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Pulmonology / Original Article
Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion
Jaehee Lee, Deok Heon Lee, Ji Eun Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung-Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2024;39(2):318-326. Published online February 14, 2024
Background/Aims: Epidermal growth factor receptor (EGFR) mutation is important in determining the treatment strategy for advanced lung cancer patients with malignant pleural effusion (MPE). Contrary to serum carcinoembryonic antigen (S-CEA) levels, the associations between pleural fluid CEA (PF-CEA)..
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Pulmonology / Original Article
Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study
Eunki Chung, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Heejin Kim, Heesun Kim, Hongjo Choi, Young Ae Kang
Korean J Intern Med. 2024;39(2):306-317. Published online February 6, 2024
Background/Aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM.
Methods: This cohort study included patients w..
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Cardiology / Review
Nighttime administration of antihypertensive medication: a review of chronotherapy in hypertension
Hyun-Jin Kim, Sang-Ho Jo
Korean J Intern Med. 2024;39(2):205-214. Published online November 16, 2023
Hypertension remains a global health concern because of suboptimal blood pressure control despite advancements in antihypertensive treatments. Chronotherapy, defined as evening or bedtime administration of medication based on biological rhythms, is emerging as a potential strategy to improve blood p..
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Rheumatology / Original Article
Clinical characteristics and prognostic factors of non-tuberculous mycobacterial disease in patients with rheumatoid arthritis
Hyemin Kim, Soyoung Lee, Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2024;39(1):172-183. Published online November 30, 2023
Background/Aims: This study aimed to identify the clinical characteristics of patients with concurrent rheumatoid arthritis (RA) and suspected non-tuberculous mycobacterial (NTM) infections as well as determine their prognostic factors.
Methods: We retrospectively reviewed the medical records of 91..
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Endocrinology-metabolism / Original Article
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis
Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim
Korean J Intern Med. 2024;39(1):148-159. Published online December 22, 2023
Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications.
Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..
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Cardiology / Original Article
Sex differences in clinical characteristics and long-term outcome in patients with heart failure: data from the KorAHF registry
Hyue Mee Kim, Hack-Lyoung Kim, Myung-A Kim, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi; on the behalf of the KorAHF Investigators
Korean J Intern Med. 2024;39(1):95-109. Published online December 14, 2023
Background/Aims: Sex differences in the prognosis of heart failure (HF) have yielded inconsistent results, and data from Asian populations are even rare. This study aimed to investigate sex differences in clinical characteristics and long-term prognosis among Korean patients with HF.
Methods: A tot..
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Gastroenterology / Original Article
Usefulness of nasal cavity evaluation before high-resolution esophageal manometry in high-risk patients
Hyun Jin Min, Jae Yong Park
Korean J Intern Med. 2024;39(1):86-94. Published online November 30, 2023
Background/Aims: A catheter is inserted through the nasal cavity during high-resolution esophageal manometry (HRM), which may cause adverse events such as pain or epistaxis. Despite these possible safety considerations, studies on this subject are very limited. We aimed to investigate the usefulness..
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Gastroenterology / Original Article
Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity
Seung Yong Shin, Hee Sung Kim, Kisung Kim, Chang Won Choi, Jung Min Moon, Jeong Wook Kim, Hyun Jin Joo, Jeongkuk Seo, Muhyeon Sung, Chang Hwan Choi
Korean J Intern Med. 2024;39(1):68-76. Published online December 13, 2023
Background/Aims: We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH).
Methods: We prospectively collected and reviewed data from patients with UC who..
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Hemato-oncology / Review
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
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Pulmonology / Original Article
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Cardiology / Original Article
Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
Ki-Woon Kang, Kyung-Won Hong, Seong-Kyu Lee
Korean J Intern Med. 2023;38(6):865-871. Published online November 1, 2023
Background/Aims: Scrub typhus infection has been known to complicate cardiovascular diseases mainly attributing to high mortality. Genetic susceptibility loci for complicating cardiac diseases such as atrial fibrillation, heart failure, and ischemic heart disease identified by genomic study have bee..
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Gastroenterology / Original Article
Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate
Young Cheol Shin, Eun Ju Cho, Hee Young Na, Jai Young Cho, Ho-Seong Han, Yoon Jin Lee, Haeryoung Kim, Sangmi Jang, Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Korean J Intern Med. 2023;38(6):818-830. Published online November 1, 2023
Background/Aims: There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors.
