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Review
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
Jae-Ho Yoon, Chul Won Choi, Jong-Ho Won
Korean J Intern Med. 2021;36(6):1261-1280. Published online September 24, 2021
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecif..
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Geriatrics / Original Article
Validity of the Clinical Frailty Scale in Korean older patients at a geriatric clinic
Hee-Won Jung, Il-Young Jang, Ji Yeon Back, Seunghyun Park, Chan MI Park, Seung Jun Han, Eunju Lee
Korean J Intern Med. 2021;36(5):1242-1250. Published online December 30, 2020
Background/Aims: We aimed to assess the validity of the Korean translated version of the Clinical Frailty Scale (CFS) in determining the frailty status in geriatric outpatients.
Methods: The records of 123 ambulatory outpatients who had undergone CFS and comprehensive geriatric assessments (CGAs) i..
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Review
Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
Korean J Intern Med. 2021;36(5):1049-1058. Published online September 1, 2021
The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-ce..
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Review
Strategies for successful implementation and permanent maintenance of a rapid response system
Myung Jin Song, Yeon Joo Lee
Korean J Intern Med. 2021;36(5):1031-1039. Published online August 18, 2021
Rapid response systems (RRSs) have been introduced to intervene with patients experiencing non-code medical emergencies and operate widely around the world. An RRS has four components: an afferent limb, an efferent limb, quality improvement, and administration. A proper triggering system, a hospital..
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Rheumatology / Original Article
Developing the Korean Educational Needs Assessment Tool (Korean ENAT) in rheumatoid arthritis: cross-cultural validation using Rasch analysis
Yoon-Kyoung Sung, Hyoungyoung Kim, Sung Joo Cha, Sae-Hyung Kim, Mwidimi Ndosi, Soo-Kyung Cho
Korean J Intern Med. 2021;36(4):1014-1022. Published online October 30, 2020
Background/Aims: This study was performed to undertake cross-cultural adaptation and validation of the Educational Needs Assessment Tool (ENAT) in rheumatoid arthritis (RA) for use in Korea.
Methods: The study involved two main phases: cross-cultural adaptation of the ENAT from English into Korean,..
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Cardiology / Original Article
Apparent treatment-resistant hypertension among ambulatory hypertensive patients: a cross-sectional study from 13 general hospitals
Sehun Kim, Jin Joo Park, Mi-Seung Shin, Choong Hwan Kwak, Bong-Ryeol Lee, Sung-Ji Park, Hae-Young Lee, Sang-Hyun Kim, Seok-Min Kang, Byung-Su Yoo, Joong-Wha Chung, Si Wan Choi, Sang-Ho Jo, Jinho Shin, Dong-Ju Choi
Korean J Intern Med. 2021;36(4):888-897. Published online June 7, 2021
Background/Aims: To examine the prevalence and clinical characteristics of apparent treatment-resistant hypertension among ambulatory hypertensive patients.
Methods: We enrolled adult ambulatory hypertensive patients at 13 well-qualified general hospitals in Korea from January to June 2012. Apparen..
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Gastroenterology / Original Article
Application of deep learning to predict advanced neoplasia using big clinical data in colorectal cancer screening of asymptomatic adults
Hyo-Joon Yang, Chang Woo Cho, Jongha Jang, Sang Soo Kim, Kwang-Sung Ahn, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2021;36(4):845-856. Published online October 23, 2020
Background/Aims: We aimed to develop a deep learning model for the prediction of the risk of advanced colorectal neoplasia (ACRN) in asymptomatic adults, based on which colorectal cancer screening could be customized.
Methods: We collected data on 26 clinical and laboratory parameters, including ag..
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Guideline
Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020
Hye-Kyung Jung, Seung Joo Kang, Yong Chan Lee, Hyo-Joon Yang, Seon-Young Park, Cheol Min Shin, Sung Eun Kim, Hyun Chul Lim, Jie-Hyun Kim, Su Youn Nam, Woon Geon Shin, Jae Myung Park, Il Ju Choi, Jae Gyu Kim, Miyoung Choi; Korean College of Helicobacter and Upper Gastrointesinal Research
Korean J Intern Med. 2021;36(4):807-838. Published online June 8, 2021
Helicobacter pylori infection is one of the most common infectious diseases worldwide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the H. pylori Clinical Practice Guidelines in 2013 in Korea, the eradicati..
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Nephrology / Original Article
Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2021;36(2):392-400. Published online July 7, 2020
Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT..
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Cardiology / Original Article
Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation
Dong-Hyuk Cho, Jong-Il Choi, Jimi Choi, Yun Gi Kim, Suk-Kyu Oh, Hyungdon Kook, Kwang No Lee, Jaemin Shim, Seong-Mi Park, Wan Joo Shim, Young-Hoon Kim
Korean J Intern Med. 2021;36(2):342-351. Published online February 27, 2020
Background/Aims: Vascular disease is an established risk factor for stroke in patients with atrial fibrillation (AF), which is included in CHA2DS2-VASc score. However, the role of carotid atherosclerosis remains to be determined.
Methods: Three hundred-ten patients with AF who..
