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Pulmonology / Original Article
Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2020;35(3):619-629. Published online March 19, 2020
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the exp..
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Cardiology / Original Article
Prevention of medical malpractice and disputes through analysis of lawsuits related to coronary angiography and intervention
Cheol Won Hyeon, Won Lee, So Yoon Kim, Ji Yong Park, Su Hwan Shin
Korean J Intern Med. 2020;35(3):605-618. Published online June 14, 2019
Background/Aims: Possible fatal complications arising from coronary angiography (CAG), percutaneous coronary intervention (PCI), and coronary artery disease itself, are likely to cause medical disputes. Presenting the current status and reasons for judgments given in lawsuits related to CAG/PCI, thi..
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Gastroenterology / Original Article
Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy
Young Woon Chang, Yoo Min Park, Chi Hyuk Oh, Shin Ju Oh, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2020;35(3):574-581. Published online December 12, 2019
Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli s..
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Gastroenterology / Original Article
Clinical correlation between serum pepsinogen level and gastric atrophy in gastric neoplasm
Jae Hwang Cha, Jin Seok Jang
Korean J Intern Med. 2020;35(3):550-558. Published online November 7, 2018
Background/Aims: The relationship between the serum pepsinogen (sPG) level and changes in gastric mucosa has been well studied. Here, we evaluated the usefulness of sPG (I, II, I/II ratio) and intragastric pH as a biomarker of severe gastric atrophy in gastric neoplastic lesions.
Methods: A total of..
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Review
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Korean J Intern Med. 2020;35(3):535-543. Published online April 29, 2020
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid..
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Pulmonology / Original Article
QuantiFERON-TB Gold PLUS versus QuantiFERON- TB Gold In-Tube test for diagnosing tuberculosis infection
Soo Han Kim, Kyung-Wook Jo, Tae Sun Shim
Korean J Intern Med. 2020;35(2):383-391. Published online December 26, 2019
Background/Aims: QuantiFERON-TB Gold PLUS (QFT-PLUS) was developed as a new version of the interferon-γ (IFN-γ) release assay that contains an extra antigen tube to elicit a CD8+ T-cell response in addition to a CD4+ T-cell response. This study aimed to evaluate the performances of QFT-PLUS versus..
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Cardiology / Original Article
Clinical profiles of patients with surgically resected pheochromocytoma and paraganglioma
Sun Hwa Lee, Jae-Hyeong Park, Ja-Yeon Lee, Sang-Rok Lee, Kyoung-Suk Rhee, Jei-Keon Chae, Won-Ho Kim, Ji-Young Sul, Jin Kyung Oh, Hee-Jin Kwon, Jae-Hwan Lee, In-Whan Seong
Korean J Intern Med. 2020;35(2):351-359. Published online February 28, 2019
Background/Aims: Pheochromocytoma and paraganglioma (PPGL) are catecholamine-producing tumors that can cause blood pressure (BP) elevation and cardiovascular complications. Clinical presentation of these tumors may be changed through widespread use of imaging studies, which enables detection of PPG..
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Pulmonology / Review
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Hemato-oncology / Original Article
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance
Hee Kyung Kim, Wonseok Kang, Dong Hyun Sinn, Joon Hyeok Lee, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2020;35(1):194-204. Published online April 4, 2019
Background/Aims: Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL).
Methods: A cross-sectional study analyzed FL patients who were ..
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Gastroenterology / Original Article
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Gastroenterology / Original Article
Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study
Won-Jong Yang, Eunhee Park, Yu-Sun Min, Jae-Won Huh, Ae Ryoung Kim, Hyun-Min Oh, Tae-Woo Nam, Tae-Du Jung
Korean J Intern Med. 2020;35(1):79-87. Published online January 2, 2020
Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs).
Methods: This study was a retrospective review of med..
