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Nephrology / Original Article
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Nephrology / Original Article
Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Nephrology / Original Article
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection
Sun Chul Kim, Min Young Seo, Jun Yong Lee, Ki Tae Kim, Eunjung Cho, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho, Hyoung-Kyu Kim
Korean J Intern Med. 2016;31(1):125-133. Published online December 28, 2015
Background/Aims: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C. difficile. However, recent studies of the clinical impact of CKD on CDI in Asia..
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Gastroenterology / Original Article
Feasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea
Dae Geon Ahn, Hyung Joon Kim, Hyun Kang, Hyun Woong Lee, Si Hyun Bae, Joon Hyoek Lee, Yong Han Paik, June Sung Lee
Korean J Intern Med. 2016;31(1):46-53. Published online December 28, 2015
Background/Aims: The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients.
Methods: We retrospectively reviewed the medical records of HCC and cirrhosis patients at three hospitals. For each HCC patient..
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Nephrology / Original Article
The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells
Samel Park, Il-woong Hwang, Jin-sheon Kim, Hyo-chul Kang, Su-Yeon Park, Hyo-wook Gil, Ho-yeon Song, Sae-yong Hong
Korean J Intern Med. 2015;30(6):873-883. Published online October 30, 2015
Background/Aims: Most pesticide formulations contain both chief and additive ingredients. But, the additives may not have been tested as thoroughly as the chief ingredients. The surfactant, nonyl phenoxypolyethoxylethanol (NP40), is an additive frequently present in pesticide formulations. We invest..
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Hemato-oncology / Original Article
Clinical characteristics and outcomes in diffuse large B cell lymphoma patients aged 70 years and older: a single-center experience with a literature review
Yun Hwa Jung, In Sook Woo, Chi Wha Han
Korean J Intern Med. 2015;30(5):684-693. Published online August 27, 2015
Background/Aims: Among diffuse large B cell lymphoma (DLBCL) patients, determining the appropriate dose and chemotherapy schedule to balance toxicity and efficacy is harder in elderly than in younger patients. Moreover, there are no currently available clinical factors that consistently identify pat..
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Rheumatology / Original Article
Predictive factors of radiographic progression in ankylosing spondylitis
Hyungjin Kim, Jaejoon Lee, Joong Kyong Ahn, Jiwon Hwang, Eun-Jung Park, Hyemin Jeong, Hoon-Suk Cha, Eun-Mi Koh
Korean J Intern Med. 2015;30(3):391-397. Published online April 29, 2015
Background/Aims: The course of ankylosing spondylitis (AS) is rather variable, and the factors that predict radiographic progression remain largely obscure. In this study, we tried to determine the clinical factors and laboratory measures that are useful in predicting the radiographic progression of..
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Nephrology / Original Article
Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Ga-Young Park, Chung-Hoon Yu, Jun-Seop Kim, Yun-Jeong Kang, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2015;30(3):345-353. Published online April 29, 2015
Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).
Methods: In total, 91 patients with biopsy-proven IgAN ..
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Gastroenterology / Original Article
Long-term outcomes of balloon dilation versus botulinum toxin injection in patients with primary achalasia
Ho Eun Jung, Joon Seong Lee, Tae Hee Lee, Jin Nyoung Kim, Su Jin Hong, Jin Oh Kim, Hyeon Geon Kim, Seong Ran Jeon, Joo Young Cho
Korean J Intern Med. 2014;29(6):738-745. Published online October 31, 2014
Background/Aims: We compared the long-term outcomes of balloon dilation versus botulinum toxin injection in Korean patients with primary achalasia and identified factors predicting remission.
Methods: We included 73 patients with achalasia newly diagnosed between January 1988 and January 2011. We u..
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Endocrinology-metabolism / Original Article
The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Ohk-Hyun Ryu, Wankyo Chung, Sungwha Lee, Kyung-Soon Hong, Moon-Gi Choi, Hyung Joon Yoo
Korean J Intern Med. 2014;29(5):620-629. Published online August 28, 2014
Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular ris..
