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Rheumatology / Original Article
Impact of early diagnosis on functional disability in rheumatoid arthritis
Dam Kim, Chan-Bum Choi, Jiyoung Lee, Soo-Kyung Cho, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Sung Won Lee, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Yoon-Kyoung Sung, Sang-Cheol Bae; KORONA investigators
Korean J Intern Med. 2017;32(4):738-746. Published online September 13, 2016
Background/Aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients.
Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined earl..
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Hemato-oncology / Original Article
Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma
Dae Sik Kim, Eun Sang Yu, Ka-Won Kang, Se Ryeon Lee, Yong Park, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim
Korean J Intern Med. 2017;32(4):711-721. Published online November 4, 2016
Background/Aims: The aims of this study were to identify the value of inflammatory markers as pretreatment prognostic factors for patients with multiple myeloma (MM) and to estimate the value of a prognostic index including these markers at diagnosis.
Methods: A total of 273 newly diagnosed MM pati..
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Endocrinology-metabolism / Review
Metabolically healthy obesity: a friend or foe?
Chang Hee Jung, Woo Je Lee, Kee-Ho Song
Korean J Intern Med. 2017;32(4):611-621. Published online June 5, 2017
Obesity is associated with a reduced life expectancy, largely because obese individuals are at an increased risk of type 2 diabetes, cardiovascular disease, and several types of cancer. Much interest has recently focused on the concept of “all obesity is not created equally.” Obese individuals wi..
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Pulmonology / Review
Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist’s point of view
So-My Koo, Soo-Taek Uh
Korean J Intern Med. 2017;32(4):600-610. Published online June 30, 2017
Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a la..
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Letter to the editor
Successful desensitization of pemetrexed-induced anaphylaxis in a patient with malignant mesothelioma
Jeonghwan Youk, Hyunkyung Park, Kwang Nam Jin, Hyun Jong Moon, Min-Suk Yang, Ki Hwan Kim, Jin-Soo Kim
Korean J Intern Med. 2017;32(3):563-565. Published online November 25, 2016
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Letter to the editor
Lymphoid follicular proctitis resembling rectal carcinoid tumor, confirmed by endoscopic resection
Seungjun Gim, Kang Nyeong Lee, Donghoon Lee, Hye Young Lee, Ki Sul Chang, Oh Young Lee, Ho Soon Choi
Korean J Intern Med. 2017;32(3):548-551. Published online April 18, 2017
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Hemato-oncology / Original Article
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin
Hong-Beum Kim, Jun-Won Seo, Jun-Hyung Lee, Byung-Seok Choi, Sang-Gon Park
Korean J Intern Med. 2017;32(3):523-529. Published online March 30, 2017
Background/Aims: Eosinophilia has numerous diverse causes, and in many patients, it is not possible to establish the cause of eosinophilia. Recently, toxocariasis was introduced as one cause of eosinophilia. The aims of this study were to evaluate the prevalence of toxocariasis and the clinical impa..
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Hemato-oncology / Original Article
KRAS G12C mutation as a poor prognostic marker of pemetrexed treatment in non-small cell lung cancer
Sehhoon Park, Ji-Yeon Kim, Se-Hoon Lee, Beomseok Suh, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2017;32(3):514-522. Published online April 14, 2017
Background/Aims: The predictive and prognostic value of KRAS mutation and its type of mutations in non-small cell lung cancer (NSCLC) are controversial. This clinical study was designed to investigate the predictive value of KRAS mutations and its mutation types to pemetrexed and gemcitabine based t..
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Pulmonology / Original Article
Clinical significance of positive Pneumocystis jirovecii polymerase chain reaction in non-human immunodeficiency virus immunocompromised patients in a real practice
Hea Yon Lee, Hye Seon Kang, Hwa Young Lee, Chin Kook Rhee, Sook Young Lee, Seok Chan Kim, Seung Joon Kim, Yeon Joon Park, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2017;32(3):478-485. Published online December 13, 2016
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised p..
