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Hemato-oncology / Original Article
Comparison of the morphologic criteria (RECIST) and metabolic criteria (EORTC and PERCIST) in tumor response assessments: a pooled analysis
Hong Deok Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
Korean J Intern Med. 2019;34(3):608-617. Published online January 17, 2018
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morpho..
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Nephrology / Original Article
Intradialytic exercise improves physical function and reduces intradialytic hypotension and depression in hemodialysis patients
So Yon Rhee, Jin Kyung Song, Suk Chul Hong, Jae Won Choi, Hee Jung Jeon, Dong Ho Shin, Eun Hee Ji, Eun-Hee Choi, Jiyeon Lee, Aram Kim, Seung Wook Choi, Jieun Oh
Korean J Intern Med. 2019;34(3):588-598. Published online August 25, 2017
Background/Aims: As numbers of maintenance hemodialysis patients are growing, debilitating conditions of muscle wasting and atrophy are becoming some of the greatest concerns in end-stage renal disease patients. Exercise training has various potential benefits in terms of prevention of a sustained d..
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Gastroenterology / Original Article
Time-dependent reversal of significant intrapulmonary shunt after liver transplantation
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Korean J Intern Med. 2019;34(3):510-518. Published online March 5, 2018
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited.
Methods: Hand-agitated saline was used for CE a..
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Cardiology / Review
Adiponectin for the treatment of diabetic nephropathy
Jun Young Lee, Jae Won Yang, Byoung Geun Han, Seung Ok Choi, Jae Seok Kim
Korean J Intern Med. 2019;34(3):480-491. Published online April 30, 2019
The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to substantial structural changes such as formation of advanced glycation end-products, glo..
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Infectious diseases / Original Article
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Korean J Intern Med. 2019;34(2):409-417. Published online October 12, 2017
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients ..
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Nephrology / Original Article
Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy
Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2019;34(2):375-382. Published online December 15, 2017
Background/Aims: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV infection after ATG administration as anti-rejection therapy.
Methods..
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Pulmonology / Original Article
Evaluation of high resolution computed tomography findings of cystic fibrosis
Ayse Senay Sasihuseyinoglu, Derya Ufuk Altıntaş, Sureyya Soyupak, Dilek Dogruel, Mustafa Yılmaz, Mahir Serbes, Gulsah Duyuler
Korean J Intern Med. 2019;34(2):335-343. Published online July 6, 2018
Background/Aims: Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators...
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Gastroenterology / Review
Endoscopic management of anastomotic stricture after living-donor liver transplantation
Dong Wook Lee, Jimin Han
Korean J Intern Med. 2019;34(2):261-268. Published online February 25, 2019
The most effective and fundamental treatment for end-stage liver disease is liver transplantation. Deceased-donor liver transplantation has been performed for many of these cases. However, living-donor liver transplantation (LDLT) has emerged as an alternative because it enables timely procurement o..
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Rheumatology / Original Article
Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):220-226. Published online October 19, 2017
Background/Aims: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor.
Methods: We retrospectively reviewed the medical records..
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Infectious diseases / Original Article
Clinical and microbiological factors associated with early patient mortality from methicillin-resistant Staphylococcus aureus bacteremia
Tark Kim, Yong Pil Chong, Ki-Ho Park, Kyung Mi Bang, Su-Jin Park, Sung-Han Kim, Jin-Yong Jeong, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
Korean J Intern Med. 2019;34(1):184-194. Published online July 6, 2017
Background/Aims: Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) is a major bloodstream infection with a high mortality rate. Identification of factors associated with early mortality in MRSAB patients would be useful for predicting prognosis and developing new therapeutic opti..
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Nephrology / Original Article
Value of Doppler evaluation of physically abnormal fistula: hemodynamic guidelines and access outcomes
Seong Cho, Yu-Ji Lee, Sung-Rok Kim
Korean J Intern Med. 2019;34(1):137-145. Published online April 18, 2017
Background/Aims: The strategy of access care at out center involves the use of ultrasound (USG) in case of physical examination (PE) abnormality. USG determines the need of angiography. This study investigated the possible association between the need for percutaneous transluminal angioplasty (PTA) ..
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Rheumatology / Original Article
Systemic review: agreement between the latent tuberculosis screening tests among patients with rheumatic diseases
Junhee Pyo, Soo-Kyung Cho, Dam Kim, Yoon-Kyoung Sung
Korean J Intern Med. 2018;33(6):1241-1251. Published online December 28, 2017
Background/Aims: To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying rheumatic diseases and endemic tuberculosis levels.
Methods: The Ovid-Medline, Embase, and Coch..
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Hemato-oncology / Original Article
The effect of the dexamethasone, cytarabine, and cisplatin (DHAP) regimen on stem cell mobilization and transplant outcomes of patients with non-Hodgkin’s lymphoma who are candidates for up-front autologous stem cell transplantation
So Yeon Jeon, Ho-Young Yhim, Hee Sun Kim, Jeong-A Kim, Deok-Hwan Yang, Jae-Yong Kwak
Korean J Intern Med. 2018;33(6):1169-1181. Published online January 8, 2018
Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin’s lymphoma (NHL) is limited.
Methods: Consecutive patients with aggressive NHL ..
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Pulmonology / Original Article
Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication
Jie Gao, Shunyi Feng, Yong Li
Korean J Intern Med. 2018;33(6):1137-1142. Published online May 31, 2018
Background/Aims: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats.
Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly di..
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Gastroenterology / Original Article
Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group
Jin Woo Park, Ja Sung Choi, Ki Joon Han, Sang Heun Lee, Eui Joo Kim, Jae Hee Cho
Korean J Intern Med. 2018;33(6):1103-1110. Published online November 10, 2017
Background/Aims: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytoki..
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Allergy / Original Article
Management and educational status of adult anaphylaxis patients at emergency department
Mi-Yeong Kim, Chan Sun Park, Jae-won Jeong
Korean J Intern Med. 2018;33(5):1008-1015. Published online December 28, 2017
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs).
Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, managemen..
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Hemato-oncology / Original Article
The neutrophil-to-lymphocyte ratio prechemotherapy and postchemotherapy as a prognostic marker in metastatic gastric cancer
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Korean J Intern Med. 2018;33(5):990-999. Published online May 4, 2018
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC).
M..
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Hemato-oncology / Original Article
Third-party regulatory T cells prevent murine acute graft-versus-host disease
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2018;33(5):980-989. Published online October 19, 2017
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used ..
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Nephrology / Original Article
Predialysis hyponatremia and mortality in elderly patients beginning to undergo hemodialysis
Seon Ha Baek, Sejoong Kim, Ki Young Na, Suhnggwon Kim, Ho Jun Chin
Korean J Intern Med. 2018;33(5):970-979. Published online October 19, 2017
Background/Aims: Predialysis hyponatremia has been recently reported to be associated with mortality in incident hemodialysis patients. However, whether hyponatremia is associated with unfavorable outcomes in elderly patients remains unknown. We hypothesized that nephrology referral inf luences hypo..
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Allergy / Review
Genetic markers of severe cutaneous adverse reactions
Jae-Woo Jung, Jae-Yeol Kim, In-Won Park, Byoung-Whui Choi, Hye-Ryun Kang
Korean J Intern Med. 2018;33(5):867-875. Published online June 22, 2018
Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they c..
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