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Endocrinology-metabolism / Original Article
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis
Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim
Korean J Intern Med. 2024;39(1):148-159. Published online December 22, 2023
Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications.
Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..
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Cardiology / Original Article
Time to presentation and mortality outcomes among patients with diabetes and acute myocardial infarction
Min-A Shin, Seok Oh, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong
Korean J Intern Med. 2024;39(1):110-122. Published online December 11, 2023
Background/Aims: Due to limited real-world evidence on the association between time to presentation (T2P) and outcomes following acute myocardial infarction and diabetes (AMI-DM), we investigated the characteristics of patients with AMI-DM and their outcomes based on their T2P.
Methods: 4,455 patie..
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Gastroenterology / Original Article
Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity
Seung Yong Shin, Hee Sung Kim, Kisung Kim, Chang Won Choi, Jung Min Moon, Jeong Wook Kim, Hyun Jin Joo, Jeongkuk Seo, Muhyeon Sung, Chang Hwan Choi
Korean J Intern Med. 2024;39(1):68-76. Published online December 13, 2023
Background/Aims: We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH).
Methods: We prospectively collected and reviewed data from patients with UC who..
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Hemato-oncology / Review
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
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Rheumatology / Original Article
Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
Mie Jin Lim, Kyong-Hee Jung, Seong-Ryul Kwon, Won Park
Korean J Intern Med. 2023;38(6):912-922. Published online October 23, 2023
Background/Aims: We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA).
Methods: Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab. If RA became active for > 6 months after the first ritux..
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Gastroenterology / Original Article
Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
Young Hoon Choi, Younggyun Lim, Dong Kee Jang, Dong-Won Ahn, Ji Kon Ryu, Woo Hyun Paik, Yong-Tae Kim, Ju Han Kim, Sang Hyub Lee
Korean J Intern Med. 2023;38(6):854-864. Published online October 23, 2023
Background/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about this yet. The aim of this study was to identify genetic variati..
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Hemato-oncology / Review
Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms
Seug Yun Yoon, Sung-Yong Kim
Korean J Intern Med. 2023;38(6):810-817. Published online November 1, 2023
Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. The progression of MPNs follows a biolog..
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Pulmonology / Review
Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Jae Kyeom Sim, Juwhan Choi, Sung Yong Lee
Korean J Intern Med. 2023;38(6):787-796. Published online November 1, 2023
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm of lung cancer treatment. Recently, ICIs are expanding their ..
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Hemato-oncology / Original Article
Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06)
Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi
Korean J Intern Med. 2023;38(5):747-757. Published online June 26, 2023
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL.
Methods: A t..
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Nephrology / Original Article
Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease
Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2023;38(5):725-733. Published online August 17, 2023
Background/Aims: The neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not b..
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Gastroenterology / Original Article
Efficacy and safety of 1 L polyethylene glycol plus ascorbic acid for bowel preparation in elderly: comparison with oral sulfate solution
Ki Young Lim, Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang; on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Korean J Intern Med. 2023;38(5):651-660. Published online July 24, 2023
Background/Aims: Recently, 1 L of polyethylene glycol (PEG) plus ascorbic acid (Asc) has been introduced in Korea as a colonoscopy preparation agent. Data on its efficacy and safety in older adults have been limited. We aimed to evaluate the safety and efficacy of 1 L PEG/Asc in older adults by comp..
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Cardiology / Review
Role of cardiac imaging in management of heart failure
So Ree Kim, Seong-Mi Park
Korean J Intern Med. 2023;38(5):607-619. Published online August 29, 2023
The significant advancement in cardiac imaging in recent years led to improved diagnostic accuracy in identifying the specific causes of heart failure and also provided physicians with guidelines for appropriately managing patients with heart failure. Diseases that were once considered rare are now ..
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Cardiology / Review
Optimization of guideline-directed medical treatment for heart failure patients with reduced ejection fraction
Minjung Bak, Jin-Oh Choi
Korean J Intern Med. 2023;38(5):595-606. Published online September 1, 2023
With the increasing number of medications demonstrating mortality benefits in heart failure with reduced ejection fraction (HFrEF), the pharmacological treatment of HFrEF is entering a new phase. To enhance outcomes in heart failure patients through medical treatment, the choice of appropriate medic..
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Geriatrics / Original Article
Predictors of 3-month mortality with muscle ultrasound and palliative prognostic tools among patients admitted to palliative care units
Zeynep Irmak Kaya, Yelda Öztürk, Sinem Gürcü, Gülgün Uncu, Anıl Uçan, Mert Eşme, Berrin Yalınbaş Kaya, Cafer Balci
Korean J Intern Med. 2023;38(4):557-565. Published online March 31, 2023
Background/Aims: Prognostic factors are an important issue in progressive and life-limiting diseases. This study evaluate 3-month mortality in patients admitted to the palliative care unit (PCU).