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Cardiology / Original Article
Association between left ventricular function and paraprotein type in patients with multiple
myeloma
Jeong-Eun Yi, Sung-Eun Lee, Hae-Ok Jung, Chang-Ki Min, Ho-Joong Youn
Korean J Intern Med. 2017;32(3):459-468. Published online April 6, 2016
Background/Aims: Multiple myeloma (MM)–associated cardiac damage, particularly according to the type of monoclonal (M) protein has not been elucidated. We sought to investigate relationship between elevated serum M protein levels and echocardiographic indices of cardiac structure and function in pa..
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Gastroenterology / Original Article
Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy
Charles J. Cho, Ho June Song, Gin Hyug Lee, Kee Don Choi, Yong-Hee Kim, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Hwoon-Yong Jung
Korean J Intern Med. 2017;32(3):443-451. Published online March 14, 2016
Background/Aims: Approximately 30% of esophageal cancer (EC) patients cannot complete endoscopic ultrasonography (EUS) due to malignant stricture (EUS non-traversability). This study examines clinical implications of EUS non-traversability in patients with advanced locoregional squamous EC receiving..
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Hemato-oncology / Review
Does the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor differ according to the type of EGFR mutation in non-small cell lung cancer?
Yong Won Choi, Jin-Hyuk Choi
Korean J Intern Med. 2017;32(3):422-428. Published online March 30, 2017
An exon 19 deletion and a L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the two most common mutations that predict favorable efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). Many retrospective and prospective studi..
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Letter to the editor
Everolimus-induced activation of latent Mycobacterium tuberculosis infection in a patient with metastatic renal cell carcinoma
So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee, Eun-Kee Song, Jae-Yong Kwak, Chang-Yeol Yim
Korean J Intern Med. 2017;32(2):365-368. Published online February 2, 2016
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Gastroenterology / Original Article
Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
Su Jong Yu, Jung-Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-Ju Yoo, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Korean J Intern Med. 2017;32(2):261-268. Published online April 5, 2016
Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood m..
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Letter to the editor
A novel c.563 T>G, p.L189R lamin A/C mutation in identical twins with dilated cardiomyopathy
Euijae Lee, Kyung-Taek Park, Jinwoo Kang, Hyunkyung Park, Jin Joo Park, Il-Young Oh, Yeonyee E. Yoon
Korean J Intern Med. 2017;32(1):178-181. Published online March 8, 2016
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Letter to the editor
Recurrent pyogenic liver abscess as a presenting manifestation of colorectal cancer
Hee Yeon Kim, Chang Wook Kim, Dong Ryul Kim, Young Wook Cho, Jae-Young Cho, Woo Jung Kim, Hyung Gyu Choi
Korean J Intern Med. 2017;32(1):174-177. Published online February 3, 2016
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Rheumatology / Original Article
Autonomic dysfunction in primary Sjogren’s syndrome: a prospective cohort analysis of 154 Korean patients
Jung Hee Koh, Seung-Ki Kwok, Jennifer Lee, Sung-Hwan Park
Korean J Intern Med. 2017;32(1):165-173. Published online March 25, 2016
Background/Aims: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren’s syndrome (pSS) and its associations with the clinical features of pSS. Methods: We analyzed 154 participants from the Korean Initiative of primary Sjogren’s Syndrome (KISS) as a pros..
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Allergy / Original Article
Relationship between serum IgA level and allergy/asthma
Woo-Jin Kim, Inseon S. Choi, Chang Seong Kim, Jeong-Hyeon Lee, Hyeon-Wook Kang
Korean J Intern Med. 2017;32(1):137-145. Published online September 2, 2016
Background/Aims: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR). Methods: The clinical records of 1,136 adul..
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Hemato-oncology / Original Article
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Letter to the editor
Hepatocellular carcinoma hidden by multiple infarcted regenerative nodules
Jin Ah Kim, Hye Sung Ahn, Haneul Park, Yoo Rim Seo, Ju Hyun Seo, Chang Wook Kim, Hee Yeon Kim
Korean J Intern Med. 2016;31(6):1178-1180. Published online February 18, 2016
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