| Editorials |
|
Pulmonology / Editorial
Rethinking adjunctive dobutamine in septic shock: time to individualize, not generalize
Su Hwan Lee
Korean J Intern Med. 2025;40(6):861-862. Published online October 31, 2025
|
|
|
|
| Reviews |
|
Cardiology / Review
Coagulopathy and platelet abnormalities in patients with inflammatory bowel disease
Dae Sung Kim, Won Moon
Korean J Intern Med. 2025;40(6):866-875. Published online October 31, 2025
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is associated with a hypercoagulable state that increases thromboembolic complication risk. The interaction between inflammation and coagulation increases risk by upregulating coagulation factors, downregulating natu..
|
|
|
Pulmonology / Review
Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations
Ji Yoon Kim, Suk Min Chung, Nam Hoon Kim
Korean J Intern Med. 2025;40(6):876-889. Published online October 31, 2025
Patients with chronic kidney disease (CKD) have a significantly increased risk of developing cardiovascular disease (CVD), making dyslipidemia management a critical component of cardiovascular risk reduction in this population. However, as the estimated glomerular filtration rate declines, distinct p..
|
|
|
Pulmonology / Review
Shared decision-making for kidney replacement therapy: a comprehensive review and a proposed model
Hyun Jung Shin, Seoyoung Choi, Sejoong Kim
Korean J Intern Med. 2025;40(6):890-908. Published online October 31, 2025
Shared decision-making (SDM) enables patients to actively engage in healthcare decisions by ensuring that treatment options align with their values and preferences. The use of SDM is increasingly recognized in the context of selecting kidney replacement therapy (KRT) for patients with chronic kidney..
|
|
|
Pulmonology / Review
Clinical challenges and individualized approaches to dialysis therapy in older adults
Sungmi Kim, Yu Ah Hong
Korean J Intern Med. 2025;40(6):909-926. Published online October 31, 2025
Global population aging has substantially increased in the number of older adults who undergo kidney replacement therapy (KRT). Age-related physiological changes and functional dependence in this population lead to the multifaceted clinical and ethical challenges associated with KRT. Geriatric syndr..
|
|
|
Infectious diseases / Review
Current perspectives on sarcopenia: diagnosis and therapeutic approaches
Jung-Yeon Choi, Kwang-il Kim, Cheol-Ho Choi
Korean J Intern Med. 2025;40(6):927-938. Published online October 31, 2025
Korea is experiencing rapid population aging and entered a super-aged society in December 2024. This demographic shift underscores the growing prevalence of sarcopenia, a progressive skeletal muscle disorder related to aging, characterized by reduced muscle mass, strength, and function, which signif..
|
|
| Original Articles |
|
Gastroenterology / Original Article
Exosomal miRNA-720 as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma
Ji Min Kim, Hye Seon Kim, Jin Seoub Kim, Ji Won Han, Soon Kyu Lee, Heechul Nam, Pil Soo Sung, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang
Korean J Intern Med. 2025;40(6):939-951. Published online October 31, 2025
Background/Aims: Circulating exosomal microRNAs (miRNAs) can serve as diagnostic and prognostic biomarkers for cancer. This study aimed to identify specific miRNAs in serum exosomes of patients with hepatocellular carcinoma (HCC) and validate their biological functions as novel diagnostic and predic..
|
|
|
Gastroenterology / Original Article
Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis
Yongchel Ahn, Hoon Yu, Yoonjong Bae, Mina Kim, Seung Bum Lee
Korean J Intern Med. 2025;40(6):952-960. Published online October 28, 2025
Background/Aims: Assessing the risk of colorectal cancer (CRC) after kidney transplantation (KT) in patients with endstage renal disease (ESRD) receiving dialysis is crucial to determine KT’s risks and benefits. In Korea, the study results remain unclear. Therefore, using a nationwide health scree..
|
|
|
Cardiology / Original Article
Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages
Byung Sik Kim, Hyun-Jin Kim, Shinje Moon, Hasung Kim, Jungkuk Lee, Jeong-Hun Shin
Korean J Intern Med. 2025;40(6):961-974. Published online October 31, 2025
Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome reflects the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Insulin resistance (IR) is a key driver of CKM and is associated with adverse cardiovascular outcomes. The triglyceride-glucose (T..
|
|
|
Cardiology / Original Article
Long-term clinical outcome and risk stratification across stages of cardiovascular-kidney-metabolic syndrome in a nationwide cohort
Hyun-Jin Kim, Byung Sik Kim, Hasung Kim, Jungkuk Lee, Ha Hye Jo, Dong Wook Kim, Jeong-Hun Shin, Ki-Chul Sung
Korean J Intern Med. 2025;40(6):975-989. Published online October 28, 2025
Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome is a continuum of metabolic, cardiovascular, and kidney dysfunctions. This study aimed to evaluate the association between CKM stages and the risk of adverse composite clinical outcomes.