Methods: In this study, the patient’s demographics, comorbidities, nutritional status, and laboratory..
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Rheumatology / Original Article
Comparative effectiveness of JAK inhibitors and biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
Soo-Kyung Cho, Hyoungyoung Kim, Yeo-Jin Song, Hye Won Kim, Eunwoo Nam, Shin-Seok Lee, Hye-Soon Lee, Sung-Hoon Park, Yeon-Ah Lee, Min-Chan Park, Sung Hae Chang, Hyoun-Ah Kim, Seung-Ki Kwok, Hae-Rim Kim, Hyun-Sook Kim, Bo Young Yoon, Wan-Sik Uhm, Yong-Gil Kim, Jae Hoon Kim, Jisoo Lee, Jeongim Choi, Yoon-Kyoung Sung
Korean J Intern Med. 2023;38(4):546-556. Published online June 20, 2023
Background/Aims: We aimed to compare the effectiveness and safety of Janus kinase inhibitors (JAKi) vs. biologic disease- modifying antirheumatic drugs (bDMARD) in Korean patients with rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic DMARDs.
Methods: A quasi-exper..
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Cardiology / Original Article
Development and validation of equation for cardiorespiratory fitness in patients with heart failure with preserved ejection fraction
Byambakhand Battumur, Ji Eun Lee, Soo Hyung Park, You-Jung Choi, Dong Oh Kang, Eun Jin Park, Ji Bak Kim, Jah Yeon Choi, Seung Young Roh, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Seung Woon Rha, Chang Gyu Park, Eung Ju Kim
Korean J Intern Med. 2023;38(4):514-525. Published online June 20, 2023
Background/Aims: Cardiorespiratory fitness (CRF), as measured by maximal oxygen consumption (VO2max), is an important independent predictive factor of cardiovascular outcomes in patients with heart failure (HF). However, it is unclear whether conventional equations for estimating CRF are applicable ..
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Gastroenterology / Original Article
Efficacy and safety of sofosbuvir–velpatasvir and sofosbuvir–velpatasvir–voxilaprevir for hepatitis C in Korea: a Phase 3b study
Jeong Heo, Yoon Jun Kim, Sung Wook Lee, Youn-Jae Lee, Ki Tae Yoon, Kwan Soo Byun, Yong Jin Jung, Won Young Tak, Sook-Hyang Jeong, Kyung Min Kwon, Vithika Suri, Peiwen Wu, Byoung Kuk Jang, Byung Seok Lee, Ju-Yeon Cho, Jeong Won Jang, Soo Hyun Yang, Seung Woon Paik, Hyung Joon Kim, Jung Hyun Kwon, Neung Hwa Park, Ju Hyun Kim, In Hee Kim, Sang Hoon Ahn, Young-Suk Lim
Korean J Intern Med. 2023;38(4):504-513. Published online June 30, 2023
Background/Aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains for pangenotypic regimens that can be used in the presence of hepatic impairment, comorbidities, or prior treatment failure. We investigated the efficacy an..
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Gastroenterology / Original Article
Ten-day tegoprazan-based concomitant therapy as a first-line treatment for Helicobacter pylori eradication
Yong Hwan Kwon, Seong Woo Jeon, Su Youn Nam, Dong Wook Lee, Ji Hey Park, Hui Jin Bae
Korean J Intern Med. 2023;38(4):493-503. Published online June 28, 2023
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of Helicobacter pylori..
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Cardiology / Review
Advanced heart failure: a contemporary approach
Kyeong-Hyeon Chun, Seok-Min Kang
Korean J Intern Med. 2023;38(4):471-483. Published online June 28, 2023
Advanced heart failure (HF) is defined as the persistence of severe symptoms despite the use of optimized medical, surgical, and device therapies. These patients require timely advanced treatments, such as heart transplantation or long-term mechanical circulatory support (MCS). Inotropic agents are ..
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Cardiology / Review
Role of echocardiography in acute pulmonary embolism
Jin Kyung Oh, Jae-Hyeong Park
Korean J Intern Med. 2023;38(4):456-470. Published online January 2, 2023
Although pulmonary embolism (PE)-related mortality rate has decreased because of prompt diagnosis and effective therapy use, acute PE remains a potentially lethal disease. Due to its increasing prevalence, clinicians should pay attention to diagnosing and managing patients with acute PE. Echocardiog..
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