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Nephrology / Original Article
Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy
Jae Ryung Shin, Seung Min Kim, Jung Sun Yoo, Ji Yoon Park, Seul Ki Kim, Joo Hee Cho, Kyung Hwan Jeong, Tae Won Lee, Chun Gyoo Ihm
Korean J Intern Med. 2014;29(3):334-340. Published online April 29, 2014
Background/Aims: β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a bio..
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Pulmonology / Review
Modifiers of TGF-b1 effector function as novel therapeutic targets of pulmonary fibrosis
Chang-Min Lee, Jin Wook Park, Won-Kyung Cho, Yang Zhou, Boram Han, Pyoung Oh Yoon, Jeiwook Chae, Jack A Elias, Chun Geun Lee
Korean J Intern Med. 2014;29(3):281-290. Published online April 29, 2014
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-b1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs including skin, liver, kidney, and lung. Thus, TGF-b1 and its signaling pathways have been at..
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Case Report
Isolated dilatation of the inferior vena cava
Jae-Joon Kim, Kyoung-Im Cho, Ji-Hoon Kang, Ja-Jun Goo, Kyoung-Nyoun Kim, Ja-Young Lee, Seong-Man Kim
Korean J Intern Med. 2014;29(2):241-245. Published online February 27, 2014
The diameter and collapsibility of the inferior vena cava (IVC) should be interpreted in consideration with other clinical and echocardiographic parameters before drawing definitive diagnostic conclusions. We report a case of a 46-year-old female with isolated IVC dilation and diminished inspiratory..
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Cardiology / Original Article
Effect of renin-angiotensin-system blockers on contrast-medium-induced acute kidney injury after coronary angiography
Ja-Jun Goo, Jae-Joon Kim, Ji-Hoon Kang, Kyoung-Nyoun Kim, Ki-Sup Byun, Mi-kyung Kim, Tae-Ik Kim
Korean J Intern Med. 2014;29(2):203-209. Published online February 27, 2014
Background/Aims: With the increasing incidence of cardiovascular disease, angiocardiography using contrast-enhancing media has become an essential diagnostic and therapeutic tool, despite the risk of contrast-medium-induced acute kidney injury (CIAKI). CIAKI may be exacerbated by renin-angiotensin-s..
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Nephrology / Original Article
Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
Ji-Hye Lee, Mee-Hye Oh, Jae-Seok Park, Gyoung-Jae Na, Hye-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2014;29(2):176-182. Published online February 27, 2014
Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).
Methods: Renal biopsy specimens from 52 IgA G..
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Letter to the editor
Eosinophilic organ infiltration without
eosinophilia or direct parasite infection
Il Young Jang, Young-Joo Yang, Hyung Jin Cho, Yunsik Choi, Eun-Hye Shin, Dong-Uk Kang, Tae-Bum Kim
Korean J Intern Med. 2014;29(1):126-129. Published online January 2, 2014
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Case Report
Spontaneous coronary artery dissection by
intravascular ultrasound in a patient with
myocardial infarction
Ji Hun Jang, Dae Hyeok Kim, Dong Hyuk Yang, Seong Il Woo, Jun Kwan, Keum Soo Park, Sung-Hee Shin
Korean J Intern Med. 2014;29(1):106-110. Published online January 2, 2014
Spontaneous coronary artery dissection is a rare cause of acute coronary syndrome
and sudden cardiac death. The incidence, causes, pathogenesis, and treatment
have not been defined clearly, but spontaneous coronary artery dissection
should be considered in young patients without major cardiovascu..
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Allergy / Original Article
Clinical features and prognostic factors of Churg-Strauss syndrome
Mi-Yeong Kim, Kyoung-Hee Sohn, Woo-Jung Song, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang
Korean J Intern Med. 2014;29(1):85-95. Published online January 2, 2014
Background/Aims: Churg-Strauss syndrome (CSS) is a rare systemic necrotizing
small-vessel vasculitis, with accompanying bronchial asthma, eosinophilia, and
eosinophilic infiltration of various tissues. The purposes of our study were to
characterize the clinical features of CSS and to identify fac..
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Cardiology / Original Article
Long-term outcomes of intravascular
ultrasound-guided implantation of bare metal
stents versus drug-eluting stents in primary
percutaneous coronary intervention
Yun-Kyeong Cho, Seung-Ho Hur, Nam-Hee Park, Sang-Woong Choi, Ji-Hyun Sohn, Hyun-Ok Cho, Hyoung-Seob Park, Hyuck-Jun Yoon, Hyungseop Kim, Chang-Wook Nam, Yoon-Nyun Kim, Kwon-Bae Kim
Korean J Intern Med. 2014;29(1):66-75. Published online January 2, 2014
Background/Aims: While drug-eluting stents (DESs) have shown favorable outcomes
in ST‑segment elevation myocardial infarction (STEMI) compared to bare
metal stents (BMSs), there are concerns about the risk of stent thrombosis (ST)
with DESs. Because intravascular ultrasound (IVUS) guidance may ..
