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Infectious diseases / Original Article
Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(2):321-329. Published online February 21, 2025
Background/Aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pe..
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Cardiology / Original Article
Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram
Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee
Korean J Intern Med. 2025;40(2):251-261. Published online February 21, 2025
Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..
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Nephrology / Review
Machine learning approaches toward an understanding of acute kidney injury: current trends and future directions
Inyong Jeong, Nam-Jun Cho, Se-Jin Ahn, Hwamin Lee, Hyo-Wook Gil
Korean J Intern Med. 2024;39(6):882-897. Published online October 29, 2024
Acute kidney injury (AKI) is a significant health challenge associated with adverse patient outcomes and substantial economic burdens. Many authors have sought to prevent and predict AKI. Here, we comprehensively review recent advances in the use of artificial intelligence (AI) to predict AKI, and t..
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Allergy / Original Article
Association between specific IgE to staphylococcal enterotoxin B and the eosinophilic phenotype of asthma
Soyoon Sim, Youngwoo Choi, Eun-Mi Yang, Hae-Sim Park
Korean J Intern Med. 2024;39(4):659-667. Published online July 1, 2024
Background/Aims: Sensitization to staphylococcal superantigens (SAgs) could contribute to asthma severity. However, its relevance with eosinophilic phenotype has not yet been clarified. This study aimed to investigate associations between serum specific IgE levels to SAg and eosinophilic airway infl..
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Gastroenterology / Review
Artificial intelligence in colonoscopy: from detection to diagnosis
Eun Sun Kim, Kwang-Sig Lee
Korean J Intern Med. 2024;39(4):555-562. Published online May 2, 2024
This study reviews the recent progress of artificial intelligence for colonoscopy from detection to diagnosis. The source of data was 27 original studies in PubMed. The search terms were “colonoscopy” (title) and “deep learning” (abstract). The eligibility criteria were: (1) the dependent varia..
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Pulmonology / Original Article
Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion
Jaehee Lee, Deok Heon Lee, Ji Eun Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung-Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2024;39(2):318-326. Published online February 14, 2024
Background/Aims: Epidermal growth factor receptor (EGFR) mutation is important in determining the treatment strategy for advanced lung cancer patients with malignant pleural effusion (MPE). Contrary to serum carcinoembryonic antigen (S-CEA) levels, the associations between pleural fluid CEA (PF-CEA)..
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Pulmonology / Original Article
Laboratory and radiological discrimination between tuberculous and malignant pleural effusions with high adenosine deaminase levels
Jaehee Lee, Ji Eun Park, Sun Ha Choi, Hyewon Seo, Sang Yub Lee, Jae Kwang Lim, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2022;37(1):137-145. Published online July 15, 2021
Background/Aims: Pleural fluid adenosine deaminase (ADA) levels are useful in discriminating tuberculous pleural effusions (TPEs) from malignant pleural effusions (MPEs). However, some patients with MPE exhibit high-ADA levels, which may mimic TPEs. There is limited data regarding the differential d..
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Hemato-oncology / Original Article
Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
Chang Hyun Nam, Jaemoon Koh, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2021;36(4):975-984. Published online April 6, 2021
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Methods: This study included patients with non-small cell..
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Pulmonology / Original Article
Performance of pneumococcal urinary antigen test in patients with community-onset pneumonia: a propensity score-matching study
Jonghoo Lee, Jae-Uk Song
Korean J Intern Med. 2020;35(3):630-640. Published online February 24, 2020
Background/Aims: Although pneumococcal urinary antigen tests (PUATs) have universally been used for the diagnosis of pneumococcal pneumonia, data on the efficacy of these exams are limited. The objective of our study was to investigate the clinical impact of the PUAT in patients with community-onset..
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Hemato-oncology / Original Article
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Korean J Intern Med. 2020;35(2):429-437. Published online January 10, 2019
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
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Gastroenterology / Original Article
Comparison of procedural sequence in same-day bidirectional endoscopy: a systematic review and meta-analysis
Geun Joo Choi, Hyoung-Chul Oh, Hee-Kyeong Seong, Jeong Wook Kim, Jin Soo Ko, Hyun Kang
Korean J Intern Med. 2020;35(2):331-341. Published online December 27, 2019
Background/Aims: To compare the efficacy and safety of procedural sequence in same-day bidirectional endoscopy.
Methods: We searched OVID-MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar to identify randomized controlled trials that compared the procedural sequenc..
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Rheumatology / Original Article
Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset,
and HLA-B51
Hee Jung Ryu, Mi Ryoung Seo, Hyo Jin Choi, Han Joo Baek
Korean J Intern Med. 2018;33(5):1025-1031. Published online January 12, 2017
Background/Aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is t..
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Allergy / Review
Genetic markers of severe cutaneous adverse reactions
Jae-Woo Jung, Jae-Yeol Kim, In-Won Park, Byoung-Whui Choi, Hye-Ryun Kang
Korean J Intern Med. 2018;33(5):867-875. Published online June 22, 2018
Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they c..
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ETC / Review
Fundamental role of dendritic cells in inducing Th2 responses
Byoungjae Kim, Tae Hoon Kim
Korean J Intern Med. 2018;33(3):483-489. Published online March 5, 2018
A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, part..
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Nephrology / Original Article
Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody
in kidney transplant recipients with allograft dysfunction
Byung Ha Chung, Jeong Ho Kim, Bum Soon Choi, Cheol Whee Park, Ji-Il Kim, In Sung Moon, Yong-Soo Kim, Yeong Jin Choi, Eun-Jee Oh, Chul Woo Yang
Korean J Intern Med. 2018;33(1):157-167. Published online October 20, 2016
Background/Aims: This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction.
Methods: We analyzed the presence of HLA-DSA in 210 KTRs ..
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Gastroenterology / Original Article
Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1
Woon Geon Shin, Bum Joon Park, Sung Joong Lee, Jae Gyu Kim
Korean J Intern Med. 2018;33(1):81-90. Published online January 16, 2017
Background/Aims: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria up-regulates intercellular adhesion molecule-1 (ICAM-1)..
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Gastroenterology / Original Article
Long-term real-world entecavir therapy in treatment-naïve hepatitis B patients: base-line
hepatitis B virus DNA and hepatitis B surface antigen levels predict virologic response
Ju-Yeon Cho, Won Sohn, Dong-Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2017;32(4):636-646. Published online November 4, 2016
Background/Aims: Entecavir is a potent nucleoside analogue with high efficacy and barrier for resistance. We aimed to investigate the long-term efficacy and viral resistance rate of entecavir and explore the factors associated with virologic response, including quantitative hepatitis B surface anti..
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Pulmonology / Review
The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
Chang Dong Yeo, Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chan Kwon Park, Jin Woo Kim, Young Kyoon Kim, Seung Joon Kim
Korean J Intern Med. 2017;32(4):589-599. Published online June 30, 2017
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can occur under oxygen tensions of < 40 mmHg through hypoxia-inducible..
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Allergy / Original Article
Clinical features of elderly chronic urticaria
Ga-Young Ban, Mi-Yea Kim, Hye-Soo Yoo, Dong-Ho Nahm, Young-Min Ye, Yoo-Seob Shin, Hae-Sim Park
Korean J Intern Med. 2014;29(6):800-806. Published online October 31, 2014
Background/Aims: Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this disease in the elderly population.
Methods: We investigated the prevalence and clinical features of CU in..
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