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Hemato-oncology / Review
Chronic lymphocytic leukemia: a clinical review including Korean cohorts
Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2016;31(3):433-443. Published online April 5, 2016
Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterizati..
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Allergy / Review
What we know about nonsteroidal anti-inflammatory drug hypersensitivity
Duy Le Pham, Ji-Hye Kim, Tu Hoang Kim Trinh, Hae-Sim Park
Korean J Intern Med. 2016;31(3):417-432. Published online March 31, 2016
Nonsteroidal anti-inf lammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammatory diseases, but their use is frequently related to hypersensitivity reactions. This review outlines our current knowledge of NSAID hypersensitivity (NHS) with regard to its pathogenic, molecular, and..
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Letter to the editor
Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer
Jae Heun Chung, Min Wook So, Seong-Geun Kim
Korean J Intern Med. 2016;31(2):413-416. Published online January 29, 2016
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Image of interest
Fluorodeoxyglucose-positron emission tomography/computed tomography imaging of squamous cell carcinoma arising in a meningomyelocele
Seval Erhamamcı, Mehmet Reyhan, Nebil Bal
Korean J Intern Med. 2016;31(2):411-412. Published online December 23, 2015
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Image of interest
Widespread intracranial calcifications in a patient with hypoparathyroidism
Jeong Young Seo, Ju Hyun Seo, Younghee Choe, Hannah Seok, Tae-Seo Sohn
Korean J Intern Med. 2016;31(2):409-410. Published online January 29, 2016
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Letter to the editor
Mixed-phenotype acute leukemia treated with decitabine
Ji-Young Lee, Sang-min Lee, Ja-Young Lee, Ki-Hyang Kim, Moon-Young Choi, Won-Sik Lee
Korean J Intern Med. 2016;31(2):406-408. Published online February 15, 2016
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Letter to the editor
Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis
A Young Cho, Byeong Gwan Kim, Sang Sun Kim, Seong Hee Lee, Hong Shik Shin, Yeong Jin Choi, In O Sun
Korean J Intern Med. 2016;31(2):403-405. Published online February 11, 2016
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Letter to the editor
Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy
Ihn Suk Lee, Jung Uee Lee, Kwan-Ju Lee, Yi Sun Jang, Jong Min Lee, Hye Soo Kim
Korean J Intern Med. 2016;31(2):399-402. Published online February 26, 2016
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Letter to the editor
Series with complete resolution of left atrial appendage thrombi with apixaban in elderly patients
Sang Hoon Lee, Seongwook Han
Korean J Intern Med. 2016;31(2):396-398. Published online February 12, 2016
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Letter to the editor
Large Brunner’s gland hamartoma with annular stricture causing gastric outlet obstruction
In Tae Hwang, Young Bum Cho, Dong Eun Park, Keum Ha Choi, Tae Hyeon Kim
Korean J Intern Med. 2016;31(2):392-395. Published online January 25, 2016
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Rheumatology / Original Article
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Adem Kucuk, Mehmet Fatih Erol, Soner Senel, Emir Eroler, Havvanur Alparslan Yumun, Ali Ugur Uslu, Asiye Mukaddes Erol, Deniz Tihan, Ugur Duman, Tevfik Kucukkartallar, Yalcin Solak
Korean J Intern Med. 2016;31(2):386-391. Published online February 11, 2016
Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lym..
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Allergy / Original Article
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Infectious diseases / Original Article
Controlling endemic multidrug-resistant Acinetobacter baumannii in Intensive Care Units using antimicrobial stewardship and infection control
Shinhye Cheon, Mi-Ja Kim, Seon-Jin Yun, Jae Young Moon, Yeon-Sook Kim
Korean J Intern Med. 2016;31(2):367-374. Published online February 15, 2016
Background/Aims: Nosocomial infections caused by multidrug-resistant (MDR) Acinetobacter baumannii have become public-health problem. However, few studies have evaluated the control of endemic MDR A. baumannii in Intensive Care Units (ICUs). Therefore, we investigated the effectiveness..
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Hemato-oncology / Original Article
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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Nephrology / Original Article
Validation of the Korean coefficient for the modification of diet in renal disease study equation
Yun Jung Oh, Ran-hui Cha, Seung Hwan Lee, Kyung Sang Yu, Satbyul Estella Kim, Ho Kim, Yon Su Kim
Korean J Intern Med. 2016;31(2):344-356. Published online January 13, 2016
Background/Aims: Race and ethnicity are important determinants when estimating
glomerular filtration rate (GFR). The Korean coefficients for the isotope dilution mass spectrometry (IDMS) Modification of Diet in Renal Disease (MDRD) Study equations were developed in 2010. However, the coefficients h..
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Nephrology / Original Article
Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Young-Il Jo, Ha-Young Na, Ju-Young Moon, Sang-Woong Han, Dong-Ho Yang, Sang-Ho Lee, Hyeong-Cheon Park, Hoon-Young Choi, So-Dug Lim, Jeong-Hae Kie, Yong-Kyu Lee, Sug-Kyun Shin
Korean J Intern Med. 2016;31(2):335-343. Published online February 15, 2016
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normo..
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Nephrology / Original Article
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal
injury in unilateral ureteral obstructed mice
Sarah Chung, Jin Young Jeong, Yoon Kyung Chang, Dae Eun Choi, Ki Ryang Na, Beom Jin Lim, Kang Wook Lee
Korean J Intern Med. 2016;31(2):323-334. Published online February 26, 2016
Background/Aims: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression in mice, the exact relationship between TLR2 and RAS is not known. The aim of th..
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Endocrinology-metabolism / Original Article
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2016;31(2):313-322. Published online December 23, 2015
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer.
Methods: All 2D data were interpreted in real time and 3D data were sto..
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Pulmonology / Original Article
Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
So Young Park, Sang Min Lee, Jong Wook Shin, Byoung Whui Choi, Hojoong Kim, Jae Seung Lee, Sang Do Lee, Sung Soo Park, Hwa Sik Moon, Yong Bum Park
Korean J Intern Med. 2016;31(2):305-312. Published online January 29, 2016
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o..
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Pulmonology / Original Article
Facility characteristics as independent prognostic factors of nursing home-acquired pneumonia
Che Wan Lim, Younghoon Choi, Chang Hyeok An, Sang Joon Park, Hee-Jin Hwang, Jae Ho Chung, Joo-Won Min
Korean J Intern Med. 2016;31(2):296-304. Published online February 2, 2016
Background/Aims: Recently, the incidence of nursing home-acquired pneumonia (NHAP) has been increasing and is now the leading cause of death among nursing home residents. This study was performed to identify risk factors associated with NHAP mortality, focusing on facility characteristics.
Methods:..
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