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Cardiology / Original Article
Progression of ascending aortopathy may not occur after transcatheter aortic valve replacement in severe bicuspid aortic stenosis
Ji-Hyun Jung, Hyung-Kwan Kim, Jun-Bean Park, Seung-Pyo Lee, Bon-Kwon Koo, Yong-Jin Kim, Hyo-Soo Kim, Dae-Won Sohn
Korean J Intern Med. 2021;36(2):332-341. Published online August 14, 2019
Background/Aims: We evaluated changes in the ascending aorta dimension post-transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BiAV) and tricuspid aortic valve (TAV) patients.
Methods: Patients with severe aortic stenosis undergoing TAVR at Seoul National University Hospital we..
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Hemato-oncology / Original Article
Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study
Yunsuk Choi, Jung-Hee Lee, Chul Won Jung, Jae-Cheol Jo, Jin Seok Kim, Inho Kim, Silvia Park, June-won Cheong, Sang-Hyuk Park, Sung-Yong Kim, Hong-Ghi Lee
Korean J Intern Med. 2021;36(1):194-204. Published online April 14, 2020
Background/Aims: Compared with Western countries, chronic lymphocytic leukemia (CLL) rarely occurs in Asia and has different clinical characteristics. Thus, we aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic significance of Korean patients with CLL.
Methods: We re..
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Cardiology / Original Article
Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina
Sung Eun Kim, Sang-Ho Jo, Seung Hwan Han, Kwan Yong Lee, Sung Ho Her, Min-Ho Lee, Won-Woo Seo, Seong-Sik Cho, Sang Hong Baek
Korean J Intern Med. 2021;36(1):124-134. Published online February 24, 2020
Background/Aims: Calcium channel blockers (CCBs) are the most widely prescribed medication for patients with vasospastic angina (VA). However, few studies have compared the prognosis of VA patients who are prescribed different CCBs.
Methods: We enrolled 2,960 patients who received provocation test ..
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Review
The role of endoscopic therapy in the minimally invasive management of pancreatic necrosis
Jeffrey James Easler
Korean J Intern Med. 2021;36(1):32-44. Published online January 1, 2021
Pancreatic necrosis is among the most frequently encountered local complications of acute pancreatitis and associates with severe disease. Infected pancreatic necrosis further enhances the risk for morbidity and mortality. Pancreatic fluid collections that result from pancreatic necrosis evolve from..
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Review
Recommendations for the management of patients with systemic rheumatic diseases during the coronavirus disease pandemic
Mi Ryoung Seo, Ji-Won Kim, Eun-Jung Park, Seung Min Jung, Yoon-Kyoung Sung, Hyungjin Kim, Gunwoo Kim, Hyun-Sook Kim, Myeung-Su Lee, Jisoo Lee, Ji An Hur, Bum Sik Chin, Joong Sik Eom, Han Joo Baek; The Korean College of Rheumatology working group
Korean J Intern Med. 2020;35(6):1317-1332. Published online September 15, 2020
Patients with systemic rheumatic diseases (SRD) are vulnerable for coronavirus disease (COVID-19). The Korean College of Rheumatology recognized the urgent need to develop recommendations for rheumatologists and other physicians to manage patients with SRD during the COVID-19 pandemic. The working g..
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Geriatrics / Original Article
Sarcopenia is associated with severe erectile dysfunction in older adults: a population-based cohort study
Hyungchul Park, Il-Young Jang, Minkyu Han, Heayon Lee, Hee-Won Jung, Eunju Lee, Dae Hyun Kim
Korean J Intern Med. 2020;35(5):1245-1253. Published online April 21, 2020
Background/Aims: Sarcopenia and erectile dysfunction (ED) are associat ed with poor health and quality of life in older men. We investigate the association between sarcopenia and severe ED in community-dwelling older men.
Methods: We prospectively assessed sarcopenia and ED in 519, community-dwelli..
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Pulmonology / Original Article
Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study
Jaeyoung Cho, Chang-Hoon Lee, Deog Kyeom Kim, Hun-Gyu Hwang, Yu-Il Kim, Hye Sook Choi, Jeong-Woong Park, Kwang Ha Yoo, Ki-Suck Jung, Sang-Do Lee; the KOLD and KOCOSS Investigators
Korean J Intern Med. 2020;35(5):1154-1163. Published online February 27, 2020
Background/Aims: Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ..
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Hemato-oncology / Original Article
Is immunological recovery clinically relevant at 100 days after allogeneic transplantation?
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park
Korean J Intern Med. 2020;35(4):957-969. Published online April 21, 2020
Background/Aims: Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Methods: We assessed the clinical factors contributing to immune function reconstitution at 100 days post-allogeneic HSCT in 114 p..
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Hemato-oncology / Original Article
Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study
Yoon Ho Ko, Seung Joon Kim, Wan-Seop Kim, Chan Kwon Park, Cheol-Kyu Park, Yang-Gun Suh, Jung Seop Eom, Sukki Cho, Jae Young Hur, Sung Ho Hwang, Jun-Pyo Myong
Korean J Intern Med. 2020;35(3):692-702. Published online February 19, 2020
Background/Aims: We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females.
Methods: The study data were collected from a general health examination and questionnaire survey of eligible populations conducte..
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Nephrology / Review
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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