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Rheumatology / Original Article
Predictors of renal relapse in Koreans with lupus nephritis after achieving complete response: a 35-years of experience at a single center
Howook Jeon, Jennifer Lee, Su-Jin Moon, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2024;39(2):347-359. Published online January 22, 2024
Background/Aims: Renal relapse has known to be a poor prognostic factor in patients with lupus nephritis (LN), but there were few studies that identified the risk factors of renal relapse in real world. We conducted this study based on 35-years of experience at a single center to find out predictors..
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Hemato-oncology / Original Article
Prognostic Significance Of Sequential 18f-fdg Pet/Ct During Frontline Treatment Of Peripheral T Cell Lymphomas
Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Mihee Kim, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang
Korean J Intern Med. 2024;39(2):327-337. Published online January 25, 2024
Background/Aims: The prognostic significance of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential 18F-FDG PET/CT during frontline chemo..
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Allergy / Review
New targets for type 2-low asthma
Quang Luu Quoc, Youngwoo Choi, Gyu-Young Hur, Hae-Sim Park
Korean J Intern Med. 2024;39(2):215-227. Published online February 6, 2024
Asthma is characterized by airway obstruction and inflammation, and presents significant diagnostic and treatment challenges. The concept of endotypes has improved understanding of the mechanisms of asthma and has stimulated the development of effective treatment strategies. Sputum profiles may be u..
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Rheumatology / Original Article
Characteristics of patients with psoriatic arthritis in Korea: focusing on axial involvement
Hanna Park, Ji Hyun Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park, Jennifer Jooha Lee
Korean J Intern Med. 2024;39(1):184-193. Published online December 8, 2023
Background/Aims: We aimed to clarify the clinical characteristics of psoriatic arthritis (PsA) in Korean patients focusing on PsA with axial involvement.
Methods: A retrospective medical chart review was performed to identify PsA patients at a single tertiary center. Cases of AS patients with psori..
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Hemato-oncology / Review
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
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Rheumatology / Original Article
Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
Mie Jin Lim, Kyong-Hee Jung, Seong-Ryul Kwon, Won Park
Korean J Intern Med. 2023;38(6):912-922. Published online October 23, 2023
Background/Aims: We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA).
Methods: Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab. If RA became active for > 6 months after the first ritux..
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Hemato-oncology / Original Article
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
Korean J Intern Med. 2023;38(6):893-902. Published online August 21, 2023
Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge.
Methods: We developed a rituximab-resistant cell line (RRCL) by sequential exposure to gradually increasi..
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Cardiology / Original Article
Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
Ki-Woon Kang, Kyung-Won Hong, Seong-Kyu Lee
Korean J Intern Med. 2023;38(6):865-871. Published online November 1, 2023
Background/Aims: Scrub typhus infection has been known to complicate cardiovascular diseases mainly attributing to high mortality. Genetic susceptibility loci for complicating cardiac diseases such as atrial fibrillation, heart failure, and ischemic heart disease identified by genomic study have bee..
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Gastroenterology / Original Article
Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
Young Hoon Choi, Younggyun Lim, Dong Kee Jang, Dong-Won Ahn, Ji Kon Ryu, Woo Hyun Paik, Yong-Tae Kim, Ju Han Kim, Sang Hyub Lee
Korean J Intern Med. 2023;38(6):854-864. Published online October 23, 2023
Background/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about this yet. The aim of this study was to identify genetic variati..
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Gastroenterology / Original Article
Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis
Younghee Choe, Jae Myung Park, Joon Sung Kim, Yu Kyung Cho, Byung-Wook Kim, Myung-Gyu Choi
Korean J Intern Med. 2023;38(6):831-843. Published online November 1, 2023
Background/Aims: Metachronous gastric cancer (MGC) can occur after endoscopic resection for gastric cancer. Further studies on factors other than Helicobacter pylori infection are needed. This systematic review and meta-analysis aimed to evaluate risk factors for metachronous recurrence of en..
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Rheumatology / Original Article
Long-term renal outcomes of patients with non-proliferative lupus nephritis
Eun-Song Kang, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Korean J Intern Med. 2023;38(5):769-776. Published online August 7, 2023
Background/Aims: Although non-proliferative lupus nephritis (LN) (class I, II or V) has been considered as a less severe type of LN, data on long-term renal prognosis are limited. We investigated the long-term outcomes and prognostic factors in non-proliferative LN.
