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Allergy / Original Article
Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
Jun-Ho Myung, Hyun-Jeong Seo, Soo-Jeong Park, Bo-Young Kim, Il-Sang Shin, Jun-Hak Jang, Yun-Kyung Kim, An-Soo Jang
Korean J Intern Med. 2015;30(2):226-231. Published online February 27, 2015
Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness.
Methods: We co..
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Gastroenterology / Original Article
Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
Hyo Jin Kim, Ju-Yeon Cho, Yu Jin Kim, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2015;30(1):32-41. Published online December 30, 2014
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the efficacy ..
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Endocrinology-metabolism / Review
Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
Jae-Seung Yun, Seung-Hyun Ko
Korean J Intern Med. 2015;30(1):6-16. Published online December 30, 2014
Hypoglycemia is a major barrier to achieving the glycemic goal in patients with type 2 diabetes. In particular, severe hypoglycemia, which is defined as an event that requires the assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions, is a seri..
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Letter to the editor
Persistent suboptimal molecular response in a patient with chronic myelogenous leukemia and Klinefelter syndrome
Rajshekhar Chakraborty, Shiva Kumar Reddy Mukkamalla, Kranthi Singam, Natalia Calderon
Korean J Intern Med. 2014;29(6):827-829. Published online October 31, 2014
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Letter to the editor
Funtional significance of the intermediate lesion in a single coronary artery assessed by fractional flow reserve
Sang Jin Ha, Se Hwan Kwon, Soo-Joong Kim
Korean J Intern Med. 2014;29(6):822-824. Published online October 31, 2014
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Infectious diseases / Original Article
Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis
Ki-Ho Park, Mi Suk Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Joong Koo Kang, Sang-Ahm Lee, Sung-Han Kim
Korean J Intern Med. 2014;29(6):793-799. Published online October 31, 2014
Background/Aims: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal f luid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM) over the course of anti-TB therapy.
Methods: Adult pati..
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Hemato-oncology / Review
Recent advances in treatment of aplastic anemia
Seung Hwan Shin, Sung Eun Lee, Jong Wook Lee
Korean J Intern Med. 2014;29(6):713-726. Published online October 31, 2014
Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT) is a preferred first-line treatment option for younger patients with severe or very severe AA,..
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Cardiology / Review
The scientific achievements of the decades in Korean Acute Myocardial Infarction Registry
Hyun Kuk Kim, Myung Ho Jeong, Seung Hun Lee, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Chong Jin Kim, Myeong Chan Cho, Young Jo Kim
Korean J Intern Med. 2014;29(6):703-712. Published online October 31, 2014
The Korea Acute Myocardial Infarction Registry (KAMIR) was the first nationwide registry data collection designed to track outcomes of patients with acute myocardial infarction (AMI). These studies ref lect the current therapeutic approaches and management for AMI in Korea. The results of KAMIR coul..
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Pulmonology / Original Article
Factors predictive of the failure of medical treatment in patients with pleural infection
Sung-Kyoung Kim, Chul Ung Kang, So Hyang Song, Deog Gon Cho, Kyu Do Cho, Chi Hong Kim
Korean J Intern Med. 2014;29(5):603-612. Published online August 28, 2014
Background/Aims: The clinical outcomes of some patients with pleural infection may be favorable with medical treatment alone, but in others, the disease progresses and requires additional surgical treatment. However, little is known about the factors affecting this difference. The aim of this study ..
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Cardiology / Original Article
Long-term outcomes of simple crossover stenting from the left main to the left anterior descending coronary artery
Ho-Myung Lee, Chang-Wook Nam, Yun-Kyeong Cho, Hyuck-Jun Yoon, Hyoung-Seob Park, Hyungseop Kim, In-Sung Chung, Yun-Seok Heo, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim
Korean J Intern Med. 2014;29(5):597-602. Published online August 28, 2014
Background/Aims: Although complex bifurcation stenting in patients with nonleft main (LM) bifurcation lesions has not yielded better clinical outcomes than simpler procedures, the utility of complex bifurcation stenting to treat LM bifurcation lesions has not yet been adequately explored.
Methods: ..
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Gastroenterology / Original Article
A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
Su Jong Yu, Jae-Kyung Won, Han Suk Ryu, Won-Mook Choi, Hyeki Cho, Eun-Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Kyung-Suk Suh, Ja-June Jang, Chung Yong Kim, Hyo-Suk Lee, Jung-Hwan Yoon, Kwang-Hyun Cho
Korean J Intern Med. 2014;29(5):580-587. Published online August 28, 2014
Background/Aims: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has..