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Rheumatology / Original Article
Standardized, musculoskeletal ultrasonographic reference values for healthy Korean adults
Hyun-Sook Kim, Hae-Rim Kim, Bo Young Kim, Yun Sung Kim, Young Ok Jung, Sung Jae Choi, Hyun-Ok Kim, Jiwon Hwang, Sunggun Lee, Hyoun-Ah Kim, So Young Bang, Ji-Young Chai, Sung-Hoon Park, Chong-Hyeon Yoon
Korean J Intern Med. 2019;34(6):1372-1380. Published online May 4, 2018
Background/Aims: To define standard reference values for musculoskeletal ultrasonography (MSUS) in Korea.
Methods: A total of 251 healthy adults were recruited for this study. Ultrasonography was performed by experienced rheumatologists who had undergone four appropriate training programs in Korea..
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Infectious diseases / Original Article
Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis
Eun-Jeong Joo, Dong Ah Park, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Sang Moo Lee, Kyong Ran Peck
Korean J Intern Med. 2019;34(6):1347-1362. Published online January 20, 2018
Background/Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation.
Meth..
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Hemato-oncology / Original Article
Modified dose of melphalan-prednisone in multiple myeloma patients receiving bortezomib plus melphalan-prednisone treatment
Se Ryeon Lee, Hojoon Choi, Byung Hyun Lee, Ka-Won Kang, Eun Sang Yu, Dae Sik Kim, Yong Park, Chul Won Choi, Byung Soo Kim, Hwa Jung Sung
Korean J Intern Med. 2019;34(6):1333-1346. Published online October 26, 2018
Background/Aims: Bortezomib plus melphalan-prednisone (VMP) is a standard treatment for multiple myeloma, particularly for patients who are ineligible for high-dose therapy. However, early discontinuation or treatment modification is often needed owing to adverse events. The aim of this study was to..
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Endocrinology-metabolism / Original Article
Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Korean J Intern Med. 2019;34(6):1287-1296. Published online March 13, 2018
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.
Methods: We retrospectively review..
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Gastroenterology / Original Article
Liver volume index predicts the risk of esophageal variceal hemorrhage in cirrhotic patients on propranolol prophylaxis
Beom Hee Kim, Jung Wha Chung, Chung Seop Lee, Eun Sun Jang, Sook-Hyang Jeong, Nayoung Kim, Jin-Wook Kim
Korean J Intern Med. 2019;34(6):1233-1243. Published online February 18, 2019
Background/Aims: Non-selective β-blockers (NSBBs) are used for primary prevention of esophageal variceal hemorrhage (VH) in patients with portal hypertension, but a significant number of patients develop VH while on NSBB therapy. In this study, we sought to determine whether liver volume can predi..
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Hemato-oncology / Original Article
Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer
Chan-Young Ock, Shin-Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2019;34(5):1116-1124. Published online June 29, 2018
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factor..
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Nephrology / Original Article
Clinical outcomes and effects of treatment in older patients with idiopathic membranous nephropathy
Yaeni Kim, Hye Eun Yoon, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Yu Ah Hong, Suk Young Kim, Yoon-Kyung Chang, Hyeon Seok Hwang
Korean J Intern Med. 2019;34(5):1091-1099. Published online August 14, 2019
Background/Aims: Membranous nephropathy (MN) is the most common primary glomerular disease diagnosed in older patients. Few reports describe the clinical outcomes in older patients with idiopathic MN.
Methods: The outcomes of 135 patients with histologically proven MN were analyzed. ‘Older’ was ..
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Pulmonology / Original Article
Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment
Tae-Ok Kim, Hong-Joon Shin, Yu-Il Kim, Sung-Chul Lim, Young-Il Koh, Yong-Soo Kwon
Korean J Intern Med. 2019;34(5):1050-1057. Published online March 19, 2019
Background/Aims: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients undergoing anti-TB treatment.
Methods: We retrospecti..
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Hemato-oncology / Original Article
Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance
Koung Jin Suh, Ki Hwan Kim, Ryul Kim, Ja Min Byun, Miso Kim, Jin Hyun Park, Bhumsuk Keam, Tae Min Kim, Jin-Soo Kim, In Sil Choi, Dae Seog Heo
Korean J Intern Med. 2019;34(4):894-901. Published online February 23, 2018
Background/Aims: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear.
Methods: Medical costs within the first 3 years of treatment completion and clinical outcomes of 118..
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