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Pulmonology
Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2020;35(3):619-629. Published online March 19, 2020
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the exp..
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Hemato-oncology
Prognostic implications of stromal hyaluronic acid protein expression in resected oropharyngeal and oral cavity cancers
Der Sheng Sun, Hye Sung Won, Soon Auck Hong, Ji Hyung Hong, Heejoon Jo, Heejin Lee, Okran Kim, Myung Ah Lee, Yoon Ho Ko
Korean J Intern Med. 2020;35(2):408-420. Published online July 29, 2019
Background/Aims: Hyaluronic acid (HA) regulates cell adhesion, migration and proliferation in various cancers. The clinical implications of HA in resected head and neck squamous cell carcinoma have not been elucidated. We investigated the clinical significance and prognostic value of the expression ..
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Two different KIT mutations may lead to different responses to imatinib in metastatic gastrointestinal stromal tumor
Eunjung Yim, Ho Jung An, Uiju Cho, Youngwoo Kim, Seung Hoon Kim, Yeon-Geun Choi, Byoung Yong Shim
Korean J Intern Med. 2018;33(2):432-434. Published online July 7, 2016
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Gastroenterology
Endoscopic submucosal dissection of gastric subepithelial tumors: a systematic review and
meta-analysis
Chang Seok Bang, Gwang Ho Baik, In Soo Shin, Ki Tae Suk, Jai Hoon Yoon, Dong Joon Kim
Korean J Intern Med. 2016;31(5):860-871. Published online February 22, 2016
Background/Aims: To evaluate the therapeutic outcomes of the endoscopic submucosal dissection (ESD) technique for the treatment of gastric subepithelial tumors (SETs).
Methods: A systematic literature review was conducted using the core databases. Data on the complete resection rates and the proced..
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Mesenchymal stem cell therapy for liver fibrosis
Young Woo Eom, Kwang Yong Shim, Soon Koo Baik
Korean J Intern Med. 2015;30(5):580-589. Published online August 27, 2015
Currently, the most effective treatment for end-stage liver fibrosis is liver transplantation; however, transplantation is limited by a shortage of donor organs, surgical complications, immunological rejection, and high medical costs. Recently, mesenchymal stem cell (MSC) therapy has been suggested ..
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Hemato-oncology
Clinical applications of mesenchymal stem cells
Nayoun Kim, Seok-Goo Cho
Korean J Intern Med. 2013;28(4):387-402. Published online July 1, 2013
Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppress..
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Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic
Jae Youn Cho
Korean J Intern Med. 2011;26(4):367-383. Published online November 28, 2011
Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in asthma, including transforming growth factor-β, interleukin (IL)-5, basic fib..
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Malignant Gastrointestinal Stromal Tumor in a Patient with Neurofibromatosis type 1
Sang Hoon Han, Se Hoon Park, Gwon Hyun Cho, Na Rae Kim, Jae Hwan Oh, Eunmi Nam, Dong Bok Shin
Korean J Intern Med. 2007;22(1):21-23. Published online March 31, 2007
Neurofibromatosis type 1 (von Recklinghausen's disease, NF-1) is an autosomal-dominant neurocutaneous disorder characterized by abnormal skin pigmentation (café au lait spots and axillary freckling), cutaneous and plexiform neurofibromas, skeletal dysplasias, and Lisch nodules (pigmented iris h..
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