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Gastroenterology / Review
Crohn’s disease in Korea: past, present, and future
Kang-Moon Lee, Ji Min Lee
Korean J Intern Med. 2014;29(5):558-570. Published online August 28, 2014
The epidemiology, genetics, and clinical manifestations of Crohn’s disease (CD) vary considerably among geographic areas and ethnic groups. Thus, identifying the characteristics of Korean CD is important for establishing management strategies appropriate for Korean patients. Since the mid-2000s, m..
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Gastroenterology / Original Article
Clinical outcomes of gastric variceal obliteration using N-butyl-2-cyanoacrylate in patients with acute gastric variceal hemorrhage
Chung Hwan Jun, Ka Rham Kim, Jae Hyun Yoon, Han Ra Koh, Won Suk Choi, Kyu Man Cho, Sung Uk Lim, Chang Hwan Park, Young Eun Joo, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
Korean J Intern Med. 2014;29(4):437-444. Published online June 27, 2014
Background/Aims: To evaluate the long-term efficacy and safety of endoscopic injection of N-butyl-2-cyanoacrylate (NBC; Histoacryl) for treatment of bleeding gastric varices.
Methods: We retrospectively analyzed the records of 455 patients with gastric variceal hemorrhage (GVH) who were consecutiv..
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Letter to the editor
A case of Wegener’s granulomatosis mimicking recurrent hemophagocytic lymphohistiocytosis
Sung Min Jung, Yun Hwa Jung, Hyun Jin Noh, In Sook Woo, Chi Wha Han
Korean J Intern Med. 2014;29(3):393-397. Published online April 29, 2014
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Rheumatology / Original Article
Clinical factors and treatment outcomes associated with failure in the detection of urate crystal in patients with acute gouty arthritis
Jun Won Park, Dong Jin Ko, Jong Jin Yoo, Sung Hae Chang, Hyon Joung Cho, Eun Ha Kang, Jin Kyun Park, Yeong Wook Song, Yun Jong Lee
Korean J Intern Med. 2014;29(3):361-369. Published online April 29, 2014
Background/Aims: To investigate the rate of detection of monosodium urate (MSU) crystals in the synovial fluid (SF) of patients with acute gouty arthritis and factors associated with false-negative results.
Methods: A total of 179 patients with acute gouty arthritis who had undergo..
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Hemato-oncology / Original Article
Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer’s ring: nationwide Korean study
Seong Jun Lee, Cheol Won Suh, Soon Il Lee, Won Seog Kim, Won Sik Lee, Hyo Jung Kim, Chul Won Choi, Jin Seok Kim, Jin Seok Kim, Ho-Jin Shin, Ho-Jin Shin, The Consortium for Improving Survival of Lymphoma , The Consortium for Improving Survival of Lymphoma
Korean J Intern Med. 2014;29(3):352-360. Published online April 29, 2014
Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer’s ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectiv..
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Nephrology / Original Article
Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy
Jae Ryung Shin, Seung Min Kim, Jung Sun Yoo, Ji Yoon Park, Seul Ki Kim, Joo Hee Cho, Kyung Hwan Jeong, Tae Won Lee, Chun Gyoo Ihm
Korean J Intern Med. 2014;29(3):334-340. Published online April 29, 2014
Background/Aims: β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a bio..
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Endocrinology-metabolism / Original Article
Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data
Won Gu Kim, Tae Yong Kim, Tae Hyuk Kim, Hye Won Jang, Young Suk Jo, Young Joo Park, Sun Wook Kim, Won Bae Kim, Minho Shong, Do Joon Park, Jae Hoon Chung, Young Kee Shong, Bo Youn Cho
Korean J Intern Med. 2014;29(3):325-333. Published online April 29, 2014
Background/Aims: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma (HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine- sufficient areas. In this study we evaluated the clinical behavior, prognostic factors and treatment outcomes of FTC and HCC in Korea.
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Case Report
Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma
Suh Yoon Yang, Bong Ki Cha, Gihyeon Kim, Hyun Woong Lee, Jae Gyu Kim, Sae Kyung Chang, Hyung Joon Kim
Korean J Intern Med. 2014;29(2):231-235. Published online February 27, 2014
Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian c..
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Nephrology / Original Article
Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
Ji-Hye Lee, Mee-Hye Oh, Jae-Seok Park, Gyoung-Jae Na, Hye-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2014;29(2):176-182. Published online February 27, 2014
Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).
Methods: Renal biopsy specimens from 52 IgA G..
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