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Nephrology / Original Article
Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Nephrology / Original Article
Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
Sun Chul Kim, Yoon Sook Ko, Hee Young Lee, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho
Korean J Intern Med. 2017;32(6):1053-1061. Published online February 15, 2017
Background/Aims: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of reverse TEM. In this study, we tested the effects of a JAM-C blocki..
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Nephrology / Original Article
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection
Sun Chul Kim, Min Young Seo, Jun Yong Lee, Ki Tae Kim, Eunjung Cho, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho, Hyoung-Kyu Kim
Korean J Intern Med. 2016;31(1):125-133. Published online December 28, 2015
Background/Aims: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C. difficile. However, recent studies of the clinical impact of CKD on CDI in Asia..
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Nephrology / Original Article
Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury
Min Young Seo, Jihyun Yang, Jun Yong Lee, Kitae Kim, Sun Chul Kim, Hyojeong Chang, Nam Hee Won, Myung-Gyu Kim, Sang-Kyung Jo, Wonyong Cho, Hyoung Kyu Kim
Korean J Intern Med. 2015;30(4):489-495. Published online June 29, 2015
Background/Aims: The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated in animal models. However, to date, there have been no human studies investigating the expression of renal Klotho in AKI.
Methods: We retrospectively collected biopsy specimens a..
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