, Cheolwon Suh
Korean J Intern Med. 2016;31(3):605-607. Published online March 12, 2016
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Letter to the editor
Cyclophosphamide therapy for secondary amyloidosis in a patient with juvenile idiopathic arthritis unresponsive to tumor necrosis factor α inhibitor therapy
Sun Ae Han, Young Min Yoon, Wan Soo Lee, Yun Sung Kim, Byung Chul Shin, Jong Hoon Chung, Hyun Lee Kim
Korean J Intern Med. 2016;31(3):601-604. Published online March 7, 2016
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Hemato-oncology / Original Article
Treatment outcomes and clinical relevance of the
Follicular Lymphoma International Prognostic Index in Korean follicular lymphoma patients
treated with chemotherapy
Chi Hoon Maeng, Sung Woo Ahn, Seong-Yoon Ryu, Sungjun Han, Young Hyeh Ko, Jun Ho Ji, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2016;31(3):560-569. Published online February 22, 2016
Background/Aims: The Follicular Lymphoma International Prognostic Index (FLIPI) and FLIPI2 are well-known prognostic models for patients with follicular lymphoma (FL). However, their prognostic relevance has not been examined before in Korean patients with FL.
Methods: We reviewed clinical and labo..
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Nephrology / Original Article
Comparison of treatment delay associated with tunneled hemodialysis catheter placement between interventionists
Yoo Hyung Kim, Hae Ri Kim, Hong Jae Jeon, Ye-Jin Kim, Sa Ra Jung, Dae Eun Choi, Kang Wook Lee, Ki Ryang Na
Korean J Intern Med. 2016;31(3):543-551. Published online April 14, 2016
Background/Aims: Fragmented care in nephrology can cause treatment delays. Nephrologists are qualified to perform vascular access-related procedures because they understand the pathophysiology of renal disease and perform physical examination for vascular access. We compared treatment delays associa..
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Cardiology / Original Article
Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy
Jung-Hee Lee, Jae-Sun Uhm, Dong Geum Shin, Boyoung Joung, Hui-Nam Pak, Young-Guk Ko, Geu-Ru Hong, Moon-Hyoung Lee
Korean J Intern Med. 2016;31(3):507-516. Published online April 7, 2016
Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations.
Methods: We investigated a total of 128 pati..
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Gastroenterology / Original Article
Clinical outcome of acute nonvariceal upper gastrointestinal bleeding after hours: the role of urgent endoscopy
Dong-Won Ahn, Young Soo Park, Sang Hyub Lee, Cheol Min Shin, Jin-Hyeok Hwang, Jin-Wook Kim, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee
Korean J Intern Med. 2016;31(3):470-478. Published online April 6, 2016
Background/Aims: This study was performed to investigate the clinical role of urgent esophagogastroduodenoscopy (EGD) for acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) performed by experienced endoscopists after hours.
Methods: A retrospective analysis was performed for consecutively ..
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Gastroenterology / Original Article
Comparison of enhancement and image quality: different iodine concentrations for liver on 128-slice multidetector computed tomography in the same chronic liver disease patients
Byoung Goo Jo, Yun Gyu Song, Sang Goon Shim, Young Wook Kim
Korean J Intern Med. 2016;31(3):461-469. Published online December 23, 2015
Background/Aims: The objective of this study was to compare the degree of hepatic enhancement and image quality using contrast media of different iodine concentrations with the same iodine dose.
Methods: From July 2011 to June 2013, 50 patients with chronic liver disease who underwent baseline and ..
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Gastroenterology / Review
Functional dyspepsia: new insights into pathogenesis and therapy
Nicholas J. Talley
Korean J Intern Med. 2016;31(3):444-456. Published online April 6, 2016
One in 10 people suffer from functional dyspepsia (FD), a clinical syndrome comprising chronic bothersome early satiety, or postprandial fullness, or epigastric pain or burning. Postprandial distress syndrome (PDS, comprising early satiety and/or postprandial fullness) and epigastric pain syndrome (..
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Hemato-oncology / Review
Chronic lymphocytic leukemia: a clinical review including Korean cohorts
Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2016;31(3):433-443. Published online April 5, 2016
Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterizati..
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Letter to the editor
Mixed-phenotype acute leukemia treated with decitabine
Ji-Young Lee, Sang-min Lee, Ja-Young Lee, Ki-Hyang Kim, Moon-Young Choi, Won-Sik Lee
Korean J Intern Med. 2016;31(2):406-408. Published online February 15, 2016
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Letter to the editor
Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis
A Young Cho, Byeong Gwan Kim, Sang Sun Kim, Seong Hee Lee, Hong Shik Shin, Yeong Jin Choi, In O Sun
Korean J Intern Med. 2016;31(2):403-405. Published online February 11, 2016
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Rheumatology / Original Article
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Adem Kucuk, Mehmet Fatih Erol, Soner Senel, Emir Eroler, Havvanur Alparslan Yumun, Ali Ugur Uslu, Asiye Mukaddes Erol, Deniz Tihan, Ugur Duman, Tevfik Kucukkartallar, Yalcin Solak
Korean J Intern Med. 2016;31(2):386-391. Published online February 11, 2016
Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lym..
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Allergy / Original Article
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Nephrology / Original Article
Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Young-Il Jo, Ha-Young Na, Ju-Young Moon, Sang-Woong Han, Dong-Ho Yang, Sang-Ho Lee, Hyeong-Cheon Park, Hoon-Young Choi, So-Dug Lim, Jeong-Hae Kie, Yong-Kyu Lee, Sug-Kyun Shin
Korean J Intern Med. 2016;31(2):335-343. Published online February 15, 2016
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normo..
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Endocrinology-metabolism / Original Article
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2016;31(2):313-322. Published online December 23, 2015
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer.
Methods: All 2D data were interpreted in real time and 3D data were sto..
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Cardiology / Original Article
Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
Hae-Young Lee, Wook-Jin Chung, Hui-Kyung Jeon, Hong-Seog Seo, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Joon Han Shin, Seok-Min Kang, Sung Cil Lim, Sang-Hong Baek
Korean J Intern Med. 2016;31(2):277-287. Published online February 16, 2016
Background/Aims: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).
Methods: One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled ..
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