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Nephrology / Original Article
Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Korean J Intern Med. 2018;33(3):568-576. Published online March 18, 2017
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral urete..
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Nephrology / Original Article
Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Korean J Intern Med. 2018;33(3):561-567. Published online March 13, 2017
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF).
Methods: We r..
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Endocrinology-metabolism / Original Article
Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-young Oh
Korean J Intern Med. 2018;33(3):552-560. Published online February 8, 2017
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and ..
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Pulmonology / Original Article
Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Pulmonology / Original Article
Histopathologic heterogeneity of acute respiratory distress syndrome revealed by surgical lung biopsy and its clinical implications
Jimyung Park, Yeon Joo Lee, Jinwoo Lee, Sung Soo Park, Young-Jae Cho, Sang-Min Lee, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2018;33(3):532-540. Published online November 1, 2017
Background/Aims: Diffuse alveolar damage (DAD) is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). However, there are several non-DAD conditions mimicking ARDS. The purpose of this study was to investigate the histopathologic heterogeneity of ARDS revealed by surgical lung..
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Cardiology / Original Article
Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Korean J Intern Med. 2018;33(3):522-531. Published online October 19, 2017
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated.
Methods: Blood sam..
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Cardiology / Original Article
Prognostic value of total triiodothyronine and free thyroxine levels for the heart failure in patients with acute myocardial infarction
Min Gyu Kang, Jong Ryeal Hahm, Kye-Hwan Kim, Hyun-Woong Park, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Choong Hwan Kwak
Korean J Intern Med. 2018;33(3):512-521. Published online January 11, 2017
Background/Aims: Although a low triiodothyronine (T3) state is closely associated with heart failure (HF), it is uncertain whether total T3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value..
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Gastroenterology / Original Article
Effect of Helicobacter pylori eradication on the regression of gastric polyps in National Cancer Screening Program
Su Youn Nam, Bum Joon Park, Kum Hei Ryu, Ji Hyung Nam
Korean J Intern Med. 2018;33(3):506-511. Published online December 14, 2017
Background/Aims: Western guidelines recommend Helicobacter pylori eradication in H. pylori-associated gastric polyps; however, there is no standard guideline in Korea. The aim of this study is to assess the effect of H. pylori eradication on the regression of gastric hyperplasti..
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Gastroenterology / Original Article
Efficacy of preoperative percutaneous cholecystostomy in the management of acute cholecystitis according to severity grades
Seong Yeol Kim, Kyo-Sang Yoo
Korean J Intern Med. 2018;33(3):497-505. Published online January 6, 2017
Background/Aims: The aim of this retrospective study was to assess the efficacy of percutaneous cholecystostomy (PC) for patients with acute cholecystitis (AC) according to severity.
Methods: A total of 325 patients who underwent cholecystectomy between January 2008 and October 2010 were enrolled. ..
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ETC / Review
Fundamental role of dendritic cells in inducing Th2 responses
Byoungjae Kim, Tae Hoon Kim
Korean J Intern Med. 2018;33(3):483-489. Published online March 5, 2018
A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, part..
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Cardiology / Review
Expanding transcatheter aortic valve replacement into uncharted indications
Guson Kang, Juyong Brian Kim
Korean J Intern Med. 2018;33(3):474-482. Published online March 20, 2018
Since the first-in-man transcatheter delivery of an aortic valve prosthesis in 2002, the landscape of aortic stenosis therapeutics has shifted dramatically. While initially restricted to non-surgical cases, progressive advances in transcatheter aortic valve replacement and our understanding of its s..
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Cardiology / Review
How to tackle congestion in acute heart failure
Pieter Martens, Wilfried Mullens
Korean J Intern Med. 2018;33(3):462-473. Published online April 11, 2018
Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual conges..
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Gastroenterology / Review
Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
Kwang Yong Shim, Young Woo Eom, Moon Young Kim, Seong Hee Kang, Soon Koo Baik
Korean J Intern Med. 2018;33(3):453-461. Published online February 21, 2018
The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1–7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector ..
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Image of interest
Splenic infarction associated with acute infectious mononucleosis
Yuji Suzuki, Keisuke Kakisaka, Hidekatsu Kuroda, Tokio Sasaki, Yasuhiro Takikawa
Korean J Intern Med. 2018;33(2):451-452. Published online May 8, 2017
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Image of interest
Sarcoidosis with splenic involvement diagnosed via endoscopic ultrasound-guided fine-needle biopsy
Hyung Ku Chon, Keum Ha Choi, Tae Hyeon Kim
Korean J Intern Med. 2018;33(2):449-450. Published online May 15, 2017
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Letter to the editor
Dasatinib induces severe hemorrhagic colitis in a patient with accelerated phase of chronic myelogenous leukemia
Eunjung Yim, Yeon-Geun Choi, Yoon-Jeong Nam, Jain Lee, Jeong-A Kim
Korean J Intern Med. 2018;33(2):446-448. Published online March 10, 2016
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Letter to the editor
Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib
Sun Young Lee, Na-Ri Lee
Korean J Intern Med. 2018;33(2):442-445. Published online April 15, 2016
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Letter to the editor
Synchronous diffuse large B-cell lymphoma of the small intestine and adenocarcinoma of the colon
Ji Hyun Yang, Jain Lee, Shin Bum Kim, Seon Hoo Kim, Guk Jin Lee
Korean J Intern Med. 2018;33(2):438-441. Published online November 10, 2017
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