Methods: A retrospective case-control study of patients treated in 2 centers..
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Pulmonology / Review
Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Jae Kyeom Sim, Juwhan Choi, Sung Yong Lee
Korean J Intern Med. 2023;38(6):787-796. Published online November 1, 2023
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm of lung cancer treatment. Recently, ICIs are expanding their ..
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Gastroenterology / Original Article
Diagnosis and management of acute colonic diverticulitis: results of a survey among Korean gastroenterologists
Jae Gon Lee, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Shin Hee Lee, Myung-Won You, Seong-Eun Kim
Korean J Intern Med. 2023;38(5):672-682. Published online August 17, 2023
Background/Aims: Some management strategies for acute colonic diverticulitis remain controversial in Korean real-world practice because their clinical features differ from those in the West. This study aimed to investigate the opinions of Korean physicians regarding the diagnosis and treatment of ac..
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Gastroenterology / Original Article
Efficacy and safety of 1 L polyethylene glycol plus ascorbic acid for bowel preparation in elderly: comparison with oral sulfate solution
Ki Young Lim, Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang; on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Korean J Intern Med. 2023;38(5):651-660. Published online July 24, 2023
Background/Aims: Recently, 1 L of polyethylene glycol (PEG) plus ascorbic acid (Asc) has been introduced in Korea as a colonoscopy preparation agent. Data on its efficacy and safety in older adults have been limited. We aimed to evaluate the safety and efficacy of 1 L PEG/Asc in older adults by comp..
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Cardiology / Review
Role of cardiac imaging in management of heart failure
So Ree Kim, Seong-Mi Park
Korean J Intern Med. 2023;38(5):607-619. Published online August 29, 2023
The significant advancement in cardiac imaging in recent years led to improved diagnostic accuracy in identifying the specific causes of heart failure and also provided physicians with guidelines for appropriately managing patients with heart failure. Diseases that were once considered rare are now ..
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Geriatrics / Original Article
Predictors of 3-month mortality with muscle ultrasound and palliative prognostic tools among patients admitted to palliative care units
Zeynep Irmak Kaya, Yelda Öztürk, Sinem Gürcü, Gülgün Uncu, Anıl Uçan, Mert Eşme, Berrin Yalınbaş Kaya, Cafer Balci
Korean J Intern Med. 2023;38(4):557-565. Published online March 31, 2023
Background/Aims: Prognostic factors are an important issue in progressive and life-limiting diseases. This study evaluate 3-month mortality in patients admitted to the palliative care unit (PCU).
Methods: In this study, the patient’s demographics, comorbidities, nutritional status, and laboratory..
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Cardiology / Review
Role of echocardiography in acute pulmonary embolism
Jin Kyung Oh, Jae-Hyeong Park
Korean J Intern Med. 2023;38(4):456-470. Published online January 2, 2023
Although pulmonary embolism (PE)-related mortality rate has decreased because of prompt diagnosis and effective therapy use, acute PE remains a potentially lethal disease. Due to its increasing prevalence, clinicians should pay attention to diagnosing and managing patients with acute PE. Echocardiog..
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Gastroenterology / Original Article
Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
Korean J Intern Med. 2023;38(3):349-361. Published online March 27, 2023
Background/Aims: Some sessile serrated lesions (SSLs) progress into dysplasia and colorectal cancer, however, the clinical and endoscopic characteristics of SSLs with dysplasia remain to be determined. In this study, we elucidated these characteristics in SSLs with dysplasia/carcinoma, compared with..
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Geriatrics / Original Article
The prognostic value of comprehensive geriatric assessment on the management of older patients with small cell lung cancer
You Jin Chun, Kwang Joon Kim, Ji Yeon Lee, Ji Won Choi, Tae Hee Kim, Hye Ryun Kim, Byoung Chul Cho, Min Hee Hong, Chang Oh Kim
Korean J Intern Med. 2023;38(2):254-263. Published online January 19, 2023
Background/Aims: The prognostic value of a comprehensive geriatric assessment (CGA) for the management of older small cell lung cancer (SCLC) patients remains to be established.
Methods: A retrospective cohort enrolled 21 SCLC patients over 65 years from March 2018 to 2019 at the Yonsei Cancer Cent..
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