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Cardiology / Review
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Shir Lynn Lim, Carolyn Su Ping Lam
Korean J Intern Med. 2016;31(1):1-14. Published online December 28, 2015
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A no..
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Letter to the editor
Fabry disease previously diagnosed as Henoch-Schonlein purpura
Ji Hyeong Kim, Dong Hoon Han, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, So Young Jin
Korean J Intern Med. 2015;30(6):925-927. Published online October 30, 2015
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Infectious diseases / Original Article
Serum galactomannan levels in the diagnosis of invasive aspergillosis
Yildiz Okuturlar, Fahir Ozkalemkas, Beyza Ener, Sibel Ocak Serin, Esra Kazak, Tulay Ozcelik, Vildan Ozkocaman, Hasan Atilla Ozkan, Halis Akalin, Meral Gunaldi, Ridvan Ali
Korean J Intern Med. 2015;30(6):899-905. Published online October 30, 2015
Background/Aims: In this study, the sensitivity-specificity of galactomannan-enzyme immunoassay (GM-EIA) with a cut-off value of 0.5 for a single, two, or three consecutive positivity in the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients with hematological malignancy was inves..
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Hemato-oncology / Original Article
Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Hemato-oncology / Original Article
Analysis of factors affecting hemorrhagic diathesis and overall survival in patients with acute promyelocytic leukemia
Ho Jin Lee, Dong Hyun Kim, Seul Lee, Myeong Seok Koh, So Yeon Kim, Ji Hyun Lee, Suee Lee, Sung Yong Oh, Jin Yeong Han, Hyo-Jin Kim, Sung-Hyun Kim
Korean J Intern Med. 2015;30(6):884-890. Published online October 30, 2015
Background/Aims: This study investigated whether patients with acute promyelocytic leukemia (APL) truly fulfill the diagnostic criteria of overt disseminated intravascular coagulation (DIC), as proposed by the International Society on Thrombosis and Haemostasis (ISTH) and the Korean Society on Throm..
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Nephrology / Original Article
The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells
Samel Park, Il-woong Hwang, Jin-sheon Kim, Hyo-chul Kang, Su-Yeon Park, Hyo-wook Gil, Ho-yeon Song, Sae-yong Hong
Korean J Intern Med. 2015;30(6):873-883. Published online October 30, 2015
Background/Aims: Most pesticide formulations contain both chief and additive ingredients. But, the additives may not have been tested as thoroughly as the chief ingredients. The surfactant, nonyl phenoxypolyethoxylethanol (NP40), is an additive frequently present in pesticide formulations. We invest..
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Letter to the editor
Complete recovery of pyoderma gangrenosum after successful treatment of underlying hairy cell leukemia with cladribine
Anıl Tombak, Sinan Aygün, Ebru Serinsöz, Eyüp Naci Tiftik
Korean J Intern Med. 2015;30(5):739-741. Published online August 27, 2015
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Letter to the editor
Type 4 dual left anterior descending coronary artery
Chan Joon Kim, Hee Jeoung Yoon, Sung Ho Her, Jun Han Jeon, Seung Min Jung, Eun Hee Jang, Seung Won Jin
Korean J Intern Med. 2015;30(5):727-729. Published online August 27, 2015
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Infectious diseases / Original Article
The CD4 slope can be a predictor of immunologic recovery in advanced HIV patients: a case-control study
Kye-Hyung Kim, Jongyoun Yi, Sun Hee Lee
Korean J Intern Med. 2015;30(5):705-713. Published online August 27, 2015
Background/Aims: Advanced human immunodeficiency virus (HIV) infection, despite sustained viral suppression by highly active antiretroviral therapy (HAART), is a risk factor for poor immunologic recovery. However, some patients with advanced infection do show immunologic recovery. In this study, pre..
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Hemato-oncology / Original Article
The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea
Cheolsu Kim, Ho Sup Lee, Chang-Ki Min, Je Jung Lee, Kihyun Kim, Dok Hyun Yoon, Hyeon Seok Eom, Hyewon Lee, Won Sik Lee, Ho-Jin Shin, Ji Hyun Lee, Yong Park, Jae-Cheol Jo, Young Rok Do, Yeung-Chul Mun
Korean J Intern Med. 2015;30(5):675-683. Published online August 27, 2015
Background/Aims: The purpose of this study was to determine the correlations between inflammatory factors—including absolute lymphocyte count, lactate dehydrogenase, β2-microglobulin, albumin, C-reactive protein, and ferritin—and the prognosis for survival in patients with multiple myeloma (MM) ..
