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Gastroenterology / Original Article
Investigation of pulmonary involvement in inflammatory bowel disease in an experimental
model of colitis
Bunyamin Aydin, Yıldıran Songur, Necla Songur, Oğuzhan Aksu, Altug Senol, I. Metin Ciris, Recep Sutcu
Korean J Intern Med. 2016;31(5):853-859. Published online August 19, 2016
Background/Aims: Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental..
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Pulmonology / Original Article
Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment
response
Sung-Jin Nam, Jee-Yeong Jeong, Tae-Won Jang, Mann-Hong Jung, Bong-Kwon Chun, Hee-Jae Cha, Chul-Ho Oak
Korean J Intern Med. 2016;31(4):694-702. Published online June 3, 2016
Background/Aims: It is not clear which tests are indicative of the activity and severity of tuberculosis (TB). This study aimed to investigate the predictive value of neuron-specific enolase (NSE) and to determine the origin of NSE in TB patients.
Methods: A single-center retrospective analysis was..
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Pulmonology / Original Article
A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
Sun Hyo Park, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee, Hee Jin Kim, Dick Menzies
Korean J Intern Med. 2016;31(3):517-524. Published online April 7, 2016
Background/Aims: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea.
Methods: Adult close contacts of active pulmonary TB patients were recruited ..
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Pulmonology / Original Article
Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
So Young Park, Sang Min Lee, Jong Wook Shin, Byoung Whui Choi, Hojoong Kim, Jae Seung Lee, Sang Do Lee, Sung Soo Park, Hwa Sik Moon, Yong Bum Park
Korean J Intern Med. 2016;31(2):305-312. Published online January 29, 2016
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o..
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Pulmonology / Original Article
Survival benefits of warfarin in Korean patients with idiopathic pulmonary arterial hypertension
Byung Ju Kang, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2015;30(6):837-845. Published online October 30, 2015
Background/Aims: Idiopathic pulmonary arterial hypertension (IPAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for IPAH, the benefits are uncertain, particularly in Korea, where it has not been studied. The purpose of this study was to evalu..
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Pulmonology / Original Article
Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
Chang-Hoon Lee, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2015;30(5):629-637. Published online August 27, 2015
Background/Aims: In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical ..
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Pulmonology / Review
Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Pulmonology / Original Article
Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center
Ho Young Lee, Jin Lee, Young Seok Lee, Mi-Yeong Kim, Hyun-Kyung Lee, Young-Min Lee, Jeong Hwan Shin, Yousang Ko
Korean J Intern Med. 2015;30(3):325-334. Published online April 29, 2015
Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
Methods: All patients..
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Rheumatology / Original Article
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival
Hong Ki Min, Jae Ho Lee, Seung Min Jung, Jennifer Lee, Kwi Young Kang, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(2):232-241. Published online February 27, 2015
Background/Aims: We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival.
Methods: This retrospective single-center study included 154..
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Pulmonology / Original Article
Awareness of chronic obstructive pulmonary disease in current smokers: a nationwide survey
So Yeong Mun, Yong Il Hwang, Joo Hee Kim, Sunghoon Park, Seung Hun Jang, Jae Yong Seo, Ja Kyung Kim, Yong Bum Park, Jae Jung Shim, Ki-Suck Jung
Korean J Intern Med. 2015;30(2):191-197. Published online February 27, 2015
Background/Aims: Cigarette smoking is the most common risk factor for chronic obstructive pulmonary disease (COPD). However, few studies of the attitudes toward COPD of smokers, the group at risk of developing this condition, have been conducted. The purpose of this study was to explore the awarenes..
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Pulmonology / Original Article
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Pulmonology / Original Article
Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis
Ki-Eun Hwang, Hyo-Yeop Song, Jae-Wan Jung, Su-Jin Oh, Kwon-Ha Yoon, Do-Sim Park, Eun-Taik Jeong, Hak-Ryul Kim
Korean J Intern Med. 2015;30(1):56-61. Published online December 30, 2014
Background/Aims: Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated the specific clinical and pleural fluid features of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis.
