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Letter to the editor
Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient
Young Jae Park, Hyun Jin Bae, Ji-Yeun Chang, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2017;32(4):750-752. Published online February 4, 2016
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Hemato-oncology / Original Article
Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
Junghoon Shin, Youngil Koh, Jeonghwan Youk, Miso Kim, Byung Soo Kim, Chul Won Choi, Hwa Jung Sung, Yong Park, Sung-Soo Yoon, Inho Kim
Korean J Intern Med. 2017;32(4):722-730. Published online June 26, 2017
Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.
Methods: We reviewed the medical records of MM patients whose age was 40 ..
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Nephrology / Original Article
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
Korean J Intern Med. 2017;32(3):505-513. Published online March 25, 2016
Background/Aims: There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vi..
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Nephrology / Original Article
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
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Hemato-oncology / Original Article
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Endocrinology-metabolism / Review
Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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Letter to the editor
Pulmonary graft-versus-host disease after autologous hematopoietic stem cell transplantation
Sue In Choi, Eun Joo Lee, Dong Oh Kang, Sang Yeub Lee, Kwang Ho In, Han-Kyeom Kim, Sanghoon Park
Korean J Intern Med. 2016;31(6):1181-1183. Published online December 23, 2015
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Letter to the editor
A confusing case of multiple sclerosis and central nervous system graft versus host disease
Byung-Nam Yoon, Choong Kun Ha, Kwang-Woo Lee, Sung-Hye Park, Jung-Joon Sung
Korean J Intern Med. 2016;31(5):995-998. Published online February 3, 2016
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Infectious diseases / Original Article
Differences of cytomegalovirus diseases between kidney and hematopoietic stem cell transplant recipients during preemptive therapy
Tark Kim, Yu-Mi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Heungsup Sung, Joo Hee Jung, Sung Shin, Young Hoon Kim, Young-Ah Kang, Young-Shin Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Su-Kil Park, Duck Jong Han, Sung-Han Kim
Korean J Intern Med. 2016;31(5):961-970. Published online April 8, 2016
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and..
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Hemato-oncology / Original Article
Does anti-thymocyte globulin have a place in busulfan/fludarabine conditioning for matched related donor hematopoietic stem cell transplantation?
Young Sok Ji, Min Sung Lee, Chang Wook Min, Seong Kyu Park, Se Hyung Kim, Jina Yun, Hyun Jung Kim, Kyoung Ha Kim, Chan Kyu Kim, Kyu-Taek Lee, Jong-Ho Won, Dae Sik Hong
Korean J Intern Med. 2016;31(4):750-761. Published online March 28, 2016
Background/Aims: There is controversy about the prophylactic effect of anti-thymocyte globulin (ATG) on graft versus host disease (GVHD) in the setting of matched related-donor hematopoietic stem cell transplantation (HSCT). This study assessed the inf luences of ATG on the incidences of acute and c..
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Nephrology / Original Article
Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors
Ji Hyun Yu, Kyoung Woon Kim, Bo-Mi Kim, Byung Ha Chung, Mi-La Cho, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
Korean J Intern Med. 2016;31(3):552-559. Published online March 11, 2016
Background/Aims: Sirolimus (SRL) is a promising immunosuppressant replacingcalcineurin inhibitors (CNIs). This study was performed to evaluate the safetyand immunologic benefits of conversion to SRL in stable kidney transplant (KT)recipients exposed to CNIs for long periods.
Methods: Fourteen CNI-t..
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Nephrology / Original Article
Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients
Hae Min Lee, In-Ae Jang, Dongjae Lee, Eun Jin Kang, Bum Soon Choi, Cheol Whee Park, Yeong Jin Choi, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(6):865-872. Published online October 30, 2015
Background/Aims: BK virus-associated nephropathy (BKVAN) is an important cause of allograft dysfunction in kidney transplant recipients. It has an unfavorable clinical course, and no definite treatment guidelines have yet been established. Here, we report our center’s experience with biopsy-proven ..
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Nephrology / Review
Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation
Sun Woo Lim, Ji Zhe Jin, Long Jin, Jian Jin, Can Li
Korean J Intern Med. 2015;30(6):759-770. Published online October 30, 2015
Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall..
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Letter to the editor
Limited immune tolerance induced by transient mixed chimerism
Ji Hyun Yu, Byung Ha Chung, Eun Ji Oh, Ji-Il Kim, Hee-Je Kim, In Sung Moon, Chul Woo Yang
Korean J Intern Med. 2015;30(5):735-738. Published online August 27, 2015
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Infectious diseases / Original Article
Clinical significance of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci colonization in liver transplant recipients
Youn Jeong Kim, Sang Il Kim, Jong Young Choi, Seung Kyu Yoon, Young-Kyoung You, Dong Goo Kim
Korean J Intern Med. 2015;30(5):694-704. Published online August 27, 2015
Background/Aims: Liver transplant patients are at high risk for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) colonization. We evaluated patients before and after liver transplant using active surveillance culture (ASC) to assess the prevalence ..
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Nephrology / Original Article
Immunologic and non-immunologic complications of a third kidney transplantation
Hyun Seon Kim, Jae Young Kim, Eun Jin Kang, Yoon Seok Choi, Ji-Il Kim, In Sung Moon, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(5):657-664. Published online August 27, 2015
Background/Aims: Patients who undergo repeat kidney transplantations (KTs) are considered at high risk for experiencing immunologic and non-immunologic complications. In this study, we investigated the clinical outcomes, including medical and surgical complications, of patients who underwent a third..
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Infectious diseases / Original Article
Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies
Ji Hyun Yun, Sang-Oh Lee, Kyung-Wook Jo, Se Hoon Choi, Jina Lee, Eun Jin Chae, Kyung-Hyun Do, Dae-Kee Choi, In-Cheol Choi, Sang-Bum Hong, Tae Sun Shim, Hyeong Ryul Kim, Dong Kwan Kim, Seung-Il Park
Korean J Intern Med. 2015;30(4):506-514. Published online June 29, 2015
Background/Aims: Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our instituti..
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Hemato-oncology / Original Article
Role of frontline autologous stem cell transplantation in young, high-risk diffuse large B-cell lymphoma patients
Jae-Ho Yoon, Jong-Wook Kim, Young-Woo Jeon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Jong-Wook Lee, Woo-Sung Min, Chong-Won Park, Seok-Goo Cho
Korean J Intern Med. 2015;30(3):362-371. Published online April 29, 2015
Background/Aims: Several studies have demonstrated the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) as a salvage treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL). However, the role of auto-HSCT as a frontline treatment has not been fully investig..
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Hemato-oncology / Review
Recent advances in treatment of aplastic anemia
Seung Hwan Shin, Sung Eun Lee, Jong Wook Lee
Korean J Intern Med. 2014;29(6):713-726. Published online October 31, 2014
Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT) is a preferred first-line treatment option for younger patients with severe or very severe AA,..
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Hemato-oncology / Original Article
Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation
Joo Han Park, Hyo Jung Lee, Sei Rhan Kim, Ga Won Song, Seung Kyong Lee, Sun Young Park, Ki Chan Kim, Sun Hyuk Hwang, Joon Seong Park
Korean J Intern Med. 2014;29(5):630-636. Published online August 28, 2014
Background/Aims: The treatment for steroid-refractory acute graft versus host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) needs to be standardized. We report our clinical experience with etanercept for steroid-refractory acute GVHD.
Methods: Eighteen patients who underwent ..
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