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Gastroenterology / Original Article
Can proton pump inhibitors reduce rebleeding following Histoacryl sclerotherapy for gastric variceal hemorrhage?
Ka Rham Kim, Chung Hwan Jun, Kyu Man Cho, Jin Woo Wi, Seon Young Park, Sung Bum Cho, Wan Sik Lee, Chang Hwan Park, Young Eun Joo, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
Korean J Intern Med. 2015;30(5):593-601. Published online August 27, 2015
Background/Aims: To evaluate the efficacy of proton pump inhibitors (PPIs) in reducing rebleeding and bleeding-related death rates after endoscopic gastric variceal obliteration (GVO) using N-butyl-2-cyanoacrylate (NBC).
Methods: This study enrolled 341 patients who were consecutively diagnosed wi..
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Rheumatology / Original Article
Allopurinol hypersensitivity syndrome in patients with hematological malignancies: characteristics and clinical outcomes
Hong Ki Min, Boin Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Young Min Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(4):521-530. Published online June 29, 2015
Background/Aims: Allopurinol is a urate-lowering agent that is commonly used to prevent chemotherapy-related hyperuricemia. Allopurinol hypersensitivity syndrome (AHS) is a disorder involving multiple organs, which may be accompanied by cutaneous adverse reactions. We identified the characteristics ..
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Pulmonology / Review
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Infectious diseases / Original Article
A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis
U-Im Chang, Hyung Wook Kim, Yong-sun Noh, Seong-Heon Wie
Korean J Intern Med. 2015;30(3):372-383. Published online April 29, 2015
Background/Aims: Acute pyelonephritis (APN) is the most common cause of community-onset bacteremia in hospitalized elderly patients. The objectives of this study were to investigate the differences in the clinical and microbiological data of hospitalized elderly and non-elderly women with community-..
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Nephrology / Original Article
High serum and urine neutrophil gelatinase-associated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy
Harin Rhee, Nari Shin, Min Ji Shin, Byung Yun Yang, Il Young Kim, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Eun Young Seong
Korean J Intern Med. 2015;30(3):354-361. Published online April 29, 2015
Background/Aims: Tubulointerstitial injury plays an important role in the progression of immunoglobulin A nephropathy (IgAN), and neutrophil gelatinase-associated lipocalin (NGAL) is among the most sensitive tubular biomarkers. We investigated whether serum or urine NGAL predicts prognosis in patien..
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Nephrology / Original Article
Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Ga-Young Park, Chung-Hoon Yu, Jun-Seop Kim, Yun-Jeong Kang, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2015;30(3):345-353. Published online April 29, 2015
Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).
Methods: In total, 91 patients with biopsy-proven IgAN ..
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Endocrinology-metabolism / Original Article
Reference interval for thyrotropin in a ultrasonography screened Korean population
Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-Don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2015;30(3):335-344. Published online April 29, 2015
Background/Aims: The diagnostic accuracy of thyroid dysfunctions is primarily affected by the validity of the reference interval for serum thyroid-stimulating hormone (TSH). Thus, the present study aimed to establish a reference interval for TSH using a normal Korean population.
Methods: This study..
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Gastroenterology / Original Article
Use of 18F-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
Min Jin Kim, Young Seok Kim, Youn Hee Cho, Hee Yoon Jang, Jeong-Yeop Song, Sae Hwan Lee, Soung Won Jeong, Sang Gyune Kim, Jae Young Jang, Hong Su Kim, Boo Sung Kim, Won Hyung Lee, Jung Mi Park, Jae Myung Lee, Min Hee Lee, Deuk Lin Choi
Korean J Intern Med. 2015;30(3):308-315. Published online April 29, 2015
Background/Aims: 18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and sur..
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Microbiology / Review
Clinical implications of copy number variations in autoimmune disorders
Seon-Hee Yim, Seung-Hyun Jung, Boram Chung, Yeun-Jun Chung
Korean J Intern Med. 2015;30(3):294-304. Published online April 29, 2015
Human genetic variation is represented by the genetic differences both within and among populations, and most genetic variants do not cause overt diseases but contribute to disease susceptibility and influence drug response. During the last century, various genetic variants, such as copy number var..
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Gastroenterology / Review
Recent trends in diagnostic techniques for inflammatory bowel disease
Makoto Naganuma, Naoki Hosoe, Takanori Kanai, Haruhiko Ogata
Korean J Intern Med. 2015;30(3):271-278. Published online April 29, 2015
Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, ..
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