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Gastroenterology / Original Article
Is propofol safe when administered to cirrhotic patients during sedative endoscopy?
Sang Jun Suh, Hyung Joon Yim, Eileen L. Yoon, Beom Jae Lee, Jong Jin Hyun, Sung Woo Jung, Ja Seol Koo, Ji Hoon Kim, Kyung Jin Kim, Rok Son Choung, Yeon Seok Seo, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun, Sang Woo Lee, Jai Hyun Choi, Ho Sang Ryu
Korean J Intern Med. 2014;29(1):57-65. Published online January 2, 2014
Background/Aims: In patients with liver cirrhosis, drugs acting on the central
nervous system can lead to hepatic encephalopathy and the effects may be prolonged.
Recently, misuse of propofol has been reported and the associated risk of
death have become an issue. Propofol is commonly used during..
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Acute respiratory failure caused by phenytoin overdose
Chang Kyung Kang, Min-Kyung Kim, Min Jae Kim, Kang Il Jun, Ki Woong Kim, Seong-Ho Park, Kyoung-Ho Song
Korean J Intern Med. 2013;28(6):736-738. Published online October 29, 2013
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Letter to the editor
Acute regional myocarditis with normal ventricular wall motion diagnosed by two-dimensional speckle tracking imaging
Sang Jin Ha, Jong Shin Woo, Se Hwan Kwon, Chi Hyuk Oh, Kwon Sam Kim, Jong-Hoa Bae, Woo-Shik Kim
Korean J Intern Med. 2013;28(6):732-735. Published online October 29, 2013
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Case Report
A case of Tsutsugamushi disease presenting with nephrotic syndrome
Ju Hyun Lee, Mi Jung Lee, Dong Ho Shin, Shin-Wook Kang, Kyu Hun Choi, Tae-Hyun Yoo
Korean J Intern Med. 2013;28(6):728-731. Published online October 29, 2013
Nephrotic syndrome associated with Tsutsugamushi disease has not been previously reported. We are describing a case of Tsutsugamuchi disease presenting with nephrotic syndrome. A 72-year-old woman presented with fever and generalized edema. Laboratory studies revealed a leukocytosis, hypoalbumine..
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Allergy / Original Article
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
Min-Hye Kim, Sae-Hoon Kim, Yook-Keun Kim, Soo-Jong Hong, Kyung-Up Min, Sang-Heon Cho, Heung-Woo Park
Korean J Intern Med. 2013;28(6):708-714. Published online October 29, 2013
Background/AimsRecent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and ..
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Infectious diseases
Predictors and clinical outcomes of persistent methicillin-resistant Staphylococcus aureus bacteremia: a prospective observational study
Hea Sung Ok, Hyoun Soo Lee, Man Je Park, Ki Hoon Kim, Byeong Ki Kim, Yu Mi Wi, June Myung Kim
Korean J Intern Med. 2013;28(6):678-686. Published online October 29, 2013
Background/AimsThe high mortality attributable to persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in spite of glycopeptide treatment has heightened the need for early detection and intervention with alternative agents. The purpose of t..
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Letter to the editor
Deep vein thrombosis associated with acute brucellosis: a case report and review of the literature
Makram Koubaa, Makram Frigui, Yousra Cherif, Moez Jallouli, Neila Kaddour, Mounir Ben Jemaa, Zouheir Bahloul
Korean J Intern Med. 2013;28(5):628-630. Published online August 14, 2013
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Case Report
A rare cause of dysphagia: compression of the esophagus by an anterior cervical osteophyte due to ankylosing spondylitis
İlknur Albayrak, Sinan Bağcacı, Ali Sallı, Sami Kucuksen, Hatice Uğurlu
Korean J Intern Med. 2013;28(5):614-618. Published online August 14, 2013
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatological disease affecting the axial skeleton with various extra-articular complications. Dysphagia due to a giant anterior osteophyte of the cervical spine in AS is extremely rare. We present a 48-year-old male with AS suffering from p..
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Case Report
Endoscopic ultrasound-guided fine needle aspiration of solid pseudopapillary tumors of the pancreas: a report of three cases
Hye Yon Park, Yoon Jung Lee, Jun Hee Lee, Min Ji Lee, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee
Korean J Intern Med. 2013;28(5):599-604. Published online August 14, 2013
The solid pseudopapillary tumor (SPT) of the pancreas is a rare but low-grade malignant tumor with a good prognosis after surgical excision. Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is a minimally invasive, safe and reliable way of diagnosing SPT by providing characteristic..
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Endocrinology-metabolism / Original Article
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
Heung Yong Jin, Youn Soo Cha, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(5):579-586. Published online August 14, 2013
Background/AimsVitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD).
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Nephrology / Original Article
Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes
Ja Min Byun, Cheol Hyun Lee, Sul Ra Lee, Ju Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
Korean J Intern Med. 2013;28(5):565-572. Published online August 14, 2013
Background/AimsIn several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk..
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