Methods: We retrospectively revi..
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Hemato-oncology / Original Article
Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06)
Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi
Korean J Intern Med. 2023;38(5):747-757. Published online June 26, 2023
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL.
Methods: A t..
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Hemato-oncology / Original Article
Rituximab plus multiagent chemotherapy for newly diagnosed CD20-positive acute lymphoblastic leukemia: a prospective phase II study
Dong Won Baek, Han-Seung Park, Sang Kyun Sohn, Dae Young Kim, Inho Kim, Jae-Sook Ahn, Young Rok Do, Se Ryeon Lee, Hyeon-Seok Eom, Won-Sik Lee, Sung-Hyun Kim, Ho Sup Lee, Yoo Jin Lee, Joon Ho Moon, Je-Hwan Lee; Adult Acute Lymphoblastic Leukemia Working Party, the Korean Society of Hematology
Korean J Intern Med. 2023;38(5):734-746. Published online June 20, 2023
Background/Aims: We performed a prospective study to determine the efficacy and safety of rituximab including chemotherapy in CD20-positive acute lymphoblastic leukemia (ALL).
Methods: Patients with newly diagnosed ALL, aged ≥ 15 years, were eligible for the study if their leukemic blast cells in ..
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Nephrology / Original Article
Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease
Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2023;38(5):725-733. Published online August 17, 2023
Background/Aims: The neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not b..
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Cardiology / Review
Role of cardiac imaging in management of heart failure
So Ree Kim, Seong-Mi Park
Korean J Intern Med. 2023;38(5):607-619. Published online August 29, 2023
The significant advancement in cardiac imaging in recent years led to improved diagnostic accuracy in identifying the specific causes of heart failure and also provided physicians with guidelines for appropriately managing patients with heart failure. Diseases that were once considered rare are now ..
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Geriatrics / Original Article
Predictors of 3-month mortality with muscle ultrasound and palliative prognostic tools among patients admitted to palliative care units
Zeynep Irmak Kaya, Yelda Öztürk, Sinem Gürcü, Gülgün Uncu, Anıl Uçan, Mert Eşme, Berrin Yalınbaş Kaya, Cafer Balci
Korean J Intern Med. 2023;38(4):557-565. Published online March 31, 2023
Background/Aims: Prognostic factors are an important issue in progressive and life-limiting diseases. This study evaluate 3-month mortality in patients admitted to the palliative care unit (PCU).
Methods: In this study, the patient’s demographics, comorbidities, nutritional status, and laboratory..
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Cardiology / Review
Role of echocardiography in acute pulmonary embolism
Jin Kyung Oh, Jae-Hyeong Park
Korean J Intern Med. 2023;38(4):456-470. Published online January 2, 2023
Although pulmonary embolism (PE)-related mortality rate has decreased because of prompt diagnosis and effective therapy use, acute PE remains a potentially lethal disease. Due to its increasing prevalence, clinicians should pay attention to diagnosing and managing patients with acute PE. Echocardiog..
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Cardiology / Original Article
Influence of an abnormal ankle-brachial index on ischemic and bleeding events in patients undergoing percutaneous coronary intervention
Hangyul Kim, Seung Do Lee, Hyo Jin Lee, Hye Ree Kim, Kyehwan Kim, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong-Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Min Gyu Kang
Korean J Intern Med. 2023;38(3):372-381. Published online April 20, 2023
Background/Aims: Bleeding events after percutaneous coronary intervention (PCI) have important prognostic implications. Data on the influence of an abnormal ankle-brachial index (ABI) on both ischemic and bleeding events in patients undergoing PCI are limited.
Methods: We included patients who unde..
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Gastroenterology / Original Article
Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study
Kyung Min Kwon, Jae-Jun Shim, Gi-Ae Kim, Bo Ok Kim, Helin Han, Hyun Jung Ahn
Korean J Intern Med. 2023;38(3):338-348. Published online April 10, 2023
Background/Aims: Chronic hepatitis C (CHC) is the second leading cause of liver-related mortality and is more prevalent in the elderly population in Korea. Decisions to initiate treatment and selection of proper antiviral agents may be challenging among elderly patients due to relevant comorbidities..
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Hemato-oncology / Original Article
Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma
[corrected-article]
Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon
Korean J Intern Med. 2023;38(2):238-247. Published online January 26, 2023
Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for pre..
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