Methods: This retrospective cohort study used da..
|
|
|
Pulmonology / Original Article
Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis
Sung Yoon Lim, Kyu Jin Lee, Yeonhoon Jang, Yeon Joo Lee, Ryoung-Eun Ko, Gee Young Suh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim, Sunghoon Park; on behalf of the Korean Sepsis Alliance (KSA) investigators
Korean J Intern Med. 2025;40(6):990-1001. Published online October 31, 2025
Background/Aims: Despite some evidence supporting its utility, the role of adjunctive dobutamine in the management of septic shock remains unclear.
Methods: The nationwide prospective sepsis cohort of the Korean Sepsis Alliance was analyzed. Adult patients with septic shock receiving norepinephrine..
|
|
|
Pulmonology / Original Article
Predictive value of the modified ROX index for extubation failure in mechanically ventilated patients
Kwonhyung Hyung, Kyung-Eui Lee, Yoon Hae Ahn, Jinwoo Lee, Sang-Min Lee, Hong Yeul Lee
Korean J Intern Med. 2025;40(6):1002-1016. Published online October 31, 2025
Background/Aims: Clinicians use several measures to determine whether patients will tolerate liberation from mechanical ventilation. This study aimed to evaluate the predictive value of the modified ROX index (mROX) for extubation failure. In addition, we sought to find its role in guiding personali..
|
|
|
Endocrinology-metabolism / Original Article
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends
Jeongmin Lee, Kwang Joon Kim, Yang Sun Park, Yong-ho Lee, Kyeong Hye Park, Hee-Won Jung, Bong-Soo Cha, Hun-Sung Kim, Chang Oh Kim
Korean J Intern Med. 2025;40(6):1017-1028. Published online October 31, 2025
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.
Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey..
|
|
|
Hemato-oncology / Original Article
Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer
Young Saing Kim, Eun Young Lee, Hyun Woo Lee, Jin-Hyuk Choi, Tae-Hwan Kim, Yong Won Choi, Mi Sun Ahn
Korean J Intern Med. 2025;40(6):1029-1041. Published online October 31, 2025
Background/Aims: This study aimed to assess the real-world treatment outcomes in South Korean patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) receiving first-line (1L) EGFR tyrosine kinase inhibitors (TKIs).
Methods: We used the Health Insurance Revie..
|
|
|
Rheumatology / Original Article
Treatment satisfaction and its determinants in Korean patients with rheumatoid arthritis and systemic lupus erythematosus
Hyo Jin Choi, Mi Ryoung Seo, Eunji Kim, Han Joo Baek
Korean J Intern Med. 2025;40(6):1042-1051. Published online October 28, 2025
Background/Aims: This study aimed to evaluate the treatment satisfaction and its determinants in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Methods: This cross-sectional study was conducted between September 2021 and December 2021. Data on demographics, clinical..
|
|
|
Rheumatology / Original Article
Real-world clinical response and efficacy of tacrolimus-based maintenance therapy for Korean patients with lupus nephritis
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh
Korean J Intern Med. 2025;40(6):1052-1064. Published online October 28, 2025
Background/Aims: We evaluated the efficacy and safety of tacrolimus as maintenance therapy in Korean patients with lupus nephritis (LN).
Methods: A total of 179 patients with biopsy-proven LN were included, of whom 92 received tacrolimus and 87 did not. Clinical parameters were assessed at six mont..
|
|
| Images of interest |
|
Cardiology / Image of interest
Left main coronary artery compression associated with unfavorable thoracic anatomy
Daeung Ohn, Yeon-Jik Choi, Jin-Young Yoo, Suk-Min Seo, Junghoon Lee
Korean J Intern Med. 2025;40(6):1065-1067. Published online October 31, 2025
|
|
|
Infectious diseases / Image of interest
Disseminated tuberculosis without pulmonary involvement mimicking multiple bone metastases
Hyo-Jin Lee, Seo-Jun Byun, Si-Hyun Kim
Korean J Intern Med. 2025;40(6):1068-1069. Published online October 31, 2025
|
|
|
> Current Issue
Editorial