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Nephrology / Original Article
Ferritin as a predictor of decline in residual renal function in peritoneal dialysis patients
Soon Mi Hur, Hye Young Ju, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang
Korean J Intern Med. 2014;29(4):489-497. Published online June 27, 2014
Background/Aims: Inflammation is an important factor in renal injury. Ferritin, an inflammatory marker, is considered an independent predictor of rapid renal progression in patients with chronic kidney disease. However, the relationship between ferritin and residual renal function (RRF) in patients ..
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Nephrology / Review
Vitamin D and chronic kidney disease
Chang Seong Kim, Soo Wan Kim
Korean J Intern Med. 2014;29(4):416-427. Published online June 27, 2014
Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse cor..
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Nephrology / Original Article
A mild decrease of renal function is related to increased hemoglobin level during 5-year follow-up period
Nara Shin, Hyunsuk Kim, Hyo Jin Kim, Miyeun Han, Sunhwa Lee, Hyungah Jo, Huh Hyuk, Ho Jun Chin
Korean J Intern Med. 2014;29(3):341-351. Published online April 29, 2014
Background/Aims: We analyzed chronological changes in hemoglobin according to renal function changes over a 5-year follow-up period.
Methods: We enrolled 5,266 adults with a glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 at an initial examination at a routine heal..
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Case Report
Ifosfamide-induced Fanconi syndrome with diabetes insipidus
Ah Young Leem, Han Sang Kim, Byung Woo Yoo, Beo Deul Kang, Min Hwan Kim, Sun Young Rha, Hyo Song Kim
Korean J Intern Med. 2014;29(2):246-249. Published online February 27, 2014
Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40–60 g/m2, a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied by type II ..
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Endocrinology-metabolism / Original Article
Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome
Jung Hee Kim, Hyun Wook Baik, Yeong Sook Yoon, Hyo Jee Joung, Ju Sang Park, Sang Jong Park, Eun Jeong Jang, Sang Woon Park, Sang Jung Kim, Mi Jeoung Kim, Dong Ok Jeon, Hyo Jin Cho, Sang Jin Lee, Sung Gyu Im, Sun Kyung Jang
Korean J Intern Med. 2014;29(1):31-39. Published online January 2, 2014
Background/Aims: Oxidative stress increases the risk of cardiovascular complications
of metabolic syndrome (MetS). This study was conducted to examine the
difference in antioxidant capacity according to the presence of MetS, and to characterize
the association between antioxidant capacity and Me..
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Acute respiratory failure caused by phenytoin overdose
Chang Kyung Kang, Min-Kyung Kim, Min Jae Kim, Kang Il Jun, Ki Woong Kim, Seong-Ho Park, Kyoung-Ho Song
Korean J Intern Med. 2013;28(6):736-738. Published online October 29, 2013
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Letter to the editor
Acute regional myocarditis with normal ventricular wall motion diagnosed by two-dimensional speckle tracking imaging
Sang Jin Ha, Jong Shin Woo, Se Hwan Kwon, Chi Hyuk Oh, Kwon Sam Kim, Jong-Hoa Bae, Woo-Shik Kim
Korean J Intern Med. 2013;28(6):732-735. Published online October 29, 2013
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Case Report
Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype
Dong Hee Han, In Ho Moh, Doo-Man Kim, Sung Hee Ihm, Moon-Gi Choi, Hyung Joon Yoo, Eun-Gyoung Hong
Korean J Intern Med. 2013;28(5):609-613. Published online August 14, 2013
We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in the presence of the apolipoprotein E3/2 genotype. This is the first reported case of extr..
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Endocrinology-metabolism / Original Article
Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome
Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung
Korean J Intern Med. 2013;28(4):456-463. Published online July 1, 2013
Background/AimsMany women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor bin..
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Gastroenterology / Original Article
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
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