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Nephrology / Original Article
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
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Pulmonology / Original Article
Qualitative and quantitative results of interferon-γ release assays for monitoring the response to anti-tuberculosis treatment
I-Nae Park, Tae Sun Shim
Korean J Intern Med. 2017;32(2):302-308. Published online December 13, 2016
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB.
Methods: From a retrospective review, we..
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Cardiology / Original Article
Features of electrocardiogram in patients with stenosis of the proximal right coronary artery
Moo Seong Koh, Jae Hoon Lee, Jin Woo Jeong, Jun Young Chung
Korean J Intern Med. 2017;32(2):277-285. Published online February 14, 2017
Background/Aims: Prediction of lesions of the proximal right coronary artery (pRCA) through electrocardiogram (ECG) is very important because pRCA occlusion has many complications and a high mortality rate, which has frequently been related with right ventricular infarction. The purpose of this stud..
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Gastroenterology / Original Article
Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
Su Jong Yu, Jung-Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-Ju Yoo, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Korean J Intern Med. 2017;32(2):261-268. Published online April 5, 2016
Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood m..
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Gastroenterology / Review
Reversal of liver cirrhosis: current evidence and expectations
Young Kul Jung, Hyung Joon Yim
Korean J Intern Med. 2017;32(2):213-228. Published online February 8, 2017
In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown regression of fibrosis and reversal of cirrhosis on repeated biopsy samples. As v..
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Rheumatology / Original Article
Autonomic dysfunction in primary Sjogren’s syndrome: a prospective cohort analysis of 154 Korean patients
Jung Hee Koh, Seung-Ki Kwok, Jennifer Lee, Sung-Hwan Park
Korean J Intern Med. 2017;32(1):165-173. Published online March 25, 2016
Background/Aims: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren’s syndrome (pSS) and its associations with the clinical features of pSS. Methods: We analyzed 154 participants from the Korean Initiative of primary Sjogren’s Syndrome (KISS) as a pros..
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Hemato-oncology / Original Article
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Gastroenterology / Original Article
Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
Ji Yeon Kim, Dong Il Park, Dong Soo Han, Kyu-Chan Huh, Chang Kyun Lee, Jeong Eun Shin, Jae Hak Kim, You Sun Kim, Yunho Jung, Sung-Ae Jung, Hyun Joo Song, Hyun Joo Jang, Young-Ho Kim, Sung No Hong
Korean J Intern Med. 2017;32(1):69-78. Published online June 25, 2016
Background/Aims: The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea. Methods: A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The ba..
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Endocrinology-metabolism / Review
Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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Rheumatology / Review
CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells
Eun Ji Kim, Ki Ho Kang, Ji Hyeon Ju
Korean J Intern Med. 2017;32(1):42-61. Published online January 1, 2017
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly clustered regularly interspaced short palindromic repeats (CRISPR)—will allow us to impro..
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Nephrology / Review
New therapeutic agents in diabetic nephropathy
Yaeni Kim, Cheol Whee Park
Korean J Intern Med. 2017;32(1):11-25. Published online January 1, 2017
Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and progression. Currently, there are few therapeutic drugs for DN, which mainly consist..
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Endocrinology-metabolism / Review
Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan
Korean J Intern Med. 2017;32(1):1-10. Published online January 1, 2017
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient complian..
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Letter to the editor
Pulmonary graft-versus-host disease after autologous hematopoietic stem cell transplantation
Sue In Choi, Eun Joo Lee, Dong Oh Kang, Sang Yeub Lee, Kwang Ho In, Han-Kyeom Kim, Sanghoon Park
Korean J Intern Med. 2016;31(6):1181-1183. Published online December 23, 2015
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Nephrology / Original Article
The impact of blood flow rate during hemodialysis on all-cause mortality
Kyung Yoon Chang, Su-Hyun Kim, Young Ok Kim, Dong Chan Jin, Ho Chul Song, Euy Jin Choi, Yong-Lim Kim, Yon-Su Kim, Shin-Wook Kang, Nam-Ho Kim, Chul Woo Yang, Yong Kyun Kim
Korean J Intern Med. 2016;31(6):1131-1139. Published online February 22, 2016
Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact o..
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Nephrology / Original Article
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Pulmonology / Original Article
Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012
Young Soo Kim, Hee Yeon Kim, Hyo-Suk Ahn, Tae Seo Sohn, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae, Kyungdo Han, Chang Dong Yeo
Korean J Intern Med. 2016;31(6):1101-1109. Published online March 21, 2016
Background/Aims: The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtrati..
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Cardiology / Original Article
Blood count parameters can predict the severity of coronary artery disease
Hilal Bektas Uysal, Bekir Dağlı, Cağdaş Akgüllü, Mücahit Avcil, Cemil Zencir, Mediha Ayhan, Hulki Meltem Sönmez
Korean J Intern Med. 2016;31(6):1093-1100. Published online April 7, 2016
Background/Aims: Because of the inflammatory nature of coronary artery disease (CAD), both platelets and white blood cells have been investigated for years. The aim of this study was to investigate the relationships between some prominently hematologic blood count parameters (mean platelet volume [M..
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Gastroenterology / Original Article
Diagnostic accuracy of 22/25-gauge core needle in endoscopic ultrasound-guided sampling: systematic review and meta-analysis
Hyoung-Chul Oh, Hyun Kang, Jae Young Lee, Geun Joo Choi, Jung Sik Choi
Korean J Intern Med. 2016;31(6):1073-1083. Published online September 2, 2016
Background/Aims: To compare the diagnostic accuracy of endoscopic ultrasound-guided core needle aspiration with that of standard fine-needle aspiration by systematic review and meta-analysis.
Methods: Studies using 22/25-gauge core needles, irrespective of comparison with standard fine needles, wer..
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Letter to the editor
Relapsing polychondritis presenting with inflammatory pseudotumor
Yeong Hee Eun, Hyeri Seok, In Seub Shin, Seung-Eun Lee, You-Bin Lee, Jaejoon Lee
Korean J Intern Med. 2016;31(5):1003-1005. Published online March 11, 2016
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Letter to the editor
A confusing case of multiple sclerosis and central nervous system graft versus host disease
Byung-Nam Yoon, Choong Kun Ha, Kwang-Woo Lee, Sung-Hye Park, Jung-Joon Sung
Korean J Intern Med. 2016;31(5):995-998. Published online February 3, 2016
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