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Original Article
Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma
Byoung Hoon Lee, Sang-Hoon Kim
Korean J Intern Med. 2007;22(4):244-248. Published online December 20, 2007
BackgroundAlthough benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous soluti..
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Original Article
Airways are More Reactive to Histamine than to Methacholine in Patients with Mild Airway Hyperresponsiveness, Regardless of Atopy
Inseon S. Choi, Seok Lee, Dae-Hyeon Kim, Se-Woong Chung, Yoon-Cheol Lee, Jae-Yeong Cho, Woo-Jin Lee
Korean J Intern Med. 2007;22(3):164-170. Published online September 30, 2007
BackgroundThe airway muscles from allergen-sensitized animals in vitro show a heightened response to histamine, but not to carbachol. This study investigated whether the airway responsiveness to histamine in vivo is comparable to that of metha..
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Original Article
Airway Hyperresponsiveness to Hypertonic Saline as a Predictive Index of Exercise-Induced Bronchoconstriction
Inseon S. Choi, Se-Woong Chung, Youngil I. Koh, Myoung-Ki Sim, Seo-Na Hong, Jang-Sik Moon
Korean J Intern Med. 2005;20(4):284-289. Published online December 31, 2005
BackgroundChanges in airway mucosal osmolarity are an underlying mechanism of bronchoconstrictive responses to exercise and hypertonic saline (HS). The purpose of this study was to examine whether an osmotic challenge test using HS can predict exercise-induced bronchospasm (EI..
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Original Article
Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma
Jung-Mi Oh, Seung-Hyun Kim, Chang-Hee Suh, Dong-Ho Nahm, Hae-Sim Park, Young-Mok Lee, June-Hyuk Lee, Choon-Sik Park, Hyung-Doo Shin
Korean J Intern Med. 2005;20(3):232-236. Published online September 30, 2005
BackgroundGlutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be asso..
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Original Article
Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
Yoon-Seok Chang, Yoon-Keun Kim, Joon-Woo Bahn, Sang-Heon Kim, Heung-Woo Park, Tae-Bum Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim
Korean J Intern Med. 2005;20(2):152-158. Published online June 30, 2005
BackgroundSeveral methods have been reported to induce asthmatic reactions in mice but few studies have compared their efficiency. We evaluated the efficiency of the protocols frequently used in the literature. MethodsBALB/c mice were sensitized..
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