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Nephrology / Review
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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Pulmonology / Review
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Rheumatology / Original Article
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Korean J Intern Med. 2020;35(1):231-239. Published online January 28, 2019
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
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Hemato-oncology / Original Article
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance
Hee Kyung Kim, Wonseok Kang, Dong Hyun Sinn, Joon Hyeok Lee, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2020;35(1):194-204. Published online April 4, 2019
Background/Aims: Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL).
Methods: A cross-sectional study analyzed FL patients who were ..
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Nephrology / Original Article
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Pulmonology / Original Article
Analysis of high predicted pulmonary function: possibility of overestimation in small elderly examinees
Youjin Chang, Ho Cheol Kim, Kyung-Wook Jo, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Sei Won Lee
Korean J Intern Med. 2020;35(1):142-149. Published online October 17, 2019
Background/Aims: Few studies have attempted to interpret unusually high predicted pulmonary function test results. This study aimed to investigate the demographic features of patients with an unusually high predicted pulmonary function.
Methods: The demographic data of subjects who underwent pulmon..
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Cardiology / Original Article
A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF)
Hyeongsoo Kim, Young Soo Lee, Tae-Hoon Kim, Myung-Jin Cha, Jung Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Jae-Sun Uhm, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Changsoo Kim, Jun Kim, Boyoung Joung
Korean J Intern Med. 2020;35(1):99-108. Published online April 25, 2019
Background/Aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin K antagonists (VKAs) is a limitation. Although non-VKA OACs (NOACs) are m..
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Gastroenterology / Original Article
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Gastroenterology / Original Article
Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study
Won-Jong Yang, Eunhee Park, Yu-Sun Min, Jae-Won Huh, Ae Ryoung Kim, Hyun-Min Oh, Tae-Woo Nam, Tae-Du Jung
Korean J Intern Med. 2020;35(1):79-87. Published online January 2, 2020
Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs).
Methods: This study was a retrospective review of med..
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Review
Recent insights regarding the molecular basis of myeloproliferative neoplasms
Mi-Ae Jang, Chul Won Choi
Korean J Intern Med. 2020;35(1):1-11. Published online November 29, 2019
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the..
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Rheumatology / Original Article
Standardized, musculoskeletal ultrasonographic reference values for healthy Korean adults
Hyun-Sook Kim, Hae-Rim Kim, Bo Young Kim, Yun Sung Kim, Young Ok Jung, Sung Jae Choi, Hyun-Ok Kim, Jiwon Hwang, Sunggun Lee, Hyoun-Ah Kim, So Young Bang, Ji-Young Chai, Sung-Hoon Park, Chong-Hyeon Yoon
Korean J Intern Med. 2019;34(6):1372-1380. Published online May 4, 2018
Background/Aims: To define standard reference values for musculoskeletal ultrasonography (MSUS) in Korea.
Methods: A total of 251 healthy adults were recruited for this study. Ultrasonography was performed by experienced rheumatologists who had undergone four appropriate training programs in Korea..
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Hemato-oncology / Original Article
The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis
Hyera Kim, Kang Kook Lee, Mi Hwa Heo, Jin Young Kim
Korean J Intern Med. 2019;34(6):1324-1332. Published online October 26, 2018
Background/Aims: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of canc..
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Hemato-oncology / Original Article
Poor prognostic factors in human papillomavirus-positive head and neck cancer: who might not be candidates for de-escalation treatment?
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Korean J Intern Med. 2019;34(6):1313-1323. Published online November 16, 2018
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some pati..
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Pulmonology / Original Article
Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment
Renad Mammadov, Bahadir Suleyman, Selcuk Akturan, Ferda Keskin Cimen, Nezahat Kurt, Zeynep Suleyman, İsmail Malkoc
Korean J Intern Med. 2019;34(6):1279-1286. Published online September 10, 2019
Background/Aims: This study aimed to investigate the effect of lutein on methotrexate (MTX)-induced pulmonary toxicity in rats biochemically and histopathologically.
Methods: The rats in the MTX + lutein (MTXL, n = 6) group were given 1 mg/kg of lutein orally. A 0.9% NaCl solution was administered ..
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Gastroenterology / Original Article
Liver volume index predicts the risk of esophageal variceal hemorrhage in cirrhotic patients on propranolol prophylaxis
Beom Hee Kim, Jung Wha Chung, Chung Seop Lee, Eun Sun Jang, Sook-Hyang Jeong, Nayoung Kim, Jin-Wook Kim
Korean J Intern Med. 2019;34(6):1233-1243. Published online February 18, 2019
Background/Aims: Non-selective β-blockers (NSBBs) are used for primary prevention of esophageal variceal hemorrhage (VH) in patients with portal hypertension, but a significant number of patients develop VH while on NSBB therapy. In this study, we sought to determine whether liver volume can predi..
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Gastroenterology / Original Article
Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Korean J Intern Med. 2019;34(6):1223-1232. Published online October 26, 2018
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods: This study analyzed 175 conse..
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Gastroenterology / Original Article
Quality of information on the Internet for Korean patients with inflammatory bowel disease
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Korean J Intern Med. 2019;34(6):1215-1222. Published online October 1, 2018
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the..
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Review
Rheumatic complications in cancer patients treated with immune checkpoint inhibitors
Kyung-Ann Lee, Hae-Rim Kim, So Young Yoon
Korean J Intern Med. 2019;34(6):1197-1209. Published online April 25, 2019
Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-..
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Review
Achalasia: treatment, current status and future advances
Lee L. Swanström
Korean J Intern Med. 2019;34(6):1173-1180. Published online March 15, 2019
Achalasia was first described in the 17th century and its treatment continues to be challenging. Palliative treatment involves disruption of the lower esophageal sphincter, which can be accomplished mechanically (balloon dilation or surgical myotomy) or chemically (Botox). True surgical treatment or..
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Rheumatology / Original Article
Treatment patterns of knee osteoarthritis patients in Korea
Ha-Rim Park, Soo-Kyung Cho, Seul Gi Im, Sun-Young Jung, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung
Korean J Intern Med. 2019;34(5):1145-1153. Published online March 21, 2018
Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea.
Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in com..
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