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Review
Endoscopic Therapy in Chronic Pancreatitis
Damien Meng Yew Tan, Stuart Sherman
Korean J Intern Med. 2011;26(4):384-399. Published online November 28, 2011
Chronic pancreatitis (CP) is a debilitating disease that can result in chronic abdominal pain, malnutrition, and other related complications. The main aims of treatment are to control symptoms, prevent disease progression, and correct any complications. A multidisciplinary approach involving medi..
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Review
Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic
Jae Youn Cho
Korean J Intern Med. 2011;26(4):367-383. Published online November 28, 2011
Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in asthma, including transforming growth factor-β, interleukin (IL)-5, basic fib..
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Original Article
Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience
Dong-Yeop Shin, Inho Kim, Ki-Hwan Kim, Younak Choi, Seung Hoon Beom, Yaewon Yang, Yoojoo Lim, Eunyoung Lee, June Koo Lee, Ji Yeon Kim, Hyun Kyung Kim, Sung-Soo Yoon, Dong Soon Lee, Seonyang Park, Byoung-Kook Kim
Korean J Intern Med. 2011;26(3):328-339. Published online September 13, 2011
Background/AimsWe investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). MethodsWe reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of el..
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Image of interest
A Case of Coarctation of the Aorta Diagnosed by Tardus-Parvus Renal Doppler Flow Patterns
Yun-Hwa Jung, Kwan-Wook Kim, Dae-Yoon Kim, Chul-Seung Lee
Korean J Intern Med. 2011;26(2):216-217. Published online June 1, 2011
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Case Report
False-Positive Hypermetabolic Lesions on Post-Treatment PET-CT after Influenza Vaccination
Jeong-Eun Kim, Eun Kyoung Kim, Dae Ho Lee, Sang-We Kim, Cheolwon Suh, Jung-Shin Lee
Korean J Intern Med. 2011;26(2):210-212. Published online June 1, 2011
We report a case of a 59-year-old man with testicular germ cell tumor who showed new hypermetabolic lesions at the left axillary lymph nodes on a post-treatment positron emission tomography-computed tomography (PET-CT) scan. The hypermetabolic lesions were found to be caused by an influenza vacci..
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Original Article
Role of IL-1α in Cisplatin-Induced Acute Renal Failure in Mice
Jay-Wook Lee, Woo-Jin Nam, Min-Jee Han, Jung-Ho Shin, Jin-Gun Kim, Su-Hyun Kim, Hye-Ryoun Kim, Dong-Jin Oh
Korean J Intern Med. 2011;26(2):187-194. Published online June 1, 2011
Background/AimsFor unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mic..
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Review
Klotho and the Aging Process
Makoto Kuro-o
Korean J Intern Med. 2011;26(2):113-122. Published online June 1, 2011
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the th..
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Case Report
Lymphocytic Interstitial Pneumonia in Primary Sjögren's Syndrome: A Case Report
Ji-Young Kim, Sung-Hoon Park, Seong-Kyu Kim, Dae-Sung Hyun, Yoon Seup Kum, Kyung-Jae Jung, Jung-Yoon Choe
Korean J Intern Med. 2011;26(1):108-111. Published online March 2, 2011
Sjögren's syndrome (SS) is an autoimmune disorder in which lymphocytes infiltrate the exocrine glands, resulting in the development of sicca symptoms. Lymphocytes may also invade various other organs and cause diverse symptoms. Interstitial pneumonia has been observed frequently in SS patients...
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Original Article
Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum β-Lactamase Production in Proteus mirabilis Bacteremia
Kyung Mok Sohn, Cheol-In Kang, Eun-Jeong Joo, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2011;26(1):89-93. Published online March 3, 2011
Background/AimsWe evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance. MethodsFrom October 2000 to July 2009, 37 patients with clinically signific..
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Review
Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
Masafumi Arima, Takeshi Fukuda
Korean J Intern Med. 2011;26(1):8-18. Published online March 2, 2011
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. R..
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Case Report
Postoperative High-Dose Intravenous Iron Sucrose with Low Dose Erythropoietin Therapy after Total Hip Replacement
Jiyeol Yoon, Sungmin Kim, Soo Chan Lee, Hongsub Lim
Korean J Intern Med. 2010;25(4):454-457. Published online November 27, 2010
Erythropoietin combined with parenteral iron sucrose therapy is an alternative to blood transfusion in anemic patients. It was shown to be effective in surgical patients in several previous studies when used in conjunction with other methods. However, there are no guidelines about safety limits i..
