A tetraplegic 59-year-old man with invasive home mechanical ventilation administered via tracheostomy was admitted to the intensive care unit due to general discomfort, dyspnea, and low oxygen saturation despite high-flow oxygen therapy. In the chest X-ray, considerable left sided pleural effusion with mediastinal shift towards the right side was detected (Fig. 1). Laboratory findings revealed leukocytosis (15.53 × 10⁹/L) and elevated C-reactive protein (131 mg/L). Computed tomography of the chest confirmed a massive left-sided pleural effusion with pleural enhancement of the contrast agent and subsequent atelectasis of the entire lung parenchyma. Additionally, split pleura sign could be detected corresponding to pleural empyema (Fig. 2, white arrows). Moreover, Escherichia coli and Streptococcus intermedius could be detected from bronchoalveolar lavage fluid. Surgical irrigation and meticulous decortication of the pleural cavity through a left sided posterolateral thoracotomy was performed. Intraoperatively, pleural empyema presented as a green-yellow colored fetid and sticky fluid coating the entire lung surface. Several layers of pus and fibrin were grossly adherent to the parenchyma, mediastinum, and diaphragm. The postoperative course was uneventful, the patient recovered without any sequelae.