Methods: We retro..
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Cardiology / Original Article
The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity
In Sook Kang, Kyung Jin Kim, Yookyung Kim, Seong-Hoon Park
Korean J Intern Med. 2014;29(6):746-753. Published online October 31, 2014
Background/Aims: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate the feasibility of chest computed tomography (CT) as a diagnostic tool for APT and to ..
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Pulmonology / Original Article
The effects of secondhand smoke on chronic obstructive pulmonary disease in nonsmoking Korean adults
Woong Jun Kim, June Seok Song, Dong Won Park, Hyun Jung Kwak, Ji-Yong Moon, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park, Tae-Hyung Kim
Korean J Intern Med. 2014;29(5):613-619. Published online August 28, 2014
Background/Aims: Smoking is widely acknowledged as the single most important risk factor for chronic obstructive pulmonary disease (COPD). However, the risk of COPD in nonsmokers exposed to secondhand smoke remains controversial. In this study, we investigated the association of secondhand smoke exp..
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Pulmonology / Original Article
Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
Seo Woo Kim, Jin Hwa Lee, Yun Su Sim, Yon Ju Ryu, Jung Hyun Chang
Korean J Intern Med. 2014;29(4):466-473. Published online June 27, 2014
Background/Aims: Gastroesophageal reflux disease is one of the most common causes of chronic cough and is a potential risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors for reflux esophagitis (RE)..
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Pulmonology / Review
Modifiers of TGF-b1 effector function as novel therapeutic targets of pulmonary fibrosis
Chang-Min Lee, Jin Wook Park, Won-Kyung Cho, Yang Zhou, Boram Han, Pyoung Oh Yoon, Jeiwook Chae, Jack A Elias, Chun Geun Lee
Korean J Intern Med. 2014;29(3):281-290. Published online April 29, 2014
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-b1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs including skin, liver, kidney, and lung. Thus, TGF-b1 and its signaling pathways have been at..
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Rheumatology / Original Article
Meta-analysis of randomized controlled trials of bosentan for treatment of pulmonary arterial hypertension
Young Ho Lee, Gwan Gyu Song
Korean J Intern Med. 2013;28(6):701-707. Published online October 29, 2013
Background/AimsWe assessed the efficacy and safety of bosentan in patients with pulmonary arterial hypertension (PAH). MethodsWe surveyed randomized controlled trials (RCTs) of the efficacy and safety of bosentan in patients with PAH using MEDLI..
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Letter to the editor
Aortic intramural hematoma after thrombolysis in a patient with acute massive pulmonary embolism
Min Su Kim, Kyu Seop Kim, Il Soon Jung, Jae-Hyeong Park, Jin-Ok Jeong, Si Wan Choi, In-Whan Seong
Korean J Intern Med. 2013;28(5):619-621. Published online August 14, 2013
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Case Report
A case of secondary syphilis presenting as multiple pulmonary nodules
Se Joong Kim, Ju-Han Lee, Eung-Seok Lee, Il-Hwan Kim, Hyung Joo Park, Chol Shin, Je Hyeong Kim
Korean J Intern Med. 2013;28(2):231-235. Published online February 27, 2013
Syphilis is a sexually transmitted disease caused by Treponema pallidum. The prevalence of this disease has recently increased worldwide. However, pulmonary involvement in secondary syphilis is extremely rare. A 51-year-old heterosexual male patient presented with multiple pulmon..
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Letter to the editor
Pulmonary thromboembolism due to severe hyperhomocysteinemia associated with a methyltetrahydrofolate reductase mutation
Kyung Hoon Cho, Myung Ho Jeong, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jung Chaee Kang
Korean J Intern Med. 2013;28(1):112-115. Published online December 28, 2012
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