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Endocrinology-metabolism / Original Article
Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study
Dojoon Park, Kyuho Kim, Hae-Seok Koh, Kyungdo Han, Youn-Ho Choi
Korean J Intern Med. 2026;41(3):485-500. Published online May 1, 2026
Background/Aims: Knee osteoarthritis (OA), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) share overlapping mechanisms but are often managed independently. We evaluated whether knee OA increases CVD risk in Korean T2DM patients and whether physical activity (PA) modifies this risk..
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Endocrinology-metabolism / Original Article
Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes
Min-Ji Kim, Sung-Woo Kim, Bitna Ha, Hyang Sook Kim, So-Hee Kwon, Jonghwa Jin, Yeon-Kyung Choi, Keun-Gyu Park, Jung Guk Kim, In-Kyu Lee, Jae-Han Jeon
Korean J Intern Med. 2025;40(2):299-309. Published online March 1, 2025
Background/Aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and B..
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Endocrinology-metabolism / Review
Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
Jae-Seung Yun, Seung-Hyun Ko
Korean J Intern Med. 2015;30(1):6-16. Published online December 30, 2014
Hypoglycemia is a major barrier to achieving the glycemic goal in patients with type 2 diabetes. In particular, severe hypoglycemia, which is defined as an event that requires the assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions, is a seri..
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Review
Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes
Kangduk Choi, Young-Bum Kim
Korean J Intern Med. 2010;25(2):119-129. Published online June 1, 2010
Insulin resistance is a major risk factor for developing type 2 diabetes caused by the inability of insulin-target tissues to respond properly to insulin, and contributes to the morbidity of obesity. Insulin action involves a series of signaling cascades initiated by insulin binding to its recept..
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Original Article
Hepatocyte nuclear factor 1-alpha mutation in normal glucose-tolerant subjects and early-onset type 2 diabetic patients
Dong Mee Lim, Nam Huh, Keun Yong Park
Korean J Intern Med. 2008;23(4):165-169. Published online December 29, 2008
Background/AimsThe prevalence of diabetes in Korea is reported to be approximately 10%, but cases of maturity-onset diabetes of the young (MODY) are rare in Korea. A diagnostic technique for autosomal dominant MODY is being actively sought. In this regard, we used a DNA chip t..
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Original Article
Flexible Initial Dosing of Atorvastatin Based Upon Initial Low-Density Lipoprotein Cholesterol Levels in Type 2 Diabetic Patients
Korean J Intern Med. 2008;23(1):22-29. Published online March 20, 2008
Background/AimsWe used flexible starting doses and early titration of atorvastatin to determine the rate of achievement of a low-density lipoprotein cholesterol (LDL-C) target for hyperlipidemic patients with type 2 diabetes mellitus. Me..
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