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Original Article
Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication
Joong-Rock Hong, Su-Jin Seok, Du-Shin Jeong, Sang-Gon Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2010;25(4):422-428. Published online November 27, 2010
Background/AimsMany patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical out..
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Original Article
Role of 68Ga-DOTATOC PET/CT in the Evaluation of Primary Pulmonary Carcinoids
Tarun Jindal, Arvind Kumar, Balasubramanian Venkitaraman, Roman Dutta, Rakesh Kumar
Korean J Intern Med. 2010;25(4):386-391. Published online November 27, 2010
Background/AimsAlthough carcinoid tumors usually have good prognosis, early and specific diagnosis is important. Computed tomography and magnetic resonance imaging do not provide findings that are specific for carcinoids, and somatostatin receptor scintigraphy suffers from low..
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Original Article
Usual Dose of Simvastatin Does Not Inhibit Plaque Progression and Lumen Loss at the Peri-Stent Reference Segments after Bare-Metal Stent Implantation: A Serial Intravascular Ultrasound Analysis
Young Joon Hong, Myung Ho Jeong, Yun Ha Choi, Eun Hye Ma, Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Youn, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2010;25(4):356-363. Published online November 27, 2010
Background/AimsThe aim of this study was to assess the effects of a usual dose of simvastatin (20 mg/day) on plaque regression and vascular remodeling at the peri-stent reference segments after bare-metal stent implantation. MethodsWe retrospect..
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Review
The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
Young Koog Cheon
Korean J Intern Med. 2010;25(4):345-352. Published online November 27, 2010
The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodyn..
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Original Article
Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
Hae-Rim Kim, Mi-Kyung Park, Mi-La Cho, Kyoung-Woon Kim, Hye-Joa Oh, Jin-Sil Park, Yang-Mi Heo, Sang-Heon Lee, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(3):317-326. Published online August 31, 2010
Background/AimsThis study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. MethodsHuman RA synovial fibr..
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Original Article
Modified Number of Extranodal Involved Sites as a Prognosticator in R-CHOP-Treated Patients with Disseminated Diffuse Large B-Cell Lymphoma
Changhoon Yoo, Shin Kim, Byeong Seok Sohn, Jeong-Eun Kim, Dok Hyun Yoon, Jooryung Huh, Dae Ho Lee, Sang-We Kim, Jung-Shin Lee, Cheolwon Suh
Korean J Intern Med. 2010;25(3):301-308. Published online August 31, 2010
Background/AimsRituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP) has improved survival in patients with diffuse large B-cell lymphoma (DLBCL) and weakened the prognostic power of the international prognostic index (IPI). We evaluat..
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Review
Non-gastric Marginal Zone B-cell Lymphoma in Korea: Clinical Features, Treatment, and Prognostic Factors
Sung Yong Oh, Cheolwon Suh
Korean J Intern Med. 2010;25(3):227-236. Published online August 31, 2010
Marginal zone B-cell lymphoma (MZL) is the second most common subtype of non-Hodgkin's lymphoma in Korea (17.3%). Mucosa-associated lymphoid tissue (MALT) can develop in almost any organ as a result of exposure to a persistent stimulus, such as chronic infection or certain autoimmune processes. U..
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Original Article
Variable Association between Components of the Metabolic Syndrome and Electrocardiographic Abnormalities in Korean Adults
Hong-Kyu Kim, Chul-Hee Kim, Kwan-Ho Ko, Seong-Wook Park, Joong-Yeol Park, Ki-Up Lee
Korean J Intern Med. 2010;25(2):174-180. Published online June 1, 2010
Background/AimsResting electrocardiogram (ECG) abnormalities have been strongly associated with cardiovascular disease mortality. Little is known, however, about the association between individual components of metabolic syndrome and ECG abnormalities, especially in Asian popu..
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Original Article
Severe Pulmonary Adverse Effects in Lymphoma Patients Treated with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) Regimen Plus Rituximab
Kyu-Hyoung Lim, Ho-Il Yoon, Young Ae Kang, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jae Ho Lee, Choon-Taek Lee, Jong Seok Lee
Korean J Intern Med. 2010;25(1):86-92. Published online February 26, 2010
Background/AimsThe aim of our study was to determine the incidence and clinical features of severe pulmonary complications in patients receiving cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab plus CHOP (R-CHOP) as the initial treatment for lymph..
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