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Original Article
Selectively Decreased Expression of Peroxiredoxins Induced by Silica in Pulmonary Epithelial Cells
Hye Lim Lee, Young Sun Kim, Joo Hun Park, Wou Young Chung, Kyu Sung Lee, Yoon Jung Oh, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang
Korean J Intern Med. 2009;24(3):220-226. Published online August 26, 2009
Background/AimsPeroxiredoxin (Prx) belongs to a ubiquitous family of antioxidant enzymes that regulates many cellular processes through intracellular oxidative signal transduction pathways. Silica-induced lung damage involves reactive oxygen species (ROS) that trigger subseque..
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Case Report
Gastric Yolk Sac Tumor: A Case Report and Review of the Literature
Yeon Soo Kim, Seok Hyun Kim, Jae Koo Seong, Byung Seok Lee, Hyun Yong Jeong, Kyu Sang Song
Korean J Intern Med. 2009;24(2):143-146. Published online June 8, 2009
Gastric yolk sac tumors are extremely rare and their prognosis is poor; most patients have widespread metastases at the time of diagnosis. The treatment of gastric yolk sac tumors consists of aggressive chemotherapy combined with radiotherapy and surgery. Here, we first report a case of gastric y..
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Original Article
Differences in Insulin Sensitivity and Secretory Capacity Based on OGTT in Subjects with Impaired Glucose Regulation
Sang Youl Rhee, Mi Kwang Kwon, Byong-Jo Park, Suk Chon, In-Kyung Jeong, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Sung Woon Kim, Jin-Woo Kim, Young Seol Kim, Jeong-taek Woo
Korean J Intern Med. 2007;22(4):270-274. Published online December 20, 2007
BackgroundThis study examined whether defects in insulin secretion contribute to the development and progression of type 2 diabetes mellitus (T2DM). MethodsPlasma insulin and glucose were measured after a glucose tolerance tes..
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Original Article
IGF-1 is an Independent Risk Factor for Anemia in Diabetic Pre-dialysis Patients
Do-Hyoung Kim, Tae-Young Kim, Sun-Min Kim, Soo-Jeong Yoo, Dong-Jin Oh, Suk-Hee Yu
Korean J Intern Med. 2007;22(3):186-191. Published online September 30, 2007
BackgroundWe investigated whether the presence of diabetes mellitus (DM) was related to the degree of the anemia in predialytic patients with renal failure and what was the most relevant factor for anemia in patients with chronic kidney disease (CKD) from DM (DM-CKD).
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Case Report
Case of Pseudomembranous Necrotizing Tracheobronchial Aspergillosis in an Immunocompetent Host
Hyo-Jeong Oh, Hak-Ryul Kim, Ki-Eun Hwang, So-Young Kim, Sun-Ho Ahn, Sei-Hoon Yang, Eun-Taik Jeong
Korean J Intern Med. 2006;21(4):279-282. Published online December 31, 2006
A 44-year-old Korean male died of rapidly progressive respiratory failure and refractory hypoxemia in 8 days after being admitted with a fever and dyspnea. The patient was diagnosed with pseudomembranous necrotizing tracheobronchial aspergillosis by fibroptic bronchoscopy and it was not related t..
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Original Article
Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
Jeong-Sup Song, Kyung-Sook Cho, Hyung-Kyu Yoon, Hwa-Sik Moon, Sung-Hak Park
Korean J Intern Med. 2005;20(4):275-283. Published online December 31, 2005
BackgroundNeutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway through which NE induces MUC5AC gene expression in bronchial..
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Case Report
Congenital Double-Orifice Mitral Valve with Mitral Regurgitation due to Flail Leaflet in an Elderly Patient
Shin-Jae Kim, Eun-Seok Shin, Sang-Gon Lee
Korean J Intern Med. 2005;20(3):251-254. Published online September 30, 2005
We report here on a case of double-orifice mitral valve with mitral regurgitation in a 75-year-old female who had complaints of mild dyspnea. Transthoracic and transesophageal echocardiography showed two orifices that were supplied by their own chordae from a different papillary muscle. Color Dop..
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Original Article
High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
Won Hyuk Choe, Sun-Young Lee, Jun Haeng Lee, Sang Goon Shim, Young-Ho Kim, Poong-Lyul Rhee, Jong Chul Rhee, Chang-Seok Ki, Jong-Won Kim, Sang Yong Song, Jae J. Kim
Korean J Intern Med. 2005;20(2):116-122. Published online June 30, 2005
BackgroundAlthough there have been some reports on microsatellite alterations in gastric cancer, findings are inconsistent regarding the associations between histological classification and microsatellite instability (MSI). In the present study, we attempted to determine wheth..
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Original Article
Overweight and Effect of Hormone Replacement Therapy on Lipid Profiles in Postmenopausal Women
Hong Sook Ko, Chee Jeong Kim, Wang Seong Ryu
Korean J Intern Med. 2005;20(1):33-39. Published online March 31, 2005
BackgroundMany experimental and observational studies have suggested that hormone replacement therapy (HRT) in postmenopausal women is cardioprotective. However, the results of randomized controlled trials have been discouraging. We attempted to evaluate the influence of overw..
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